Enhanced volumetric visualization for real time 4D intraoperative ophthalmic swept-source OCT

Viehland, Christian; Keller, Brenton; Carrasco-Zevallos, Oscar; Nankivil, Derek; Shen, Liangbo; Mangalesh, Shwetha; Viet, Du Tran; Kuo, Anthony N.; Toth, Cynthia A.; Izatt, Joseph A.

doi:10.1364/boe.7.001815

Cited by 54 publications

(44 citation statements)

References 51 publications

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“…These solutions only provide 2D cross-sectional images due to limited speed. With faster systems, 4D visualization provides a wealth of additional data [190], supporting surgeons [191] and showing structures invisible with the standard operating microscope [192]. In future, those systems could expand the surgeon's capabilities and the quality of the intervention.…”

Section: Applicationsmentioning

confidence: 99%

High-speed OCT light sources and systems [Invited]

Klein¹,

Huber²

2017

Biomed. Opt. Express

201

111

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Abstract:Imaging speed is one of the most important parameters that define the performance of optical coherence tomography (OCT) systems. During the last two decades, OCT speed has increased by over three orders of magnitude. New developments in wavelength-swept lasers have repeatedly been crucial for this development. In this review, we discuss the historical evolution and current state of the art of high-speed OCT systems, with focus on wavelength swept light sources and swept source OCT systems. 3067-3086 (2012). 7. J. Xu, X. Wei, L. Yu, C. Zhang, J. Xu, K. K. Y. Wong, and K. K. Tsia, "High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch," Biomed. Opt. Express 6(4), 1340-1350 (2015). 8. D. J. Fechtig, B. Grajciar, T. Schmoll, C. Blatter, R. M. Werkmeister, W. Drexler, and R. A. Leitgeb, "Line-field parallel swept source MHz OCT for structural and functional retinal imaging," Biomed. Opt. Express 6(3), 716-735 (2015). 9. T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, "Multi-MHz retinal OCT," Biomed.Opt. Express 4(10), 1890-1908 (2013). 10. E. A. Swanson, D. Huang, M. R. Hee, J. G. Fujimoto, C. P. Lin, and C. A. Puliafito, "High-speed optical coherence domain reflectometry," Opt. Lett. 17(2), 151-153 (1992). 11. G. J. Tearney, B. E. Bouma, S. A. Boppart, B. Golubovic, E. A. Swanson, and J. G. Fujimoto, "Rapid acquisition of in vivo biological images by use of optical coherence tomography," Opt. Lett. 21(17), 1408-1410 (1996). 12. G. J. Tearney, B. E. Bouma, and J. G. Fujimoto, "High-speed phase-and group-delay scanning with a gratingbased phase control delay line," Opt. Lett. 22(23), 1811-1813 (1997). 13. A. Rollins, S. Yazdanfar, M. Kulkarni, R. Ung-Arunyawee, and J. Izatt, "In vivo video rate optical coherence tomography," Opt. Express 3(6), 219-229 (1998). 14. G. Häusler and M. W. Lindner, "Coherence radar and 'spectral radar'-new tools for dermatological diagnosis," J.Biomed. Opt. 3(1), 21-31 (1998). 15. B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, "Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr4+:forsterite laser," Opt. Lett. 22(22), 1704-1706 (1997). 16. S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, "Optical coherence tomography using a frequency-tunable optical source," Opt. Lett. 22(5), 340-342 (1997). 17. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7(3), 457-463 (2002). 18. L. Kranendonk, R. Bartula, and S. Sanders, "Modeless operation of a wavelength-agile laser by high-speed cavity length changes," Opt. Express 13(5), 1498-1507 (2005). 656-664 (2012). 36. C. Henry, "Theory of the linewidth of semiconductor lasers," IEEE J. Quantum Electron. 18(2), 259-264 (1982). 37. J. Geng, Q. Wang, J. Wang, S. Jiang, and K. Hsu, "All-fiber wavelength-swept laser near 2 μm," Opt. Lett. 3771-3773 (2011). 38. F. Nielsen, L. Thrane, J. Black, A. Bjarklev, and P. Ander...

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Section: Applicationsmentioning

confidence: 99%

High-speed OCT light sources and systems [Invited]

Klein¹,

Huber²

2017

Biomed. Opt. Express

201

111

View full text Add to dashboard Cite

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“…GPUs were primarily used for rendering graphics prior to the advent of high level GPU programming languages such as NVIDIA's compute unified device architecture (CUDA) [134]. For OCT in particular, GPU processing became highly desirable as the repetition rate of OCT lasers increased to kilohertz [35,114,[135][136][137][138] and even megahertz [34], and researchers were no longer able to process OCT data on the CPU in real-time. Moreover, GPUs also allowed real-time volume rendering for visualization and manipulation of OCT 3D and 4D (volumes over time) data.…”

Section: Live 3d Microscope-integrated Octmentioning

confidence: 99%

“…Similar to previous 4D OCT systems, the swept-source 4D MIOCT software exploited the speed of GPUs for acquisition, processing, and volumetric rendering [136]. Unlike previous 4D OCT demonstrations, however, the ray casting algorithm used for volume rendering was optimized specifically to enhance the visualization of subtle ocular structures and surgically-induced alterations [137] (Fig. 7(a)).…”

Section: Live 3d Microscope-integrated Octmentioning

confidence: 99%

Review of intraoperative optical coherence tomography: technology and applications [Invited]

Carrasco-Zevallos

Viehland

Keller

et al. 2017

Biomed. Opt. Express

Self Cite

140

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During microsurgery, en face imaging of the surgical field through the operating microscope limits the surgeon's depth perception and visualization of instruments and subsurface anatomy. Surgical procedures outside microsurgery, such as breast tumor resections, may also benefit from visualization of the sub-surface tissue structures. The widespread clinical adoption of optical coherence tomography (OCT) in ophthalmology and its growing prominence in other fields, such as cancer imaging, has motivated the development of intraoperative OCT for real-time tomographic visualization of surgical interventions. This article reviews key technological developments in intraoperative OCT and their applications in human surgery. We focus on handheld OCT probes, microscope-integrated OCT systems, and OCT-guided laser treatment platforms designed for intraoperative use. Moreover, we discuss intraoperative OCT adjuncts and processing techniques currently under development to optimize the surgical feedback derivable from OCT data. Lastly, we survey salient clinical studies of intraoperative OCT for human surgery.

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“…While doctors are capable of interpreting crosssectional OCT slices, there is nevertheless a need for en face views, as shown by the continued use of en face techniques such as fundus cameras or SLO. Thanks to the speed improvement, OCT systems can provide en face retinal images by doing real-time 3Dimaging [10][11][12]. Nevertheless, due to the requirement of large depth of focus, low NA is typically used in traditional OCT, resulting in relatively low spatial resolution compared with high-NA systems.…”

mentioning

confidence: 99%

“…imaging [10][11][12]. Nevertheless, due to the requirement of large depth of focus, low NA is typically used in traditional OCT, resulting in relatively low spatial resolution compared with high-NA systems.…”

mentioning

confidence: 99%

In vivo high-resolution human retinal imaging with wavefront-correctionless full-field OCT

Xiao¹,

Mazlin²,

Grieve³

et al. 2018

Optica

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As the lateral resolution of full-field optical coherence tomography (FFOCT) with spatially incoherent illumination has been shown to be insensitive to aberrations, we demonstrate high-resolution en face FFOCT retinal imaging without wavefront correction in the human eye in vivo for the first time, to our knowledge. A combination of FFOCT with spectraldomain OCT (SDOCT) is applied for real-time matching of the optical path lengths (OPLs) of FFOCT. Through the realtime cross-sectional SDOCT images, the OPL of the FFOCT reference arm is matched with different retinal layers in the FFOCT sample arm. Thus, diffraction-limited FFOCT images of multiple retinal layers are acquired at both the near periphery and the fovea. The en face FFOCT retinal images reveal information about various structures, such as the nerve fiber orientation, the blood vessel distribution, and the photoreceptor mosaic. During its 25 years of development, optical coherence tomography (OCT) has become a powerful imaging modality in biomedical and clinical studies [1,2]. It has achieved great success in ophthalmology [3], especially in retinal imaging for which it has been entitled the "virtual biopsy" for human retina [4]. Compared with typical retinal imaging modalities like fundus cameras [5] or scanning laser ophthalmoscopy (SLO) [6], in which axial resolution is limited by the finite size of the eye's pupil, OCT offers much higher axial sectioning, as the lateral and axial resolutions are decoupled. The high-resolution cross-sectional depth exploration of the retinal layers offers important information about pathologies for early diagnosis of disease and for tracing disease evolution [7][8][9]. While doctors are capable of interpreting crosssectional OCT slices, there is nevertheless a need for en face views, as shown by the continued use of en face techniques such as fundus cameras or SLO. Thanks to the speed improvement, OCT systems can provide en face retinal images by doing real-time 3Dimaging [10][11][12]. Nevertheless, due to the requirement of large depth of focus, low NA is typically used in traditional OCT, resulting in relatively low spatial resolution compared with high-NA systems. To ensure high transverse resolution, en face flying spot OCT has been applied for human retinal imaging, which achieves retinal en face images with transverse scanning [13,14]. To be able to realize close to diffraction-limited lateral resolution in OCT retinal imaging, complex hardware adaptive optics (AO) [15][16][17][18][19] or computational AO [20][21][22] would also be needed to correct the aberrations induced by the imperfections of the cornea and lens in the anterior chamber.Full-field OCT (FFOCT) is a kind of time-domain en face parallel OCT that takes images perpendicular to the optical axis without scanning. By using high-NA microscope objectives in a Linnik interferometer, FFOCT is able to achieve standard microscope spatial resolution [23]. With spatially incoherent illumination, cross talk is severely inhibited in FFOCT compared with wide-...

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Enhanced volumetric visualization for real time 4D intraoperative ophthalmic swept-source OCT

Cited by 54 publications

References 51 publications

High-speed OCT light sources and systems [Invited]

High-speed OCT light sources and systems [Invited]

Review of intraoperative optical coherence tomography: technology and applications [Invited]

In vivo high-resolution human retinal imaging with wavefront-correctionless full-field OCT

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