Enhanced top-down sensorimotor processing in somatic anxiety

Bouziane, Ismail; Das, Moumita; Friston, Karl J.; Caballero-Gaudes, César; Ray, Dipanjan

doi:10.1038/s41398-022-02061-2

Cited by 13 publications

(13 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…• Increased top-down sensorimotor resting-state effective connectivity in sensorimotor cortices [193] • Increased sensorimotor connectivity associated with panic-related symptoms [187,188].…”

Section: Functionmentioning

confidence: 99%

The neurobiology of irritable bowel syndrome

Mayer¹,

Ryu

Bhatt

2023

Mol Psychiatry

View full text Add to dashboard Cite

Irritable bowel syndrome (IBS) is the most prevalent disorder of brain-gut interactions that affects between 5 and 10% of the general population worldwide. The current symptom criteria restrict the diagnosis to recurrent abdominal pain associated with altered bowel habits, but the majority of patients also report non-painful abdominal discomfort, associated psychiatric conditions (anxiety and depression), as well as other visceral and somatic pain-related symptoms. For decades, IBS was considered an intestinal motility disorder, and more recently a gut disorder. However, based on an extensive body of reported information about central, peripheral mechanisms and genetic factors involved in the pathophysiology of IBS symptoms, a comprehensive disease model of brain-gut-microbiome interactions has emerged, which can explain altered bowel habits, chronic abdominal pain, and psychiatric comorbidities. In this review, we will first describe novel insights into several key components of brain-gut microbiome interactions, starting with reported alterations in the gut connectome and enteric nervous system, and a list of distinct functional and structural brain signatures, and comparing them to the proposed brain alterations in anxiety disorders. We will then point out the emerging correlations between the brain networks with the genomic, gastrointestinal, immune, and gut microbiome-related parameters. We will incorporate this new information into a systems-based disease model of IBS. Finally, we will discuss the implications of such a model for the improved understanding of the disorder and the development of more effective treatment approaches in the future.

show abstract

Section: Functionmentioning

confidence: 99%

The neurobiology of irritable bowel syndrome

Mayer¹,

Ryu

Bhatt

2023

Mol Psychiatry

View full text Add to dashboard Cite

show abstract

“…These low self-reported scores resulted in a bimodal distribution for anger, fear, and sadness. Bouziane et al also noted this scoring anomaly in the HCP dataset (Bouziane et al, 2022). One possible explanation for this anomaly could be the approximations used in the calculation of these scores within the HCP data analysis pipeline.…”

Section: Self-reported Scoresmentioning

confidence: 88%

“…Friston, 2011) of basic emotions involving emotion induction mechanism (de Marco et al, 2006;Dima et al, 2011;Mazzola et al, 2020;Seok & Cheong, 2019;Sladky et al, 2015). Recently, a study was conducted to examine the effective connectivity associated with trait somatic anxiety which yielded that there was improved top-down effective connectivity at high fear-related somatic arousal (Bouziane et al, 2022). It is crucial to understand the underlying neural mechanism of basic negative emotionsanger, fear, and sadness -in healthy subjects as it may provide comparative results to comprehend mental health disorders, however, there is no such investigation present in the previous literature.…”

Section: Introductionmentioning

confidence: 99%

“…Functional connectivity association has been explored with the self-reported negative trait emotions [34]- [39]. Recently, a study was conducted to examine the effective connectivity associated with trait somatic anxiety which yielded that there was improved top-down effective connectivity at high fear-related somatic arousal [40]. Researchers have also predicted negative trait affects using functional connectivity [35], [41].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuroticism and emotion regulation: An effective connectivity analysis of large-scale resting-state brain networks

Sultana

Hasan

Razi

2023

Preprint

View full text Add to dashboard Cite

Emotions are the foundational elements of mental health. Basic negative emotions have an assertive significant role in personality building while their unrestrained form can lead to mental health disorders and physical illnesses. The self-reported measures of negative emotions are usually associated with persistent feelings and hence may reflect trait-like negative emotions. Examining the association of brain intrinsic effective connectivity with the self-reported basic negative emotions can provide the basis of trait-like personality. The current study focuses on investigating the association of resting-state brain effective connectivity with the self-reported scores of all three basic negative emotions - anger, fear, and sadness. The relationship of effective connectivity with low and high levels of negative emotions was determined. The dataset comprises preprocessed resting-state fMRI scans and NIH emotion battery for self-reported basic emotions scores, of 1079 young healthy adults from Human Connectome Project (HCP). Subject-specific effective connectivity was discovered using spectral dynamic causal modelling, and the group-level effective connectivity association with the three basic emotions were examined using parametric empirical Bayes. The results revealed that the limbic-cortical connectivity from right amygdala (rAMG) to posterior cingulate cortex (PCC) could be the potential biomarker for heightened self-report negative emotions and hence could reflect trait-like personality related to negative emotions. The high anger-affect and high sadness have the strongest negative association with the inhibitory connection of rAMG to PCC while high fear-affect have the strongest negative association with inhibitory left anterior insula to PCC connectivity along with the second strongest negative association with inhibitory rAMG to PCC connectivity. The results of these association analyses may be used for the comparative analysis of causal brain connectivity in mental health disorders and may also represent the trait-like personality related to negative emotions.

show abstract

“…It is likely that, similar to people with somatic anxiety (Bouziane et al, 2022), healthy individuals scoring high on the ‘Low Neurological Threshold’ exerted greater top-down inhibitory control over excitability of the exteroceptive sensory (in this case visual) cortical areas than less sensitive individuals. Stronger top-down inhibitory control over the highly excited visual cortex may lead to a proportionally higher increase of alpha-beta power after intensive stimulation and explains its link to subjective sensory sensitivity and avoidance.…”

Section: Discussionmentioning

confidence: 99%

Changes in high-frequency aperiodic 1/f slope and periodic activity reflect post-stimulus functional inhibition in the visual cortex

Manyukhina,

Prokofyev,

Obukhova

et al. 2023

Preprint

View full text Add to dashboard Cite

It has been shown that cessation of intensive sensory stimulation is associated with a transient increase in functional inhibition in the sensory cortical areas. However, the electrophysiological correlates of this post-stimulus inhibition in the human brain have not been properly investigated.To investigate post-stimulus inhibition, we recorded magnetoencephalogram (MEG) at rest and after cessation of visual stimulation of varying intensity (high-contrast gratings drifting at a slow, medium, or high rate) in 25 healthy women aged 18-40 years. We analyzed condition-and intensity-related changes in MEG parameters sensitive to functional inhibition: periodic alpha-beta power, peak alpha frequency (PAF), and 1/f aperiodic slope. We also investigated the association of these parameters with sensory sensitivity and avoidance assessed by a questionnaire. To evaluate the influence of hormonal status on the studied parameters, participants were examined twice, during the follicular and luteal phases of the menstrual cycle (MC).Regardless of MC phase, increasing intensity of the preceding visual stimulation resulted in increased posterior post-stimulus alpha-beta power, PAF, and a more negative/steeper aperiodic (1/f) slope of the power spectrum in the 35-45 Hz range. Compared to rest, the post-stimulus period was characterized by higher PAF, a steeper 35-45 Hz 1/f slope in posterior cortical areas, and a widespread increase in beta power. While condition-and intensity-dependent changes in alpha-beta power and 1/f slope were correlated, changes in PAF did not correlate with either of them. Greater intensity-dependent increase in visual alpha-beta power predicted higher subjective sensory sensitivity/avoidance, suggesting stronger regulatory top-down modulation of visual cortex in individuals with heightened sensitivity.Our results show that several MEG parameters concordantly indicate a post-stimulus enhancement of inhibition that is proportional to the intensity of the preceding visual stimulation. While post-stimulus changes in alpha-beta power and 1/f slope may share some common mechanisms, changes in PAF reflect a distinct aspect of inhibitory regulation. Our results inform potential inhibition-based biomarkers for clinical and translational research.

show abstract

Enhanced top-down sensorimotor processing in somatic anxiety

Cited by 13 publications

References 108 publications

The neurobiology of irritable bowel syndrome

The neurobiology of irritable bowel syndrome

Neuroticism and emotion regulation: An effective connectivity analysis of large-scale resting-state brain networks

Changes in high-frequency aperiodic 1/f slope and periodic activity reflect post-stimulus functional inhibition in the visual cortex

Contact Info

Product

Resources

About