The spontaneous immortalization probability of mammalian cell culture strains, as their proliferative capacity, correlates with species body mass, not longevity

Aging like fine wine: Mischievous microbes and other factors influencing senescence

“…In a recent study, Perillo et al. shed light on the negative relationship between cellular immortalization, the ability of cells to evade senescence and proliferate indefinitely, and species body mass [ 16 ]. Expanding on this, their latest review delves deeper into Peto's paradox, exploring the evolutionary adaptations that enable species to evolve longevity despite large body mass, while also addressing strategies to mitigate cancer risk in long-lived organisms [ 17 ].…”

“How sad it is! I shall grow old, and horrible, and dreadful” – The ups and downs of cell senescence

“…found a negative link between immortalization probability and species body mass. The researchers hence suggest that a stringent molecular mechanism must exist that controls genetic stability during evolution of large body mass [ 18 ].…”