Enhanced transdermal delivery of curcumin nanosuspensions: A mechanistic study based on co-localization of particle and drug signals

Shi, Tingting; Lv, Yongjiu; Huang, Weizi; Fang, Zhezheng; Qi, Jianping; Chen, Zhongjian; Zhao, Weili; Wu, Wei; Lü, Yi

doi:10.1016/j.ijpharm.2020.119737

Cited by 38 publications

(17 citation statements)

References 57 publications

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“…For the CUR-GEL group, most of the green fluorescence appeared in the SC layer instead of entering the viable epidermis, indicating that the CUR-NCs showed poor passive diffusion. These results are in agreement with the recent literature on the transdermal penetration of CUR-NCs [9][10][11]. Compared with the gel vehicle, the MNs facilitated the CUR-NCs delivery into the deeper skin layers.…”

Section: Dermal Penetration Of Cur-mnssupporting

confidence: 92%

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Particle Size Effect of Curcumin Nanocrystals on Transdermal and Transfollicular Penetration by Hyaluronic Acid-Dissolving Microneedle Delivery

Xiang

et al. 2022

Pharmaceuticals

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Microneedles are one promising penetration enhancement vehicle to overcome the stratum corneum skin barrier, which hampers the penetration of drug nanocrystals by transdermal delivery. In order to clarify the particle size effect of nanocrystals on transdermal delivery, 60 nm, 120 nm, and 480 nm curcumin nanocrystals were fabricated and incorporated into dissolving hyaluronic acid polysaccharide microneedles. The microneedles showed good mechanical strength with 1.4 N/needle, possessing the ability to insert into the skin. The passive permeation results showed that the smaller particle size of 60 nm curcumin nanocrystals diffused faster and deeper than the larger 120 nm and 480 nm curcumin nanocrystals with size-dependent diffusion behaviors. Thereafter, higher concentration gradients and overlap diffusional coronas also formed in the skin layers by the smaller-particle-size nanocrystals. Furthermore, the diffusion rate of the smaller particle size of curcumin nanocrystals to the hair follicle was also higher than that of the larger curcumin nanocrystals. In conclusion, the particle sizes of curcumin nanocrystals influenced the transdermal and transfollicular penetration in deeper skin layers

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Section: Dermal Penetration Of Cur-mnssupporting

confidence: 92%

“…Briefly, higher concentration gradients, good skin moisturizing properties, and appropriate excipients enhance the diffusion and distribution of NCs in the skin layers or hair follicles. However, it has been difficult for the integral NCs to penetrate the SC [11].…”

Section: Introductionmentioning

confidence: 99%

Particle Size Effect of Curcumin Nanocrystals on Transdermal and Transfollicular Penetration by Hyaluronic Acid-Dissolving Microneedle Delivery

Xiang

et al. 2022

Pharmaceuticals

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“…By using this property, it was demonstrated that the intact nanocarriers could not enter the skin. Instead, they could filtrate into the SC and accumulate in hair follicles to release drugs and improve skin permeability 85 .…”

Section: Nanocarrier-based Transdermal Drug Delivery Strategiesmentioning

confidence: 99%

“…Moreover, a profound understanding of skin-nano interaction will further advance the design of nanocarriers for transdermal applications. The nanocarriers integrated with imaging functions or special chemical labels can assist the study of their skin entry mechanism, skin retention time, targeting ability, and dermal fate, making it easier for researchers to evaluate therapeutic results and optimize the formations 16 , 49 , 85 , 189 . Especially, developing nanocarriers with special-designed responsive imaging signals will be beneficial for studying the dynamic processes of nanocarriers in the skin, such as drug release from nanocarriers.…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Qu¹,

Geng²,

Liu³

et al. 2022

Theranostics

103

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Skin diseases are the fourth leading cause of nonfatal and chronic skin diseases, acting as a global burden and affecting the world economy. Skin diseases severely impact the patients' quality of life and have influenced their physical and mental state. Treatment of these skin disorders with conventional methods shows a lack of therapeutic efficacy, long treatment duration, recurrence of the condition, and systemic side effects due to improper drug delivery. However, these pitfalls can be overcome with the applications of advanced nanocarrier- and microneedle (MN)-based transdermal drug delivery strategies that provide efficient site-specific drug delivery at the target site. These advanced transdermal drug delivery strategies can be more effective than other drug administration routes by avoiding first-pass metabolism, enhancing the drug concentration in local skin lesions, and reducing systemic toxicity. Compared with traditional transdermal delivery methods, nanocarrier- or MN-based drug delivery systems are painless, noninvasive, or minimum-invasive and require no expensive equipment. More importantly, they can introduce more advanced functions, including increased skin penetration efficiency, controlled drug release rates, enhanced targeting abilities, and theranostic functions. Here, the emergence of versatile advanced transdermal drug delivery systems for the transdermal delivery of various drugs is reviewed, focusing on the design principles, advantages, and considerations of nanocarrier- and MN-based transdermal drug delivery strategies and their applications in treating diverse skin diseases, including psoriasis, dermatitis, melanoma, and other skin diseases. Moreover, the prospects and challenges of advanced transdermal delivery strategies for treating dermatological disorders are summarized.

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“…Curcumin (Cur), a natural polyphenol extracted from the rhizome of turmeric with various pharmacological effects. The topical application of Cur to the skin has long been of great interest in anti-oxidation, anti-inflammatory and light protection ( Shi et al, 2020 ). However, chemical instability, low water solubility, and poor skin penetration are major obstacles to their application as topical therapeutics ( Granata et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin

et al. 2022

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The present study focused on the development of Cur-loaded SOHA nanogels (Cur-SHNGs) to enhance the topical administration of Cur. The physiochemical properties of Cur-SHNGs were characterized. Results showed that the morphology of the Cur-SHNGs was spherical, the average size was 171.37 nm with a zeta potential of −13.23 mV. Skin permeation experiments were carried out using the diffusion cell systems. It was found that the skin retention of Cur-SHNGs was significantly improved since it showed the best retention value (0.66 ± 0.17 μg/cm2). In addition, the hematoxylin and eosin staining showed that the Cur-SHNGs improved transdermal drug delivery by altering the skin microstructure. Fluorescence imaging indicated that Cur-SHNGs could effectively deliver the drug to the deeper layers of the skin. Additionally, Cur-SHNGs showed significant analgesic and anti-inflammatory activity with no skin irritation. Taken together, Cur-SHNGs could be effectively used for the topical delivery of therapeutic drugs.

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Enhanced transdermal delivery of curcumin nanosuspensions: A mechanistic study based on co-localization of particle and drug signals

Cited by 38 publications

References 57 publications

Particle Size Effect of Curcumin Nanocrystals on Transdermal and Transfollicular Penetration by Hyaluronic Acid-Dissolving Microneedle Delivery

Particle Size Effect of Curcumin Nanocrystals on Transdermal and Transfollicular Penetration by Hyaluronic Acid-Dissolving Microneedle Delivery

Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin

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