Enhanced treatment for cerebral ischemia-reperfusion injury of puerarin loading liposomes through neutrophils-mediated targeted delivery

Liu, Wei; Lu, Haowei; Rao, Xiao-Yong; Li, Xiang; Lu, Hongdan; Li, Feifei; He, Yan; Yu, Riyue; Zhong, Rongsheng; Zhang, Yao; Luο, Xingguang; Xin, Hongliang

doi:10.1007/s12274-021-3395-y

Cited by 18 publications

(14 citation statements)

References 43 publications

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“…The liposome is considered a ready-to-use dosage form since the ingredients such as phospholipids, cholesterol and tocopheryl derivatives. In a recent work, Liu et al designed liposomal puerarin as anti-inflammatory targeting vehicle for the therapy of cerebral ischemia-reperfusion injury [ 38 ]. They discovered that neutrophils can carry those liposomal puerarin to the wound site where massive inflammatory reactions are prevailing.…”

Section: Discussionmentioning

confidence: 99%

Cytoprotective Effect of Liposomal Puerarin on High Glucose-Induced Injury in Rat Mesangial Cells

et al. 2021

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In diabetic patients, high glucose and high oxidative states activate gene expression of transforming growth factor beta (TGF-β) and further translocate Smad proteins into the nucleus of renal cells. This signal pathway is characterized as the onset of diabetic nephropathy. Puerarin is an active ingredient extracted from Pueraria lobata as an anti-hyperglycemic and anti-oxidative agent. However, the poor oral availability and aqueous solubility limit its pharmaceutical applications. The present paper reports the liposomal puerarin and its protective effect on high glucose-injured rat mesangial cells (RMCs). The purity of puerarin extracted from the root of plant Pueraria lobata was 83.4% as determined by the high-performance liquid chromatography (HPLC) method. The liposomal puerarin was fabricated by membrane hydration followed by ultrasound dispersion and membrane extrusion (pore size of 200 nm). The fabricated liposomes were examined for the loading efficiency and contents of puerarin, the particle characterizations, the radical scavenge and the protective effect in rat mesangial cells, respectively. When the liposomes were subjected to 20 times of membrane extrusion, the particle size of liposomal puerarin can be reduced to less than 200 nm. When liposomal puerarin in RMCs in high glucose concentration (33 mM) was administered, the over-expression of TGF-β and the nuclear translocation of Smad 2/3 proteins was both inhibited. Therefore, this study successfully prepared the liposomal puerarin and showed the cytoprotective effect in RMCs under high glucose condition.

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Section: Discussionmentioning

confidence: 99%

Cytoprotective Effect of Liposomal Puerarin on High Glucose-Induced Injury in Rat Mesangial Cells

et al. 2021

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“…Meanwhile, in one study, chemotaxis of neutrophils to inflammatory cytokines facilitated drug delivery to the ischemic penumbra site. Neutrophils were used as supporters to improve the osmosis of puerarin liposomes into the BBB and increase the consistence of puerarin in the brain parenchyma [ 170 ]. In addition, Paeoniflorin, menthol, borneol, and α-asarum are all effective adjuvants to deliver puerarin to the brain [ 171 ].…”

Section: A New Drug Delivery System For Puerarinmentioning

confidence: 99%

Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin

Wang

et al. 2022

Antioxidants

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As a kind of medicine and food homologous plant, kudzu root (Pueraria lobata (Willd.) Ohwi) is called an “official medicine” in Chinese folk medicine. Puerarin is the main active component extracted from kudzu root, and its structural formula is 8-β-D-grapes pyranose-4, 7-dihydroxy isoflavone, with a white needle crystal; it is slightly soluble in water, and its aqueous solution is colorless or light yellow. Puerarin is a natural antioxidant with high health value and has a series of biological activities such as antioxidation, anti-inflammation, anti-tumor effects, immunity improvement, and cardio-cerebrovascular and nerve cell protection. In particular, for the past few years, it has also been extensively used in clinical study. This review focuses on the antioxidant activity of puerarin, the therapy of diverse types of inflammatory diseases, various new drug delivery systems of puerarin, the “structure-activity relationship” of puerarin and its derivatives, and pharmacokinetic and clinical studies, which can provide a new perspective for the puerarin-related drug research and development, clinical application, and further development and utilization.

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“…Likewise, Dong et al presented a drug delivery system consisting of neutrophil membrane-derived nanovesicles loaded with Resolvin D2 (RvD2) to enhance resolution of inflammation, thereby protecting against brain injury caused by IS [ 189 ]. Recently, our group exploited neutrophils as carriers for facilitating the BBB penetration of liposomes loaded with puerarin and elevating the puerarin concentration within the brain parenchyma [ 190 ]. The results indicated that puerarin-loaded liposomes could be released in response to inflammation-related conditions correlated to brain injury to enhance the neuro-protection effect of ischemic penumbra.…”

Section: The Application Of Nanocarriers In Is Treatmentmentioning

confidence: 99%

Advances of nano drug delivery system for the theranostics of ischemic stroke

Liu

et al. 2022

J Nanobiotechnol

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From the global perspective, stroke refers to a highly common cause of disability and death. Ischemic stroke (IS), attributed to blood vessel blockage, preventing the flow of blood to brain, acts as the most common form of stroke. Thus far, thrombolytic therapy is the only clinical treatment for IS with the approval from the FDA. Moreover, the physiology barrier complicates therapeutically and diagnostically related intervention development of IS. Accordingly, developing efficient and powerful curative approaches for IS diagnosis and treatment is urgently required. The advent of nanotechnology has brought dawn and hope to better curative and imaging forms for the management of IS. This work reviews the recent advances and challenges correlated with the nano drug delivery system for IS therapy and diagnosis. The overview of the current knowledge of the important molecular pathological mechanisms in cerebral ischemia and how the drugs cross the blood brain barrier will also be briefly summarized. Graphical Abstract

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Enhanced treatment for cerebral ischemia-reperfusion injury of puerarin loading liposomes through neutrophils-mediated targeted delivery

Cited by 18 publications

References 43 publications

Cytoprotective Effect of Liposomal Puerarin on High Glucose-Induced Injury in Rat Mesangial Cells

Cytoprotective Effect of Liposomal Puerarin on High Glucose-Induced Injury in Rat Mesangial Cells

Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin

Advances of nano drug delivery system for the theranostics of ischemic stroke

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