Enhanced sensitivity to quipazine in the genetically dystonic rat (dt)

Michela, Victoria L.; Stratton, Sara E.; Lorden, Joan F.

doi:10.1016/0091-3057(90)90053-k

Cited by 12 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…suggesting that activation of olivary neurons as demonstrated in the present study would be able to modulate motor output. A similar tremorogenic 5-HT modulation of inferior olive activity 53 effect of systemic quipazine injection has also been reported in young rats (Michela et al, 1990). Furthermore, an impairment of the 5-HT system in the cerebellum as well as in the inferior olive has been hypothesized in patients with cerebellar ataxia, given that the administration of 5-hydroxytryptophan, a precursor of 5-HT, can induce a significant regression of the symptoms (Trouillas, 1993).…”

Section: Functional Significance Of 5-ht In the Inferior Olivementioning

confidence: 57%

Serotonin Modulation of Inferior Olivary Oscillations and Synchronicity: A Multiple‐electrode Study in the Rat Cerebellum

Sugihara

Lang

Llinás

1995

Eur J of Neuroscience

138

View full text Add to dashboard Cite

Simultaneous recording of complex spikes from multiple Purkinje cells (up to 44) in the rat cerebellum was used to examine the effects of 5-hydroxytryptamine (serotonin, 5-HT) on olivocerebellar function. Microinjection into the inferior olive was found to increase the average firing rate of inferior olivary neurons while slowing their oscillation frequency and increasing the coherence of their oscillations. Indeed, while the normal rostrocaudal band of synchronous activity remained unchanged, the degree of synchrony between Purkinje cell complex spikes within this band was enhanced following the 5-HT injections. Multiple-electrode recordings obtained from crus Ila and vermal lobule Vlb yielded qualitatively similar results; however, the effects on vermal activity were more pronounced. The effects of the 5-HT microinjection decayed with a time course of 75 min. The half-maximum effective concentration of 5-HT was between 10 and 100 microM. Injections of various 5-HT agonists and antagonists demonstrated that a 5-HT type-2A (5-HT2A) receptor is the main mediator for the 5-HT effect, which was very similar to the effect produced by injections of harmaline. However, 5-HT and harmaline appear to have independent mechanisms since the action of harmaline was not blocked by the 5-HT2A antagonist LY53857. A possible role for 5-HT, as a physiological enhancer of the timing of motor function of the olivocerebellar system, is discussed.

show abstract

Section: Functional Significance Of 5-ht In the Inferior Olivementioning

confidence: 57%

Serotonin Modulation of Inferior Olivary Oscillations and Synchronicity: A Multiple‐electrode Study in the Rat Cerebellum

Sugihara

Lang

Llinás

1995

Eur J of Neuroscience

138

View full text Add to dashboard Cite

show abstract

“…60 In contrast, dt rats are hypersensitive to tremorogenic effects induced by the serotonergic agonist quipazine, which also stimulates IO activity. 68 Serotonergic regulation appears normal elsewhere in dt rat brain, 62,63 suggesting defects specific to the olivocerebellar pathway are associated with the dystonia.…”

mentioning

confidence: 99%

Animal models of generalized dystonia

2005

View full text Add to dashboard Cite

Summary: Dystonia is a prevalent neurological disorder characterized by abnormal co-contractions of antagonistic muscle groups that produce twisting movements and abnormal postures. The disorder may be inherited, arise sporadically, or result from brain insult. Dystonia is a heterogeneous disorder because patients may exhibit focal or generalized symptoms associated with abnormalities in many brain regions including basal ganglia and cerebellum. Elucidating the pathogenic mechanisms underlying dystonia has therefore been challenging. Animal models of dystonia exhibit similar heterogeneity and are useful for understanding pathogenesis. The neurochemical and neurophysiological abnormalities in rodents with idiopathic generalized dystonia suggest that dysfunctional output from basal ganglia, cerebellum, or from multiple systems is the cause of motor dysfunction. Findings from drug-or toxininduced dystonia in rodents and nonhuman primates mirror the genetic models. The parallels between dystonia in humans and animals suggest that the models will continue to prove useful in determining pathogenesis. Furthermore, detailed characterization of the existing models of dystonia and the development of new models hold promise for the identification of novel therapeutics.

show abstract

The novel selective and silent 5-HT1A receptor antagonist (+)-WAY-100135 aggravates dystonic movements in a mutant hamster model

Löscher

Richter²

1994

European Journal of Pharmacology

View full text Add to dashboard Cite

Enhanced sensitivity to quipazine in the genetically dystonic rat (dt)

Cited by 12 publications

References 41 publications

Serotonin Modulation of Inferior Olivary Oscillations and Synchronicity: A Multiple‐electrode Study in the Rat Cerebellum

Serotonin Modulation of Inferior Olivary Oscillations and Synchronicity: A Multiple‐electrode Study in the Rat Cerebellum

Animal models of generalized dystonia

The novel selective and silent 5-HT1A receptor antagonist (+)-WAY-100135 aggravates dystonic movements in a mutant hamster model

Contact Info

Product

Resources

About