Enhanced stress-induced senescence-response may increase species lifespan

Lorenzini, Antonello; Sell, Christian

doi:10.18632/aging.203216

Cited by 2 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We believe that our observation adds to the understanding of the complex phenomenon of cancer and that, in the future, the potential of comparative analysis must be further exploited through additional observations, especially those using cancer-resistant animal models. Comparative biology has the potential to show important biological relationships, such as the inverse link between developmental rate and longevity [ [40] , [41] , [42] ] that are undetected in studies of individual animal models.…”

Section: Discussionmentioning

confidence: 99%

The spontaneous immortalization probability of mammalian cell culture strains, as their proliferative capacity, correlates with species body mass, not longevity

et al. 2023

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

The spontaneous immortalization probability of mammalian cell culture strains, as their proliferative capacity, correlates with species body mass, not longevity

et al. 2023

Self Cite

View full text Add to dashboard Cite

Cellular senescence in Alzheimer’s disease: from physiology to pathology

Zhu,

Wu,

Yang

2024

Transl Neurodegener

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, characterized by the accumulation of Aβ and abnormal tau hyperphosphorylation. Despite substantial efforts in development of drugs targeting Aβ and tau pathologies, effective therapeutic strategies for AD remain elusive. Recent attention has been paid to the significant role of cellular senescence in AD progression. Mounting evidence suggests that interventions targeting cellular senescence hold promise in improving cognitive function and ameliorating hallmark pathologies in AD. This narrative review provides a comprehensive summary and discussion of the physiological roles, characteristics, biomarkers, and commonly employed in vivo and in vitro models of cellular senescence, with a particular focus on various cell types in the brain, including astrocytes, microglia, oligodendrocyte precursor cells, neurons, and endothelial cells. The review further delves into factors influencing cellular senescence in AD and emphasizes the significance of targeting cellular senescence as a promising approach for AD treatment, which includes the utilization of senolytics and senomorphics.

show abstract

Enhanced stress-induced senescence-response may increase species lifespan

Cited by 2 publications

References 8 publications

The spontaneous immortalization probability of mammalian cell culture strains, as their proliferative capacity, correlates with species body mass, not longevity

The spontaneous immortalization probability of mammalian cell culture strains, as their proliferative capacity, correlates with species body mass, not longevity

Cellular senescence in Alzheimer’s disease: from physiology to pathology

Contact Info

Product

Resources

About