“…For example, insulin stimulates DNA synthesis in bovine corneal [Feldman et al, 1993;Crow et al, 1994] and retinal [King et al, 1983] endothelium, but has no signi®cant stimulatory effect on endothelium derived from guinea pig coronary [Schonwald et al, 1991], human umbilical vein [Taggart and Stout, 1980;King et al, 1983] and bovine aortic [King et al, 1983] endothelial cells. King et al used Scatchard analysis to demonstrate capacity of 125 I-insulin to bind high-af®nity receptors on bovine retinal capillary endothelial and aortic endothelial cells [King et al, 1983], and suggested differences in the responsiveness of endothelial cells derived from capillaries and large vessels to insulin.…”