Enhanced Structure-Function Relationship in Glaucoma With an Anatomically and Geometrically Accurate Neuroretinal Rim Measurement

Danthurebandara, Vishva M.; Sharpe, Glen P.; Hutchison, Donna M.; Denniss, Jonathan; Nicolela, Marcelo T.; McKendrick, Allison M; Turpin, Andrew; Chauhan, Balwantray C.

doi:10.1167/iovs.14-15375

Cited by 90 publications

(57 citation statements)

References 30 publications

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“…In the current study, applying a correction for the papillomacular tilt significantly changed cpRNFL thickness measurements, in agreement with a previous report. 31 Interestingly, Danthurebandara et al 32 have recently reported that applying a correction for papillomacular tilt did not result in any measurable improvement in the structure-function relationship, which is contradictory to our results. The reason for these conflicting results is not clear but may be attributed to the different measurement site, since the Relative probability is defined as the possibility this model minimizes the information loss, compared with the model with smallest AICc.…”

Section: Discussioncontrasting

confidence: 99%

Adjusting Circumpapillary Retinal Nerve Fiber Layer Profile Using Retinal Artery Position Improves the Structure–Function Relationship in Glaucoma

Fujino

Yamashita

Murata

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Fujino Y, Yamashita T, Murata H, Asaoka R. Adjusting circumpapillary retinal nerve fiber layer profile using retinal artery position improves the structure-function relationship in glaucoma. Invest Ophthalmol Vis Sci. 2016;57:3152-3158. DOI:10.1167/ iovs.16-19461 PURPOSE. To investigate whether correcting the circumpapillary retinal nerve fiber layer (cpRNFL) thickness profile, using retinal artery position and papillomacular bundle tilt, can improve the structure-function relationship in glaucoma patients.METHODS. Spectral-domain optical coherence tomography (SD-OCT) and visual field measurements were conducted in 142 eyes of 90 subjects with open angle glaucoma. The SD-OCT cpRNFL thickness profile was corrected for retinal artery position and/or papillomacular tilt in all twelve 308 sectors of the optic disc, and the structure-function relationship against corresponding 308 sectorial retinal sensitivity was investigated by using linear mixed model. RESULTS.Applying a correction to the cpRNFL thickness profile for retinal artery position resulted in a stronger structure-function relationship in all 12 sectors of the optic disc. Furthermore, applying a further adjustment for papillomacular tilt resulted in a further improvement in 9 of 12 sectors.CONCLUSIONS. Correcting cpRNFL profile, using the retinal artery position significantly strengthened the structure-function relationship. In most optic disc sectors, using the papillomacular bundle tilt improved cpRNFL thickness measurements.

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Section: Discussioncontrasting

confidence: 99%

Adjusting Circumpapillary Retinal Nerve Fiber Layer Profile Using Retinal Artery Position Improves the Structure–Function Relationship in Glaucoma

Fujino

Yamashita

Murata

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…In contrast to the results of Danethurebandara et al on optic discs of all sizes, sensitivity of BMO-MRW and RNFLT is not significantly different (p=0.09) 34. Malik et al 30 showed the same similar performance in glaucoma discrimination for 130 individuals with myopic discs.…”

Section: Discussionmentioning

confidence: 66%

The use of Bruch's membrane opening-based optical coherence tomography of the optic nerve head for glaucoma detection in microdiscs

et al. 2016

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“…However, all these were global correlations. Previous studies 22,23,30 have already established regional correlations between RNFL loss, GCC loss, and VF deficits. This study looked at sectoral vascular changes with corresponding regional VF defects.…”

Section: Discussionmentioning

confidence: 98%

Discriminant Function of Optical Coherence Tomography Angiography to Determine Disease Severity in Glaucoma

Kumar

Anegondi

Chandapura

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Kumar RS, Anegondi N, Chandapura RS, et al. Discriminant function of optical coherence tomography angiography to determine disease severity in glaucoma. Invest Ophthalmol Vis Sci. 2016;57:6079-6088. DOI:10.1167/iovs.16-19984 PURPOSE. To determine the discriminant function of optical coherence tomography angiography (OCTA) by disease severity in glaucoma.METHODS. In this prospective, observational cross-sectional study, all subjects underwent visual fields, retinal nerve fiber layer (RNFL) measurements, and OCTA imaging. Local fractal analysis was applied to OCTA images (radial peripapillary capillaries [RPC] layer). Vessel density en face and inside the disc and spacing between large and small vessels were quantified. Stepwise logistic regression was performed and a glaucoma severity score (range, 0-1: 0, normal; 1, severe glaucoma) was developed by using global and regional (superotemporal [ST], inferotemporal [IT], temporal, superonasal [SN], inferonasal, and nasal) vascular parameters. Glaucoma severity score was compared with visual field and RNFL indices. RESULTS.One hundred ninety-nine eyes (112 subjects) with glaucoma (28 eyes preperimetric; 83 early, 43 moderate, and 45 severe glaucoma) and 74 normal (54 subjects) eyes were enrolled. Preperimetric and glaucomatous eyes had significantly altered (P < 0.001) global vascular parameters as compared to normal; regionally, ST, then SN and IT sectors (in that order) showed more change in glaucomatous eyes. Vascular parameters showed better discriminant ability (area under the curve [AUC], sensitivity, and specificity of 0.70, 69.2%, and 72.9%, respectively) than structural parameters between normal and preperimetric glaucomatous eyes. Vascular parameters had comparable AUC (P > 0.05) to visual fields for perimetric glaucoma. Glaucoma severity score identified preperimetric glaucoma and early glaucoma better than did visual fields.CONCLUSIONS. Vascular parameters could be a useful adjunct tool to evaluate/diagnose glaucoma. Longitudinal studies are needed to determine their use in early detection and prognostication.Keywords: optical coherence tomography, glaucoma, visual field, angiography G laucoma is the leading cause of irreversible blindness worldwide.1,2 It is characterized by progressive degeneration of the optic nerve and loss of retinal ganglion cells, with corresponding visual field (VF) defects on standard automated perimetry.1,2 While raised intraocular pressure (IOP) is currently the only known modifiable risk factor for glaucoma, there is evidence that vascular insufficiency in the optic nerve head (ONH) also plays an important role in the pathogenesis of glaucoma.3-5 Currently, a number of methods are available for measuring ONH perfusion.6-11 Fluorescein angiography is invasive. It provides only superficial ONH perfusion and not deep perfusion.6 Noninvasive methods such as laser Doppler flowmetry and laser speckle flowgraphy have demonstrated decreased ONH perfusion in glaucomatous eyes, but have moderate repeatability.8,10 Doppler O...

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Enhanced Structure-Function Relationship in Glaucoma With an Anatomically and Geometrically Accurate Neuroretinal Rim Measurement

Abstract: The structure-function relationship was enhanced with BMO-MRW compared with the other neuroretinal rim measurements, due mainly to its geometrically accurate properties.

Cited by 90 publications

References 30 publications

Adjusting Circumpapillary Retinal Nerve Fiber Layer Profile Using Retinal Artery Position Improves the Structure–Function Relationship in Glaucoma

Adjusting Circumpapillary Retinal Nerve Fiber Layer Profile Using Retinal Artery Position Improves the Structure–Function Relationship in Glaucoma

The use of Bruch's membrane opening-based optical coherence tomography of the optic nerve head for glaucoma detection in microdiscs

Discriminant Function of Optical Coherence Tomography Angiography to Determine Disease Severity in Glaucoma

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