Based on the study of the duct leak detection system of commercial aircraft in existence, the insulation structure of high temperature pneumatic duct system of the aircraft is improved with multilayer insulation method and its engineering calculation method is derived. Also, the insulation experiment platform of the high temperature pneumatic duct system is built to verify the applicability and feasibility of the engineering calculation method. The research result shows that the results from the engineering calculation method is not fit the experimental data perfectly, the margin of error is 17 percentage. The main reason is that the diversion tunnels has a little effect on the temperature distribution and in these cases parameter modification method should be adopted in the engineering calculation method. These works would be helpful for the design and optimization of the high temperature pneumatic duct system.