“…In order to simplify preparation procedures, achieve high sensitivity, and avoid the high cost and photo-bleaching of fluorescent tags, optical fiber RI-based biosensors have been studied extensively [15,16] as the optical fiber platform offers a number of advantages, namely small size, bio-compatibility, immunity to electromagnetic interference, and the potential for remote operation. There are numerous optical fiber sensing mechanisms that have been demonstrated for use as RI sensors, with examples including Mach-Zehnder (MZ) interferometers [12,[17][18][19][20][21], Fabry-Perot interferometers [22,23], surface plasmon resonance [24,25], fiber Bragg-gratings [26][27][28], longperiod fiber gratings [29][30][31], and Sagnac (SG) interferometers [13,32]. There are typically trade-offs in performance depending on the mechanism used.…”