Enhanced water-solubility and antibacterial activity of novel chitosan derivatives modified with quaternary phosphonium salt

Zhu, Dan; Cheng, Honghao; Li, Jianna; Zhang, Wenwen; Shen, Yuanyuan; Chen, Heng; Zhang, Ge

doi:10.1016/j.msec.2015.12.024

Cited by 122 publications

(55 citation statements)

References 32 publications

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“…On the other hand, Zhu et al [155], prepared a series of water-soluble chitosan derivatives bearing quaternary phosphonium salts (Figure 11). The different derivatives were shown to have antimicrobial activity towards two different bacterial strains ( E. coli and S. aureus ).…”

Section: Polymeric Biocidesmentioning

confidence: 99%

Recent Developments in Antimicrobial Polymers: A Review

et al. 2016

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Antimicrobial polymers represent a very promising class of therapeutics with unique characteristics for fighting microbial infections. As the classic antibiotics exhibit an increasingly low capacity to effectively act on microorganisms, new solutions must be developed. The importance of this class of materials emerged from the uncontrolled use of antibiotics, which led to the advent of multidrug-resistant microbes, being nowadays one of the most serious public health problems. This review presents a critical discussion of the latest developments involving the use of different classes of antimicrobial polymers. The synthesis pathways used to afford macromolecules with antimicrobial properties, as well as the relationship between the structure and performance of these materials are discussed.

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Section: Polymeric Biocidesmentioning

confidence: 99%

Recent Developments in Antimicrobial Polymers: A Review

et al. 2016

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“…However, the antibacterial properties of the CS–GE films were shown to be poor by previous research, which results from the presence of fewer effective antibacterial groups after numerous hydrogen bonds were formed between the hydroxylamines and carbonyls in GE and CS (Pérez‐Córdoba et al., ). In addition, the antibacterial and anticorrosive properties of CS were also limited by the degree of acetylation, molecular weight, environment effects, and so on (Zhu et al., ). An approach to improve the antimicrobial activity is adding certain antibacterial substances, such as nanoparticles, proteins, oleic acid, and plant essential oils, into film‐forming solutions.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Chitosan‐Based Ternary Blend Edible Films with Efficient Antimicrobial Activities for Food Packaging Applications

Guo

Chen

Yang

et al. 2019

Journal of Food Science

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To improve the mechanical and antibacterial properties of chitosan (CS) films, a ternary blend edible film was prepared by incorporating CS, gelatin (GE), and natural cinnamon essential oil (CEo). Scanning electron microscopy (SEM), Atomic force microscopy (AFM), Fourier transform infrared spectroscopy, and X‐ray diffraction were performed to evaluate the films. The mechanical properties, light transmission, thermal stability, hydrophilicity, and antibacterial activity of the films were also determined. The results confirmed all of the films exhibited excellent UV protection with low transparency at 600 nm. Compared with the CS films, the ternary composite film (CSGEo film, containing CS, GE, and CEo) had a higher elongation at break but a lower tensile strength. SEM images revealed that all films had smooth surfaces, although some obvious differences between CS and CSGEo films were observed by AFM. Additionally, the incorporation of GE and CEo to the films enhanced their thermal stability and contact angle, but decreased their crystallinity and wettability. The antimicrobial activity results showed that CSGEo films had excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus, for which the antibacterial rate exceeded 98%. The minimum inhibitory concentrations of the CSGEo solution against E. coli and S. aureus were both 52.06 µg/mL, and the minimal bactericidal concentrations were 104.12 and 52.06 µg/mL, respectively. These results suggest that CSGEo films possess good mechanical and antibacterial properties, and therefore, their application in the food packaging industry is promising. Practical Application The main raw materials of the edible films developed in this study are aquatic by‐products, so the films are edible and biodegradable. The addition of gelatin and CEo improved the UV barrier and thermal properties but decreased the crystallinity and hydrophilicity of the films, making them suitable for use as packaging materials. CEo‐incorporated films exhibited excellent mechanical properties and antibacterial activity and can, therefore, be used in the food packaging industry.

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“…Zhu et al . () prepared chitosan derivatives through quaternary phosphonium and enhanced water solubility pH ranging from 2 to 12. Compared to previous reports, the current study adapted relatively low toxic chemicals for the preparation of modified chitosan.…”

Section: Resultsmentioning

confidence: 99%

“…Chen et al (2016) synthesised N-quaternary ammonium-O-sulfobetaine-chitosan and enhanced water solubility ranging from pH 3.0 to 11.0. Zhu et al (2016) prepared chitosan derivatives through quaternary phosphonium and enhanced water solubility pH ranging from 2 to 12. Compared to previous reports, the current study adapted relatively low toxic chemicals for the preparation of modified chitosan.…”

Section: Solubility In Water and Oil-entrapped Ability Of The Modifiementioning

confidence: 99%

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Modification of chitosan using hydrogen peroxide and ascorbic acid and its physicochemical properties including water solubility, oil entrapment and in vitro lipase activity

Hong

Choi

et al. 2019

Int J of Food Sci Tech

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Summary Chitosan was modified using H2O2 and ascorbic acid with different incubation temperatures (4–40 °C). The properties of modified chitosan, including its oil entrapment ability, water solubility and the lipase‐resistant activities, using in vitro intestine model system were determined. Nuclear magnetic resonance analysis showed that ascorbic acid was bound to modified chitosan. All of the modified chitosan from 4 to 40 °C demonstrated improved water solubility (even in pH 7) compared to non‐modified chitosan, which was only soluble at pH 4. Modified chitosan from 4 °C exhibited 27.40% of oil entrapment ability which was approximately four times higher than 6.87% of non‐modified chitosan. Modified chitosan from 4 and 40 °C had increased resistance against lipase activity compared to other biopolymers, including beeswax, carnauba wax and non‐modified chitosan. Modified chitosan could be used as a new food ingredient due to their high water solubility, oil‐entrapping ability and resisting lipase activity.

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Enhanced water-solubility and antibacterial activity of novel chitosan derivatives modified with quaternary phosphonium salt

Cited by 122 publications

References 32 publications

Recent Developments in Antimicrobial Polymers: A Review

Recent Developments in Antimicrobial Polymers: A Review

Preparation and Characterization of Chitosan‐Based Ternary Blend Edible Films with Efficient Antimicrobial Activities for Food Packaging Applications

Modification of chitosan using hydrogen peroxide and ascorbic acid and its physicochemical properties including water solubility, oil entrapment and in vitro lipase activity

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