High performance mid‐infrared photodetectors play an irreplaceable role in optical communication, security monitoring, biological, and medical imaging and so on. Two‐dimensional (2D) materials have demonstrated great potential for infrared photodetection application. In recent years, the research on 2D materials based mid‐infrared photodetectors has underwent a fast growth. In this review, we summarize recent advances in the 2D materials based photodetectors, with an emphasis on mid‐infrared photodetection. In the first section, we start with a brief discussion on the potential advantages of 2D materials for mid‐infrared photodetection. Next, we focus on the development of 2D mid‐infrared photodetectors, and then discuss the challenges of this rapidly‐growing field. Following this, we review the solutions for improving the device performances and point out the issues remained to be solved. Finally, the future directions in this area are discussed and general advices are provided for the future development of high‐performance mid‐infrared photodetectors based on 2D materials.