Enhanced Photocatalytic Decomposition Efficacy of Novel MgO NPs: Impact of Annealing Temperatures

Diana, P.; Saravanakumar, S.; Prasad, K. Hari; Sivaganesh, D.; Chidhambaram, N.; Isaac, R. S. Rimal; Alshahrani, Thamraa; Shkir, Mohd.; AIFaify, S.; Ali, K.S. Syed

doi:10.1007/s10904-021-01896-4

Cited by 20 publications

(6 citation statements)

References 35 publications

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“…Firstly, MgO nanoparticles (MgO-NPs) were prepared by the method reported by Diana et al [ 19 ]. Briefly, urea was added to an aqueous solution of magnesium nitrate (0.25 M) under constant stirring at 70 °C until gel formation.…”

Section: Methodsmentioning

confidence: 99%

Dual Hyaluronic Acid and Folic Acid Targeting pH-Sensitive Multifunctional 2DG@DCA@MgO-Nano-Core–Shell-Radiosensitizer for Breast Cancer Therapy

Askar

Thabet

El-Sayyad

et al. 2021

Cancers

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Globally, breast cancer (BC) poses a serious public health risk. The disease exhibits a complex heterogeneous etiology and is associated with a glycolytic and oxidative phosphorylation (OXPHOS) metabolic reprogramming phenotype, which fuels proliferation and progression. Due to the late manifestation of symptoms, rigorous treatment regimens are required following diagnosis. Existing treatments are limited by a lack of specificity, systemic toxicity, temporary remission, and radio-resistance in BC. In this study, we have developed CD44 and folate receptor-targeting multi-functional dual drug-loaded nanoparticles. This composed of hyaluronic acid (HA) and folic acid (FA) conjugated to a 2-deoxy glucose (2DG) shell linked to a layer of dichloroacetate (DCA) and a magnesium oxide (MgO) core (2DG@DCA@MgO; DDM) to enhance the localized chemo-radiotherapy for effective BC treatment. The physicochemical properties of nanoparticles including stability, selectivity, responsive release to pH, cellular uptake, and anticancer efficacy were thoroughly examined. Mechanistically, we identified multiple component signaling pathways as important regulators of BC metabolism and mediators for the inhibitory effects elicited by DDM. Nanoparticles exhibited sustained DDM release properties in a bio-relevant media, which was responsive to the acidic pH enabling eligibility to the control of drug release from nanoparticles. DDM-loaded and HA–FA-functionalized nanoparticles exhibited increased selectivity and uptake by BC cells. Cell-based assays revealed that the functionalized DDM significantly suppressed cancer cell growth and improved radiotherapy (RT) through inducing cell cycle arrest, enhancing apoptosis, and modulating glycolytic and OXPHOS pathways. By highlighting DDM mechanisms as an antitumor and radio-sensitizing reagent, our data suggest that glycolytic and OXPHOS pathway modulation occurs via the PI3K/AKT/mTOR/NF-κB/VEGFlow and P53high signaling pathway. In conclusion, the multi-functionalized DDM opposed tumor-associated metabolic reprogramming via multiple signaling pathways in BC cells as a promising targeted metabolic approach.

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Section: Methodsmentioning

confidence: 99%

Dual Hyaluronic Acid and Folic Acid Targeting pH-Sensitive Multifunctional 2DG@DCA@MgO-Nano-Core–Shell-Radiosensitizer for Breast Cancer Therapy

Askar

Thabet

El-Sayyad

et al. 2021

Cancers

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“…The photocatalytic degradation efficiency ( η ) of the synthesized photocatalysts was evaluated using the following relation [ 35 ]

\begin{equation}\eta = \left( {1 - \frac{C}{{{C_{\rm{o}}}}}} \right)100{\rm{\;\% \;}}\end{equation}

where C is the dye concentration at any irradiation time and C 0 is the initial dye concentration. The photocatalytic degradation efficiencies evaluated for the photocatalysts are depicted in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…The photocatalytic degradation efficiency (𝜂) of the synthesized photocatalysts was evaluated using the following relation [35] 𝜂 =…”

Section: Photocatalytic Activitymentioning

confidence: 99%

Leveraging the Photocatalytic Degradation Efficiency of Solution Combustion Derived ZnO Photocatalyst through Palladium Doping

Irine¹,

Rathika²,

Gobalakrishnan

et al. 2022

Crystal Research and Technology

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In this work, palladium-doped zinc oxide nanoparticle photocatalysts with various amounts of palladium are prepared through a solution combustion method. Their crystal structure, optical, morphological, and thermal properties are examined by X-ray diffractometry (XRD), UV-vis Diffuse Reflectance Spectroscopy (DRS), scanning electron microscopy (SEM), and thermogravimetric analysis, respectively. The XRD results demonstrate that palladium doping does not induce any secondary phases related to metallic palladium or palladium oxides. The inclusion of palladium with ZnO decreases the bandgap value and the lowest bandgap value of 3.19 eV is evaluated for the 3% palladium-doped ZnO photocatalyst. The Fourier Transform Infra-Red (FTIR) spectroscopic analysis reveals the characteristic stretching vibrations of ZnO at 460 cm −1 in all the synthesized photocatalysts. Palladium doping induces thermal stability enhancement in the synthesized photocatalysts. The optimal palladium doping enhances the photocatalytic degradation efficiency significantly against methylene blue (MB) dye. A plausible mechanism is also discussed for photocatalytic degradation enhancement due to palladium doping.

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“…Synthesis of DDM 1. Preparation of MgO nanoparticles Firstly, MgO nanoparticles (MgO-NPs) were prepared by the method reported by Diana et al [17]. Brie y, urea was added to an aqueous solution of magnesium nitrate (0.25 M) under constant stirring at 70°C until gel formation.…”

Section: Materials and Reagentsmentioning

confidence: 99%

Dual Hyaluronic Acid and Folic Acid Targeting pH-Sensitive Multifunctional 2DG@DCA@MgO-Nano-Core-Shell-Radiosensitizer for Breast Cancer Therapy

Askar

Thabet

El-Sayyad

et al. 2021

Preprint

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Background: Globally, breast cancer (BC) poses a serious public health risk. The disease exhibits a complex heterogeneous etiology and is associated with glycolysis and oxidative phosphorylation (OXPHOS) metabolic reprograming pathways which fuel proliferation and progression. Due to the late manifestation of symptoms, rigorous treatment regimens are required following diagnosis. Existing treatments are limited by a lack of specificity, systemic toxicity, temporary remission, and radio-resistance in BC. In this study, we developed CD44 and folate receptor-targeting multi-functional dual drug-loaded nanoparticles (DDM). These contained a hyaluronic acid (HA) and folic acid (FA) conjugated to a dichloroacetate (DCA) shell linked to a 2-deoxy glucose (2DG) and magnesium oxide (MgO) core to enhance localized chemo-radiotherapy for effective BC treatment.Methods: The physicochemical properties of nanoparticles, including stability, selectivity, release in response to pH, cellular uptake, and anticancer efficacy were comprehensively examined. Mechanistically, we identified multiple component signal pathways as important regulators of BC metabolism and mediators of inhibitory effects toward DDM.Results: Nanoparticles exhibited sustained DDM release properties in bio-relevant media, which was responsive to acidic pH providing ﬂexibility to the control of drug release from nanoparticles. DDM-loaded and HA-FA-functionalized nanoparticles exhibited increased selectivity and uptake by BC cells. Cells study indicated that functionalized DDM significantly suppressed cancer cell growth and radiotherapy (RT) improvement via cell cycle arrest, apoptosis enhancement, and modulation of glycolysis and OXPHOS pathways.Conclusions: By highlighting DDM mechanisms as an antitumor and radio-sensitizing reagent, our analysis also revealed glycolysis and OXPHOS modulation via PI3K/AKT/mTOR/NF-κB/VEGFlow and P53high signal pathways. In conclusion, we indicated that multi-functionalized DDM depletion-mediated metabolic reprogramming via multiple signal pathways in BC cells is a promising targeted metabolic therapy.

show abstract

Enhanced Photocatalytic Decomposition Efficacy of Novel MgO NPs: Impact of Annealing Temperatures

Cited by 20 publications

References 35 publications

Dual Hyaluronic Acid and Folic Acid Targeting pH-Sensitive Multifunctional 2DG@DCA@MgO-Nano-Core–Shell-Radiosensitizer for Breast Cancer Therapy

Dual Hyaluronic Acid and Folic Acid Targeting pH-Sensitive Multifunctional 2DG@DCA@MgO-Nano-Core–Shell-Radiosensitizer for Breast Cancer Therapy

Leveraging the Photocatalytic Degradation Efficiency of Solution Combustion Derived ZnO Photocatalyst through Palladium Doping

Dual Hyaluronic Acid and Folic Acid Targeting pH-Sensitive Multifunctional 2DG@DCA@MgO-Nano-Core-Shell-Radiosensitizer for Breast Cancer Therapy

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