Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A

Phosphatidylinositol acts through mitogen-activated protein kinase to stimulate hepatic apolipoprotein A-I secretion

“…Niacin has been shown to impact MAPK through the activation of a G-protein-coupled receptor [21] and activation of PKC [22]. Insulin is also known to stimulate apo A-I secretion through activation of PKC [23], and data from the present study suggest that PI acts similarly.…”

International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)

“…Consistent with this, HCA 2 and HCA 3 receptors, which are expressed in neutrophils, macrophages, and other immune cells, have been shown to mediate ligand-induced increases in free intracellular Ca 2ϩ concentrations in a G i /G o -dependent manner (Benyó et al, 2006;Tang et al, 2006;Kostylina et al, 2008;Ahmed et al, 2009a;Irukayama-Tomobe et al, 2009). It has been suggested that the increase in intracellular Ca 2ϩ concentrations mediated by HCA 2 receptors in response to nicotinic acid results in the activation of Ca 2ϩ -sensitive phospholipase A 2 and subsequent formation of prostanoids (Benyó et al, 2005(Benyó et al, , 2006Tang et al, 2006). This would well explain the rapid formation of prostanoids such as prostaglandins D 2 and E 2 in response to nicotinic acid (Morrow et al, 1989;Cheng et al, 2006;Maciejewski-Lenoir et al, 2006).…”

Niacin Inhibits Vascular Inflammation via the Induction of Heme Oxygenase-1

“…34 It also stimulates ERK phosphorylation in human embryonic kidney cells 35 and epithelial carcinoma cells. 36 In addition, nicotinamide, a major metabolite of niacin, stimulates Erk phosphorylation in human myeloblastic leukemia cells. 37 In the present study, exposure of HCAECs to niacin rapidly phosphorylated p38 MAPK ( Figure 5D) as has been reported for simvastatin, 38 inflammatory cytokines such as interleukin-10, 39 and other stimuli.…”