Enhanced stability and dermal delivery of hydroquinone using solid lipid nanoparticles

Ghanbarzadeh, Saeed; Hariri, Reza; Kouhsoltani, Maryam; Shokri, Javad; Javadzadeh, Yousef; Hamishehkar, Hamed

doi:10.1016/j.colsurfb.2015.10.041

Cited by 88 publications

(47 citation statements)

References 45 publications

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“…We directly went through the optimised way of SLN production established for encapsulation of hydrophilic drugs in our laboratory. The way of fabrication process optimisation has been reported in our previous studies Pezeshki et al, 2014;Ghanbarzadeh et al, 2015): at first, 20 mg of Dox was dissolved in 400 ll hot aqueous phase (80 C) containing 3% poloxamer as emulsifier. Then drug aqueous phase was added dropwise into the molten lipid phase (2 g Precirol) then the excess heated aqueous phase was added by syringe (5 ml) to the melt lipid and homogenised at 20 000 rpm (Silent Crusher M, Heidolph, Germany), for 30 min to prepare nanoemulsion.…”

Section: Preparation Of Sln Formulationmentioning

confidence: 99%

Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer

Tupal

Sabzichi

Ramezani

et al. 2016

Journal of Microencapsulation

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Section: Preparation Of Sln Formulationmentioning

confidence: 99%

Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer

Tupal

Sabzichi

Ramezani

et al. 2016

Journal of Microencapsulation

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“…28,29 Briefly, soy lecithin and dexamethasone were dissolved in soybean oil under low heat, followed by organic solvent dissolution and film dispersion. Glycerol and Pluronic F68 were dissolved in deionized water as the aqueous phase.…”

Section: Preparation Of L/npsmentioning

confidence: 99%

Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone

Ban¹,

Zhang²,

Huang³

et al. 2017

IJN

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Drug delivery carriers can maintain effective therapeutic concentrations in the eye. To this end, we developed lipid nanoparticles (L/NPs) in which the surface was modified with positively charged chitosan, which engaged in hydrogen bonding with the phospholipid membrane. We evaluated in vitro corneal permeability and release characteristics, ocular irritation, and drug dynamics of modified and unmodified L/NPs in aqueous humor. The size of L/NPs was uniform and showed a narrow distribution. Corneal permeation was altered by the presence of chitosan and was dependent on particle size; the apparent permeability coefficient of dexamethasone increased by 2.7 and 1.8 times for chitosan-modified and unmodified L/NPs, respectively. In conclusion, a chitosan-modified system could be a promising method for increasing the ocular bioavailability of unmodified L/NPs by enhancing their retention time and permeation into the cornea. These findings provide a theoretical basis for the development of effective drug delivery systems in the treatment of ocular disease.

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“…Although both have the preparation methods, NLC may disrupt the crystal structure of regular solid lipid. When liquid lipid is added, it may cause irregular particle structure, increase the ratio of crystalline, and thus increase the encapsulation efficiency and drug loading [8,9]. The NLC system not only increases the stability of the compound, but also has good skin adhesion and bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method

Lin

Kuo

et al. 2017

Journal of Nanomaterials

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Nanostructured lipid carrier (NLC) was prepared by homogenization emulsification method and improved with modified surfactants. The properties of nanoparticles were investigated using the NLC system for hydroquinone (HQ) as a model drug and by increasing the light stability of hydroquinone. The optimized condition of NLC in stirring was 1200 rpm, the homogenized speed was 8000 rpm, solid oil to liquid oil ratio was 3 : 7, and lecithin to surfactant ratio was 3 : 1. The particle size was 393.30 ± 28.23 nm and the encapsulation efficiency was 22.13 ± 2.66%. The zeta-potential of HQ-NLC was better than −30 mV. In the thermogravimetric analysis (TGA) studies, adding of PLANTACARE 2000 UP for HQ-NLC has better heat resisting property than the HQ-NLC only. The addition of PLANTACARE 2000 UP to NLC shows better permeability (125.10%) than that of Blank. In the stability studies, the HQ-NLC after UVA/UVB irradiation has better inhibition rate (34.25%) than that of the Blank. In the present study, NLC system has successfully improved the light stability and the skin permeability of active compound. Therefore, the NLC might be a potential delivery vehicle for transdermal products in the future.

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Enhanced stability and dermal delivery of hydroquinone using solid lipid nanoparticles

Cited by 88 publications

References 45 publications

Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer

Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer

Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone

Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method

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