2010
DOI: 10.1038/cmi.2009.117
|View full text |Cite
|
Sign up to set email alerts
|

Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatorycells

Abstract: Low-dose total body irradiation (LTBI) is used in the treatment of some cancers mainly for immune enhancement rather than cell killing. However, the mechanism underlying LTBI remains unknown. In this study, by analyzing the immune patterns of lymphocytes, we found that the percentage and absolute number of CD4 1 CD25 1 Foxp3 1 regulatory T cells are markedly decreased in naive mice following treatment with LTBI. On the contrary, the CD4 1 CD44 1 /CD8 1 CD44 1 effector-memory T cells are greatly increased. Impo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
66
1

Year Published

2010
2010
2023
2023

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 74 publications
(68 citation statements)
references
References 23 publications
1
66
1
Order By: Relevance
“…[26][27][28]55,56 The inconsistencies may be due to differences in animal models, cell samples, radiation ratios and observation time points. Understanding the reasons for the inconsistent data in the future is essential.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…[26][27][28]55,56 The inconsistencies may be due to differences in animal models, cell samples, radiation ratios and observation time points. Understanding the reasons for the inconsistent data in the future is essential.…”
Section: Discussionmentioning
confidence: 99%
“…24,25 Recently, it was reported by us and others that the newly identified immunosuppressive CD4 1 CD25 1 Treg cells displayed different radiation sensitivities compared with CD4 1 CD25 2 T effector cells in vivo. [26][27][28][29] However, the peripherally changed levels of CD4 1 CD25 1 Treg cells after WBI was due to the direct effect of ionizing irradiation on peripheral T cells and on the thymus function whether has not been addressed. In the present study, we investigated the sensitivity of mouse CD4 1 CD25 1 Treg cells to c-rays in naive, immunized and thymectomized mice.…”
Section: Introductionmentioning
confidence: 99%
“…Last but not least, low-dose total body irradiation therapy also reduced Tregs and increased effector-memory T-cell frequencies. Administration of a DC-gp100 tumor vaccine 11 days after low dose irradiation reduced tumor outgrowth and increased survival of melanoma-bearing mice [49]. Taken together, altering Treg function or depleting Tregs may improve tumor-specific immune responses and expand the efficacy of immunotherapy (reviewed in [105]).…”
Section: Other Interventions Applied Before Vaccination That Reduce Imentioning
confidence: 99%
“…The inhibition effects of low dose radiation on tumor growth were gained by the enhancement of immune function that was through the whole regulation of every system of organism, not through directly killing tumor cells by radiation. As reported by Liu et al (2010), low dose radiation could accelerate the production, maturation and renewal of immune cells and then enhance immune function of organism. Another possible mechanism was the relieving inhibition of immune system through downreguation of hypothalamus-pituitary-adrenal axis after low dose radiation for whole body (Reissfelder et al, 2011).…”
Section: Discussionmentioning
confidence: 99%