Enhanced Visible‐Light Photocatalytic Performance of Nanosized Anatase TiO₂ Doped with CdS Quantum Dots for Cancer‐Cell Treatment

Abstract

CdS quantum-dots-(QDs-)dopedTiO2nanocomposites were successfully synthesized using the sol-gel technique and characterized by SEM, TEM, XRD, EDS, UV-Vis, and FS. They were then used as a new “photosensitizer” based on photodynamic therapy (PDT) for cancer-cell treatment. The photocatalytic activities of CdS-TiO2on leukemia tumors were investigated by using Cell Counting Kit-8 (CCK-8) assay. The ultrastructural morphology of treated cells was also studied by AFM. The experimental results indicated that an obvious inhibition of tumor growth would be observed in groups treated with CdS-TiO2nanocomposites, and the PDT efficiency in the presence of CdS-dopedTiO2was significantly higher than that ofTiO2, revealing that the photocatalytic activities ofTiO2could be effectively enhanced by the modification of CdS QDs. Additionally, CdS-TiO2can exhibit a very high photodynamic efficiency of 80.5% at a final concentration of 200μg/mL under visible-light irradiation. CdS-TiO2nanocomposites in this case were regarded as a promising application for cancer-cell treatment.

The Comparative PDT Experiment of the Inactivation of HL60 on Modified TiO2 Nanoparticles

“…Other modified TiO 2 nanoparticles such as N-TiO 2 , Er 3+ -Yb 3+ -Fe 3+ tridoped TiO 2 , and Au/TiO 2 had been proved to have higher photocatalytic effect than pure TiO 2 on tumor cell [15][16][17][18]. Our laboratory had made some progress on tests of in vitro PDT based on modified TiO 2 such as CdS doped TiO 2 , Fe-N codoped TiO 2 , and TiO 2 -xNx [19,20].…”

Tailoring Cadmium Composition on Titanium Dioxide to Achieve Enhanced Photocatalytic Glucose Fuel Cell Anode Performance

“…Furthermore, there is no corresponding peak for Cd; this may be attached to the fact that the amount of Cd is very small and is well dispersed in TiO 2 . Huang et al investigated the crystalline structural properties of CdS-doped TiO 2 by XRD analysis. They attributed that there was no peak due to the small amount of CdS and dispersed well into TiO 2 .…”

Ag/AgFeO2: An Outstanding Magnetically Responsive Photocatalyst for HeLa Cell Eradication

“…Over the past few years, applications of photocatalysts in cancer cell treatment grab the attention of researchers in the area and emerge as a promising alternative to the traditional cancer treatment options that suffer from severe side effects. 9 − 13 …”

“…A suitable level of ROS is necessary for cell survival, while excessive amounts of ROS can trigger cell apoptosis through damaging the membrane and interior of the cells. Over the past few years, applications of photocatalysts in cancer cell treatment grab the attention of researchers in the area and emerge as a promising alternative to the traditional cancer treatment options that suffer from severe side effects. − …”