Enhanced Sporicidal Activity of Alcohol and Epigallocatechin-Palmitate-Based Hand Hygiene Formulations Comprised of Plant-Derived Compounds

Chu, Tin-Chun; Lee, Lee H.; Yussof, Ayuni; Lopez, Sabrina; Herrera, Gabriela; Luna, Priscilla; Uddin, Mahfuza; Wu, Laying; Murzaku, John A.; Dickinson, Douglas; Hsu, Stephen

doi:10.4236/jbm.2020.86009

Cited by 3 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alcohol and EGCG-palmitate-based surface disinfectant formulations produce high sporicidal effects on a broad spectrum of bacterial spores. The swift inactivation of spores is likely attributed to EGCG-palmitate damaging the spore shell's structure, facilitating alcohol penetration of the spore matrix, and resulting in the prompt and irreversible inactivation of intrinsic biomolecules [76,77]. It has also been reported that EGCG stearate exhibits an enhanced binding affinity to the phospholipid bilayer, thereby inhibiting biofilm formation by Streptococcus mutans and exerting antibacterial effects [71].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Comprehensive Review of EGCG Modification: Esterification Methods and Their Impacts on Biological Activities

Zhuang,

Quan,

Wang

et al. 2024

Foods

View full text Add to dashboard Cite

Epigallocatechin gallate (EGCG), the key constituent of tea polyphenols, presents challenges in terms of its lipid solubility, stability, and bioavailability because of its polyhydroxy structure. Consequently, structural modifications are imperative to enhance its efficacy. This paper comprehensively reviews the esterification techniques applied to EGCG over the past two decades and their impacts on bioactivities. Both chemical and enzymatic esterification methods involve catalysts, solvents, and hydrophobic groups as critical factors. Although the chemical method is cost-efficient, it poses challenges in purification; on the other hand, the enzymatic approach offers improved selectivity and simplified purification processes. The biological functions of EGCG are inevitably influenced by the structural changes incurred through esterification. The antioxidant capacity of EGCG derivatives can be compromised under certain conditions by reducing hydroxyl groups, while enhancing lipid solubility and stability can strengthen their antiviral, antibacterial, and anticancer properties. Additionally, esterification broadens the utility of EGCG in food applications. This review provides critical insights into developing cost-effective and environmentally sustainable selective esterification methods, as well as emphasizes the elucidation of the bioactive mechanisms of EGCG derivatives to facilitate their widespread adoption in food processing, healthcare products, and pharmaceuticals.

show abstract

Section: Antibacterial Activitymentioning

confidence: 99%

Comprehensive Review of EGCG Modification: Esterification Methods and Their Impacts on Biological Activities

Zhuang,

Quan,

Wang

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

“…Modified lipophilic polyphenols (LTPs) were shown to act synergistically with antibiotics to inhibit the growth of various Gram-positive and Gram-negative bacteria [19]. Another lipophilic EGCG derivative, EGCG-palmitate-based formulations exhibited sporicidal activity [28,29]. Recently, a derivative of EGCG known as epigallocatechin-3-gallate-stearate (EGCG-S) was synthesized by esterification of fatty acid making EGCG lipophilic and thereby, enhancing its absorption in the lipid bilayer.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Biofilm Formation by the Synergistic Action of EGCG-S and Antibiotics

2021

Self Cite

View full text Add to dashboard Cite

Biofilm, a stress-induced physiological state, is an established means of antimicrobial tolerance. A perpetual increase in multidrug resistant (MDR) infections associated with high mortality and morbidity have been observed in healthcare settings. Multiple studies have indicated that the use of natural products can prevent bacterial growth. Recent studies in the field have identified that epigallocatechin gallate (EGCG), a green tea polyphenol, could disrupt bacterial biofilms. A modified lipid-soluble EGCG, epigallocatechin-3-gallate-stearate (EGCG-S), has enhanced the beneficial properties of green tea. This study focuses on utilizing EGCG-S as a novel synergistic agent with antibiotics to prevent or control biofilm. Different formulations of EGCG-S and selected antibiotics were used to study their combinatorial effects on biofilms produced by five potential pathogenic bacteria, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcusepidermidis, and Mycobacterium smegmatis. The crystal violet (CV) assay and the sensitive fluorescence-based resazurin biofilm viability assay were used to assess the biofilm production. Our results identified optimal formulation for each bacterium, effectively inhibiting biofilm formation to an extent of 95–99%. Colony-forming unit (CFU) and cell viability analyses showed a decrease of viable bacteria. These results depict the potential of EGCG-S as a synergistic agent with antibiotics and as an anti-biofilm agent.

show abstract

Virucidal activities of novel hand hygiene and surface disinfectant formulations containing EGCG-palmitates (EC16)

Dickinson¹,

Marsh

Shao³

et al. 2022

American Journal of Infection Control

View full text Add to dashboard Cite

Enhanced Sporicidal Activity of Alcohol and Epigallocatechin-Palmitate-Based Hand Hygiene Formulations Comprised of Plant-Derived Compounds

Cited by 3 publications

References 10 publications

Comprehensive Review of EGCG Modification: Esterification Methods and Their Impacts on Biological Activities

Comprehensive Review of EGCG Modification: Esterification Methods and Their Impacts on Biological Activities

Inhibition of Biofilm Formation by the Synergistic Action of EGCG-S and Antibiotics

Virucidal activities of novel hand hygiene and surface disinfectant formulations containing EGCG-palmitates (EC16)

Contact Info

Product

Resources

About