Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine β and γ proteins

Owen, James D.; Strieter, Robert M.; Burdick, Marie D.; Haghnegahdar, Hamid; Nanney, Lillian B.; Shattuck-Brandt, Rebecca L.; Richmond, Ann

doi:10.1002/(sici)1097-0215(19970926)73:1<94::aid-ijc15>3.0.co;2-5

Cited by 111 publications

(71 citation statements)

References 29 publications

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“…An increase in vascularity is associated with tumor progression in melanocytic lesions from benign melanocytic nevi to MM (21). MGSA is suggested not only to affect melanocytic growth (autocrine) but also to facilitate tumor growth by stimulating angiogenesis (paracrine) that can be inhibited with antibodies to MGSA (5,6). Proliferative activity, assessed by Ki-67 monoclonal antibody, has a strong direct correlation with the number of small vessels at the base of melanocytic skin tumors (22).…”

Section: Discussionmentioning

confidence: 99%

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Melanoma Growth Stimulatory Activity in Primary Malignant Melanoma: Prognostic Significance

et al. 2002

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Section: Discussionmentioning

confidence: 99%

“…Three human MGSA/GRO genes encode three highly related chemokines, MGSA-␣, -␤, and -␥. All bind to the same receptor with different affinities and stimulate chemotaxis, angiogenesis, and growth regulation (5,6). The role of MGSA-␣ as an essential auto-stimulatory growth factor for melanoma cells is inhibited by preventing binding to its receptors (7).…”

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confidence: 99%

Melanoma Growth Stimulatory Activity in Primary Malignant Melanoma: Prognostic Significance

et al. 2002

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“…First isolated from the supernatants of a human melanoma cell line (Richmond et al, 1983), and later detected in melanoma primary cell cultures, these factors stimulate melanocyte growth, angiogenesis, and neutrophil chemotaxis. In addition, overexpression of MGSA/GRO in normal melanocytes leads to anchorage-independent growth in soft agar and tumors in nude mice (Owen et al, 1997). Also, blocking the binding of MGSA/GRO to melanoma cells led to growth inhibition that could be overcome by an excess of MGSA/GRO (Hayashi et al, 1997).…”

Section: Growth Factorsmentioning

confidence: 99%

Oncogenes in melanoma

2003

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Transformation of normal melanocytes into melanoma cells is accomplished by the activation of growth stimulatory pathways, typically leading to cellular proliferation, and the inactivation of apoptotic and tumor suppressor pathways. Small molecule inhibitors of proteins in the growth stimulatory pathways are under active investigation, and their application to melanoma patients would represent a new treatement strategy to inhibit cell proliferation or induce cell death. We provide a general overview of the mechanisms of oncogene activation and the functions of oncogenes. Lastly, we review oncogenic events in melanoma.

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“…For example, expression of angiogenic chemokines (CXCL2, CXCL3 and CXCL8/IL8) that are potent promoters of angiogenic activity were up-regulated whereas CXCL10 (an interferon-inducible chemokine), a potent inhibitor of angiogenesis was suppressed. The contribution of CXCL1, 2, and 3 to angiogenesis and tumor progression has been shown in immortalized murine melanocytes (Luan et al, 1997;Owen et al, 1997). Elevation of tumor associated CXCL8/IL8 within tumors correlates with neovascularization and is inversely correlated with survival in patients with ovarian carcinoma and non-small-lung cell carcinoma (Smith et al, 1994;Yoneda et al, 1998), whereas CXCL10 mediates its angiostatic activity via CXCR3 on endothelium (Strieter et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Transcriptional Profiles of Peripheral Blood Leukocytes Identify Patients with Cholangiocarcinoma and Predict Outcome

Subimerb¹,

Wongkham²,

Khuntikeo³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cholangiocarcinoma (CCA), a slow growing but highly metastatic tumor, is highly prevalent in Northeast Thailand. Specific tests that predict prognosis of CCA remain elusive. The present study was designed to investigate whether peripheral blood leukocyte (PBL) transcriptional profiles might be of use as a prognostic test in CCA patients. Gene expression profiles of PBLs from 9 CCA and 8 healthy subjects were conducted using the Affymetrix HG_U133 Plus 2.0 GeneChip. We indentified informative PBLs gene expression profiles that could reliably distinguish CCA patients from healthy subjects. Of these CCA specific genes, 117 genes were up regulated and 60 were down regulated. The molecular and cellular functions predicted for these CCA specific genes according to the Gene Ontology database indicated differential PBL expression of host immune response and tumor progression genes (EREG, TGF β1, CXCL2, CXCL3, IL-8, and VEGFA). The expression levels of 9 differentially expressed genes were verified in 36 CCA vs 20 healthy subjects. A set of three tumor invasion related genes (PLAU, CTSL and SERPINB2) computed as "prognostic index" was found to be an independent and statistically significant predictor for CCA patient survival. The present study shows that CCA PBLs may serve as disease predictive clinically accessible surrogates for indentifying expressed genes reflective of CCA disease severity.

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Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine β and γ proteins

Cited by 111 publications

References 29 publications

Melanoma Growth Stimulatory Activity in Primary Malignant Melanoma: Prognostic Significance

Melanoma Growth Stimulatory Activity in Primary Malignant Melanoma: Prognostic Significance

Oncogenes in melanoma

Transcriptional Profiles of Peripheral Blood Leukocytes Identify Patients with Cholangiocarcinoma and Predict Outcome

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