One of the biggest environmental challenges that most of the traditional and modern grape-growing areas are facing is the frequency, severity, and unpredictability of extreme weather events as a result of climate change. Sustainable tools such as chemically inert mineral particles could be a valid alternative for the promotion of environmentally-friendly viticultural techniques to enhance yield, improve physiological processes, and increase tolerance to biotic/abiotic stressors and grape quality. In regard to this concept, the effects of kaolin (KL) and zeolite (ZL) application was tested in the rosé grapevine cultivar Roditis, field-and rainfed, under the Mediterranean conditions of central Greece. In a two-year trial, the whole vine canopy was sprayed with kaolin and zeolite until runoff at a dose of 3% (w/v) twice throughout the growing season; the first at the beginning of veraison and the second one week later; treatment of the untreated control plants was also performed (C). The assimilation rate in morning and midday, the stomatal conductance, and the WUEi of the leaves of the treated and untreated plants were monitored one day after each application and at harvest. During the same time period of the day (i.e., morning and midday) in July, August, and September, the leaf temperature near the fruit zone was also recorded. At harvest, the yield parameters, cluster characteristics, grape composition, and incidence (%) of sunburned and dehydrated berries as well as berries infected by Plasmopara viticola and Lobesia botrana were recorded. The results showed that KL and ZL application decreased leaf temperature during the growing season until harvest compared to the control treatment, which resulted in an improvement in physiological parameters such as net photosynthesis and intrinsic water use efficiency. At harvest, the KL- and ZL-treated vines showed increased yield due to an increasing cluster and berry fresh weight. On the other hand, the KL and ZL application did not affect the sugar concentration and pH of the must and increased the total acidity and decreased the total phenolic compound content, but only in the first year of the experiments. Furthermore, the incidence of sunburn necrosis, dehydrated berries, and infected berries was significantly lower in the treated vines compared to the control vines. These results confirm the promising potential of kaolin and zeolite applications as a stress mitigation strategy during the summer period, with the ability to protect grapevine plants, enhance yield, and maintain or improve fruit quality in rainfed Mediterranean vineyards.