Enhancement of detection by selective modification of silicon nanobelt field-effect transistors via localized Joule heating

Liu, Hao Heng; Lin, Tzung Han; Sheu, Jeng−Tzong

doi:10.1016/j.snb.2013.10.102

Cited by 9 publications

(16 citation statements)

References 21 publications

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“…1 shows a simple planar device geometry akin to a single-gate MOSFET, a plethora of device geometries have been developed such as nanogap, [22][23][24] nanobelt, 25,26 nanoribbon 18,27-32 and nanowire 15,29,[33][34][35][36][37]38 structures. The application of additional lateral gates has been shown useful in tuning the carrier concentration of the device and pursuit of an optimal gate configuration is an active area of research.…”

Section: Operation Of Field-effect Sensorsmentioning

confidence: 99%

“…26,28,32,36,49,51,107,120,[160][161][162][163][164][165][166] The simplest model for biomolecule-binding reactions, is the first-order Langmuir model of surface-reactions (details in ESI section 10 †). In this model the surface reaction of analyte (A) to the surface sites (S) is treated simply:…”

Section: Surface Binding Reactionsmentioning

confidence: 99%

“…This is particularly problematic for nanoscale dimension devices in which the sensing region of the device can have a small surface area relative to the total exposed surface area. 26 …”

Section: Critical Review Analystmentioning

confidence: 99%

“…8. 26,28,32,37,49,70,107,178,179 The normalised change in current, I norm , is plotted against the device subthreshold slope. The data was obtained from experiments which were not all performed at the same concentration of streptavidin and at more than one ionic strength.…”

Section: Streptavidin Sensing Datamentioning

confidence: 99%

“…Where sufficient data was available, Sensitivity was calculated for the previously presented streptavidin-sensing data 26,28,32,49,70,107 and the results are plotted against subthreshold slope in Fig. 9 and 10.…”

Section: Data Analysis Of Responses In Streptavidin and Ph Sensingmentioning

confidence: 99%

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Field-effect sensors – from pH sensing to biosensing: sensitivity enhancement using streptavidin–biotin as a model system

Lowe

Sun

Zeimpekis

et al. 2017

Analyst

136

107

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a Field-Effect Transistor sensors (FET-sensors) have been receiving increasing attention for biomolecular sensing over the last two decades due to their potential for ultra-high sensitivity sensing, label-free operation, cost reduction and miniaturisation. Whilst the commercial application of FET-sensors in pH sensing has been realised, their commercial application in biomolecular sensing (termed BioFETs) is hindered by poor understanding of how to optimise device design for highly reproducible operation and high sensitivity. In part, these problems stem from the highly interdisciplinary nature of the problems encountered in this field, in which knowledge of biomolecular-binding kinetics, surface chemistry, electrical double layer physics and electrical engineering is required. In this work, a quantitative analysis and critical review has been performed comparing literature FET-sensor data for pH-sensing with data for sensing of biomolecular streptavidin binding to surface-bound biotin systems. The aim is to provide the first systematic, quantitative comparison of BioFET results for a single biomolecular analyte, specifically streptavidin, which is the most commonly used model protein in biosensing experiments, and often used as an initial proofof-concept for new biosensor designs. This novel quantitative and comparative analysis of the surface potential behaviour of a range of devices demonstrated a strong contrast between the trends observed in pH-sensing and those in biomolecule-sensing. Potential explanations are discussed in detail and surfacechemistry optimisation is shown to be a vital component in sensitivity-enhancement. Factors which can influence the response, yet which have not always been fully appreciated, are explored and practical suggestions are provided on how to improve experimental design.

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Section: Operation Of Field-effect Sensorsmentioning

confidence: 99%

Section: Surface Binding Reactionsmentioning

confidence: 99%

“…This is particularly problematic for nanoscale dimension devices in which the sensing region of the device can have a small surface area relative to the total exposed surface area. 26 …”

Section: Critical Review Analystmentioning

confidence: 99%