Enhancement of aphrodisiac activity in male rats by ethanol extract of Kaempferia parviflora and exercise training

Chaturapanich, Ganyapong; Chaiyakul, Salinee; Verawatnapakul, V.; Yimlamai, Tossaporn; Pholpramool, Chumpol

doi:10.1111/j.1439-0272.2011.01184.x

Cited by 26 publications

(17 citation statements)

References 33 publications

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“…KP treatment significantly increased serum testosterone levels and enhanced sexual behaviour in STZ‐induced diabetic rats. This is in line with other studies, which reported that KP treatment in male rats enhances sexual motivation (Chaturapanich et al., ) and that KP treatment in normal rats at 240 mg/kg led to a reduction in the time associated with courtship behaviour in the first 10 min (Sudwan et al., ). More recent research has show that the effect of KP to enhance sexual performance by increasing blood flow to the testis, enhancing NO production in medial pre‐optic area (MPOA) results, is complex sexual behaviour.…”

Section: Discussionsupporting

confidence: 92%

“…More recent research has show that the effect of KP to enhance sexual performance by increasing blood flow to the testis, enhancing NO production in medial pre‐optic area (MPOA) results, is complex sexual behaviour. Furthermore, the same study shows that 7‐methoxyflavone had an inhibitory activity against phosphodiesterase 5 (PDE5) (Chaturapanich et al., ; Chaturapanich et al., ; Temkitthawon et al., ).…”

Section: Discussionmentioning

confidence: 99%

“…KP treatment in castrated immature rats also showed no significant impact in relative reproductive and nonreproductive organ weight compared with nontreatment rats (Trisomboon, Watanabe, Wetchasit, & Taya, ). Several studies have reported that KP treatment may also elevate serum testosterone and the hormone could increase the reproductive organ weight (Chaturapanich, Chaiyakul, Verawatnapakul, Yimlamai, & Pholpramool, ; Trisomboon et al., ). Furthermore, our results are in agreement with those of previous reports, showing that KP treatment in diabetic rats increase serum testosterone level.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Kaempferia parviflora on sexual performance in streptozotocin-induced diabetic male rats

2017

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SummaryKaempferia parviflora Wall. Ex.Baker or Krachidum (KP) has been used locally in medicine and food. It has been claimed that KP has aphrodisia properties; however, no scientific data in support of this function in diabetic model have been reported. This study aimed to investigate the efficacy of KP on sexual behaviour and sperm parameter in streptozotocin (STZ)-induced diabetic male rats. Diabetes was induced in twenty male rats by STZ and divided into four groups: diabetic control group, and 3 treatment groups where KP was dose at 140, 280 and 420 mg/kg orally once a day for 6 weeks.Five normal control rats were treated with vehicle. The body weight, blood glucose, food intake, epididymal sperm parameter, sexual behaviour and serum testosterone level were evaluated. The results showed that KP treatment has no effect on the body weight, blood glucose and food intake in diabetic rats. A significant increase in sperm density in diabetic rats was observed (p < .05) at highest dose of KP. Furthermore, KP treatment demonstrated a significant recovery of sexual behaviour and serum testosterone levels in diabetic rats. These results confirm that KP exhibits aphrodisiac properties that improve the sperm density, testosterone level and sexual performance of STZ-induced diabetic rats. K E Y W O R D Sdiabetes mellitus, Kaempferia parviflora, rat, sexual performance, testoseterone

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of Kaempferia parviflora on sexual performance in streptozotocin-induced diabetic male rats

2017

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“…They concluded that alcohol extract had an aphrodisiac activity probably via a marked increase in blood flow to the testis. In another study, Chaturapanich, Chaiyakul, Verawatnapakul, Yimlamai, and Pholpramool () investigated the effects of K. parviflora extract (KD) and exercise training on reproductive function in male rats. They observed that the weights of epididymis, seminal vesicles, prostate gland and levator ani muscle were significantly increased in the exercise training with the extract treated group.…”

Section: Medicinal Plants Andplant‐derived Products Used As Aphrodisimentioning

confidence: 99%

A review of the potential of medicinal plants in the management and treatment of male sexual dysfunction

Malviya¹,

Malviya²,

Jain³

et al. 2016

Andrologia

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Male sexual dysfunction is a common disorder that appears to be a consequence of a wide range of physical and psychological conditions. Due to mental stress, insufficient physical exercise and various aetiological factors, human being's life is becoming less pleasant, which leads to incapability to have sexual pleasure. The allopathic drugs used for sexual dysfunction are believed to produce a variety of side effects and affect other physiological processes and, ultimately, general health. Therefore, the search for natural supplement from medicinal plants is being intensified probably because of less side effects availability and affordability. Ethnobotanical surveys have indicated a large number of plants traditionally used as aphrodisiacs but only few of them are scientifically validated for the management and treatment of male sexual dysfunction. This article has summarised the medicinal plants traditionally recommended and scientifically validated for the management and treatment of male sexual dysfunction.

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“…Kaempferia parviflora belongs to the Zingiberaceae family and has been used as a folk medicine and food in Thailand (Nakao et al., ). The extracts of K. parviflora rhizomes have various biological activities including: (a) inhibitory effects on P‐glycoprotein function (Patanasethanont et al., ); (b) anti‐plasmodial, anti‐fungal, and anti‐mycobacterial activities (Yenjai, Prasanphen, Daodee, Wongpanich, & Kittakoop, ); (c) cytotoxic effect on cancer cells (Yenjai & Wanich, ); (d) anti‐cholinesterase activity (Sawasdee, Sabphon, Sitthiwongwanit, & Kokpol, ); (e) anti‐allergic activity (Tewtrakul, Subhadhirasakul, & Kummee, ); (f) suppressive effect on the function of multidrug resistance‐associated protein; (g) anti‐gastric ulcer effect (Rujjanawate, Kanjanapothi, Amornlerdpison, & Pojanagaroon, ); (h) anti‐obesity effect (Akase et al., ); (i) aphrodisiac activity (Chaturapanich, Chaiyakul, Verawatnapakul, Yimlamai, & Pholpramool, ); and (j) enhancing effects on ATP production and glucose uptake in skeletal muscle cells (Toda et al., ). At least ten methoxyflavone derivatives (six 5,7‐dimethoxyflavone (DMF) derivatives and four 5‐hydroxy‐7‐methoxyflavone (HMF) derivatives) have been isolated from K. parviflora (Nakao et al., ).…”

Section: Introductionmentioning

confidence: 99%

5‐Hydroxy‐7‐methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy

Ono

Yoshida

Maekawa

et al. 2018

Food Science & Nutrition

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Skeletal muscle plays a critical role in locomotion and energy metabolism. Maintenance or enhancement of skeletal muscle mass contributes to the improvement of mobility and prevents the development of metabolic diseases. The extracts from Kaempferia parviflora rhizomes contain at least ten methoxyflavone derivatives that exhibit enhancing effects on ATP production and glucose uptake in skeletal muscle cells. In the present study, we investigated the effects of ten K. parviflora‐derived methoxyflavone derivatives (six 5,7‐dimethoxyflavone (DMF) derivatives and four 5‐hydroxy‐7‐methoxyflavone (HMF) derivatives) on skeletal muscle hypertrophy. Murine C2C12 myotubes and senescence‐accelerated mouse‐prone 1 (SAMP1) mice treated with methoxyflavones were used as experimental models to determine the effects of HMF derivatives on myotube diameter and size and muscle mass. The four HMF derivatives, but not the six DMF derivatives, increased myotube diameter. The 5‐hydroxyflavone, 7‐methoxyflavone, and 5,7‐dihydroxyflavone had no influence on myotube size, a result that differed from HMF. Dietary administration of the mixture composed of the four HMF derivatives resulted in increase in the soleus muscle size and mass in SAMP1 mice. HMF derivatives also promoted protein synthesis in myotubes, and treatment with the intracellular Ca2+ chelator BAPTA‐AM, which depletes intracellular Ca2+ levels, inhibited this promotion. Furthermore, BAPTA‐AM inhibited HMF‐promoted protein synthesis even when myotubes were incubated in Ca2+‐free medium. These results indicate that HMF derivatives induce myotube hypertrophy and that both the 5‐hydroxyl group and the 7‐methoxy group in the flavones are necessary for myotube hypertrophy. Furthermore, these results suggest that HMF‐induced protein synthesis requires intracellular Ca2+, but not extracellular Ca2+.

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Enhancement of aphrodisiac activity in male rats by ethanol extract of Kaempferia parviflora and exercise training

Cited by 26 publications

References 33 publications

Effect of Kaempferia parviflora on sexual performance in streptozotocin-induced diabetic male rats

Effect of Kaempferia parviflora on sexual performance in streptozotocin-induced diabetic male rats

A review of the potential of medicinal plants in the management and treatment of male sexual dysfunction

5‐Hydroxy‐7‐methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy

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