Enhancement of cue-induced reinstatement of alcohol seeking by acute total sleep restriction in male Wistar rats

Reeves-Darby, Jaren; Berro, Laís F.; Rowlett, James K.; Platt, Donna M.

doi:10.1016/j.pbb.2021.173188

Cited by 6 publications

(4 citation statements)

References 53 publications

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“…Sleep restricted rats showed increased alcohol consumption which was mediated by delta FosB induction [63] and resulted in complex effects on locomotion, rearing, and immobility behaviors [64]. In addition, acute total sleep restriction could enhance cue-induced reinstatement of alcohol seeking in male Wistar rats [65]. Overall, the effects of SDs on various types of abused drugs-mediated behavior are complex and can vary with the type and duration of sleep disruption, type of drugs, animal species, age, and behaviors assessed, with increases, decreases and no changes being reported across studies.…”

Section: Discussionmentioning

confidence: 99%

Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling

et al. 2022

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Sleep disorders have high comorbidity with drug addiction and function as major risk factors for developing drug addiction. Recent studies have indicated that both sleep disturbance (SD) and abused drugs could activate microglia, and that increased neuroinflammation plays a critical role in the pathogenesis of both diseases. Whether microglia are involved in the contribution of chronic SDs to drug addiction has never been explored. In this study, we employed a mouse model of sleep fragmentation (SF) with cocaine treatment and examined their locomotor activities, as well as neuroinflammation levels and dopamine signaling in the striatum, to assess their interaction. We also included mice with, or without, SF that underwent cocaine withdrawal and challenge. Our results showed that SF significantly blunted cocaine-induced locomotor stimulation while having marginal effects on locomotor activity of mice with saline injections. Meanwhile, SF modulated the effects of cocaine on neuroimmune signaling in the striatum and in ex vivo isolated microglia. We did not observe differences in dopamine signaling in the striatum among treatment groups. In mice exposed to cocaine and later withdrawal, SF reduced locomotor sensitivity and also modulated neuroimmune and dopamine signaling in the striatum. Taken together, our results suggested that SF was capable of blunting cocaine-induced psychoactive effects through modulating neuroimmune and dopamine signaling. We hypothesize that SF could affect neuroimmune and dopamine signaling in the brain reward circuitry, which might mediate the linkage between sleep disorders and drug addiction.

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Section: Discussionmentioning

confidence: 99%

Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling

et al. 2022

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“…Sleep disturbances predict relapse ( Brower, 2001 ), and disrupted sleep is a common complaint in people suffering from SUD ( Mahfoud et al, 2009 ). Furthermore, recent preclinical evidence indicates that reduced slow wave sleep enhances cue induced reinstatement of alcohol seeking ( Reeves-Darby et al, 2021 ), indicating that sleep disturbances may be a causal factor in relapse. In addition to the evidence for involvement of sleep disturbances in SUD, a growing number of studies highlight the involvement of the circadian system in this disorder ( McClung et al, 2005 ; Falcon and McClung, 2009 ; Ozburn et al, 2013 ; DePoy et al, 2017 ; Edwards et al, 2018 ; Logan et al, 2018 ; Xue et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder

et al. 2022

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Substance use disorders are a debilitating group of psychiatric disorders with a high degree of comorbidity with major depressive disorder. Sleep and circadian rhythm disturbances are commonly reported in people with substance use disorder and major depression and associated with increased risk of relapse. Hippocampal somatostatin signaling is involved in encoding and consolidation of contextual memories which contribute to relapse in substance use disorder. Somatostatin and clock genes also have been implicated in depression, suggesting that these molecules may represent key converging pathways involved in contextual memory processing in substance use and major depression. We used hippocampal tissue from a cohort of subjects with substance use disorder (n = 20), subjects with major depression (n = 20), subjects with comorbid substance use disorder and major depression (n = 24) and psychiatrically normal control subjects (n = 20) to test the hypothesis that expression of genes involved in somatostatin signaling and clock genes is altered in subjects with substance use disorder. We identified decreased expression of somatostatin in subjects with substance use disorder and in subjects with major depression. We also observed increased somatostatin receptor 2 expression in subjects with substance use disorder with alcohol in the blood at death and decreased expression in subjects with major depression. Expression of the clock genes Arntl, Nr1d1, Per2 and Cry2 was increased in subjects with substance use disorder. Arntl and Nr1d1 expression in comparison was decreased in subjects with major depression. We observed decreased expression of Gsk3β in subjects with substance use disorder. Subjects with comorbid substance use disorder and major depression displayed minimal changes across all outcome measures. Furthermore, we observed a significant increase in history of sleep disturbances in subjects with substance use disorder. Our findings represent the first evidence for altered somatostatin and clock gene expression in the hippocampus of subjects with substance use disorder and subjects with major depression. Altered expression of these molecules may impact memory consolidation and contribute to relapse risk.

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“…In a 12 month observational study by Kolla et al, sleep disturbances (measured by PSQI) were not associated with relapse at 12 months post treatment however, as previousy mentioned, they did suggest an association with relapse when alcohol is used as a hypnotic. Alternatively, in a pre-clinical study in rats published in 2021 exploring the relationship between impaired sleep and alcohol relapse showed that decreased slow-wave sleep and sleep restriction during abstinence from alcohol may place individuals at risk for relapse but this work was conducted in a pre-clinical model and needs to be explored further in individuals with AUD 8 . Furthermore, in a larger prospective study of 80 treatment seeking individuals for AUD, the authors found that individuals with baseline depression, anxiety and sleep difficulties did not predict subsequent alcohol use 9 .…”

Section: Introductionmentioning

confidence: 99%

“…may place individuals at risk for relapse but this work was conducted in a pre-clinical model and needs to be explored further in individuals with AUD 8 . Furthermore, in a larger prospective study of 80 treatment seeking individuals for AUD, the authors found that individuals with baseline depression, anxiety and sleep difficulties did not predict subsequent alcohol use 9 .…”

mentioning

confidence: 99%

A lower sleep regularity index (SRI) is associated with relapse in individuals with alcohol use disorder following inpatient treatment

Barb

Brooks

Kazmi

et al. 2022

Sci Rep

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The sleep regularity index (SRI) is used to measure an individual’s sleep/wake consistency over time. The SRI has been associated with certain health risks; to date, research investigating the relationship between the SRI and relapse in individuals with alcohol use disorder (AUD) is lacking. The aim of this work was to evaluate the SRI and relapse in individuals with AUD following inpatient treatment. Individuals with AUD (n = 77, mean age = 49.5 ± 10.86) were assessed for 28-days following discharge from an inpatient treatment program. Logistic regression was applied to examine the impact of SRI on relapse as the outcome variable of interest. Sleep quality was lower in individuals who relapsed compared to those who did not. Moreover, SRI scores were significantly worse in those who relapsed compared to those who did not. Over the entire patient cohort, lower weekly SRI scores were significantly correlated with longer weekly nap duration. Logistic regression model results indicated that the overall SRI was a significant predictor of relapse. The SRI represents a relevant aspect of sleep health and should be considered when assessing an individual’s sleeping patterns. Behavior based interventions related to the importance of individualized consistency in sleep and wake patterns may be particularly important for treatment seeking individuals with AUD not only during inpatient treatment, but also once these individuals have transitioned into their outpatient phase of recovery. These findings support the notion of SRI as a separate facet of sleep health worth investigating in at-risk, disease specific groups.

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Enhancement of cue-induced reinstatement of alcohol seeking by acute total sleep restriction in male Wistar rats

Cited by 6 publications

References 53 publications

Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling

Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling

Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder

A lower sleep regularity index (SRI) is associated with relapse in individuals with alcohol use disorder following inpatient treatment

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