Enhancement of aqueous stability and fluorescence brightness of indocyanine green using small calix[4]arene micelles for near-infrared fluorescence imaging

Abstract

Incorporation of ICG into calix[4]arene micelles improves its aqueous stability and fluorescence brightness.

Photophysical Properties of Indocyanine Green in the Shortwave Infrared Region

“…In water, the Φ F we measured (2.9 %) agrees with two previous studies by Philip et al [47] . and Jin et al ., [48] and is only slightly less than Hoshi et al [49] . Particularly in water, solvent reabsorption effects may impact the accuracy of the Φ F measurement [46] .…”

BF 2 -azadipyrromethene NIR-emissive fluorophores with research and clinical potential

“…Kolliphor EL is a clinically approved agent used for the delivery of water insoluble drugs such as cyclosporine A, diazepam and paclitaxel [26]. ICG solutions gave absorption and emission maxima at 794 and 818 nm, close to literature reported values in water ( Table 2, entry 1) [25]. We were pleased to find that our new fluorophores 4 and 5 showed similar spectral properties.…”

“…In pure aqueous media, ICG 1 and fluorophores 4 and 5 showed complex spectra due to complex aggregates so 1% aqueous Kolliphor EL buffer solutions at pH 7 of each were used to allow their properties to be investigated and compared [25]. Kolliphor EL is a clinically approved agent used for the delivery of water insoluble drugs such as cyclosporine A, diazepam and paclitaxel [26].…”

Shortwave-infrared (SWIR) fluorescence molecular imaging using indocyanine green–antibody conjugates for the optical diagnostics of cancerous tumours

“…0.5%. 32 SWIR uorescence images of a capillary lled with an aqueous solution (2 mM) of ICG-Herceptin are shown in Fig. 3b.…”