Enhancement of Antioxidant and Hydrophobic Properties of Alginate via Aromatic Derivatization: Preparation, Characterization, and Evaluation

Abstract

The preparation of bioactive polymeric molecules requires the attention of scientists as it has a potential function in biomedical applications. In the current study, functional substitution of alginate with a benzoyl group was prepared via coupling its hydroxyl group with benzoyl chloride. Fourier transform infrared spectroscopy indicated the characteristic peaks of aromatic C=C in alginate derivative at 1431 cm−1. HNMR analysis demonstrated the aromatic protons at 7.5 ppm assigned to benzoyl groups attached to alginate hydroxyl groups. Wetting analysis showed a decrease in hydrophilicity in the new alginate derivative. Differential scanning calorimetry and thermal gravimetric analysis showed that the designed aromatic alginate derivative demonstrated higher thermo-stability than alginates. The aromatic alginate derivative displayed high anti-inflammatory properties compared to alginate. Finally, the in vitro antioxidant evaluation of the aromatic alginate derivative showed a significant increase in free radical scavenging activity compared to neat alginate against DPPH (2,2-diphenyll-picrylhydrazyl) and ABTS free radicals. The obtained results proposed that the new alginate derivative could be employed for gene and drug delivery applications.

In vivo Evaluation of the Antipsoriatic Effect of Alginate Hydrogel with Lavandin Essential Oil and Its Main Components after Topical Application

“…A similar effect was observed in our previous experiment, when a hydrogel placebo containing sodium alginate was applied on mice paws and ears during evaluation of the anti-in ammatory and antiallergic activity of cynaroside [30]. Elbayomi et al reported that alginates anti-in ammatory properties can be linked to the presence of Dmannuronic acid, one of the new established nonsteroidal anti-in ammatory drugs [31]. It was also noted that alginates, per se, inhibit the production and secretion of in ammatory mediators, such as nitric oxide (NO), tumour necrosis factor (TNF), prostaglandin E2 (PGE2), and interleukins (ILs).…”

Characterization and Bioactivity of Polysaccharides Separated through a (Sequential) Biorefinery Process from Fucus spiralis Brown Macroalgae

“…Alginate is a marine polysaccharide found in macroalgae, as well as other marine organisms. Its structure comprises homogenous or heterogenous disposition of β-D-mannuronic acid (M) and α-L-guluronic acid (G) [ 107 ]. Spectral analysis of E 3 ( Figure 4 ) identified the presence of guluronic units (G) at 1017 cm −1 [ 96 , 97 , 99 ] and mannuronic units (M) at 872 and 812 cm −1 [ 97 , 99 ], confirming the isolation of alginate.…”

Valorization of Aquatic Weed and Agricultural Residues for Innovative Biopolymer Production and Their Biodegradation

“…For thermal property, bioplastics were tested in their stability by using Differential Scanning Calorimeters (Shimadzu DSC-60A, Kyoto, Japan) [ 22 ]. In brief, 10 mg bioplastic sample was prepared and placed in an aluminum dish and packed into the designated position inside the Differential Scanning Calorimeters device (DSC).…”