Enhancement of energy production by black ginger extract containing polymethoxy flavonoids in myocytes through improving glucose, lactic acid and lipid metabolism

Toda, Kazuya; Takeda, Shogo; Hitoe, Shoketsu; Nakamura, Seikou; Matsuda, Hisashi; Shimoda, Hiroshi

doi:10.1007/s11418-015-0948-y

Cited by 38 publications

(31 citation statements)

References 35 publications

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“…KPE was suggested to improve these decreases. We previously confirmed that PMFs, particularly 5,7-dimethoxyflavone in KPE, improved metabolism in muscle cells by activating AMPK [24]. AMPK is known to play a critical role in the regulation of energy homeostasis and is related to physical fitness, endurance, and fatigue [41][42][43][44][45][46][47][48].…”

Section: Discussionmentioning

confidence: 87%

“…anti-inflammatory, antioxidant [18][19][20][21], anticancer [22,23], muscular metabolismenhancing [24], anti-photoaging [25], phosphodiesterase (PDE)5 inhibitory [26], anti-cardiovascular disease [27], and viral protease inhibitory [28] activities). A large number of studies have investigated the bioactivities of black ginger extract (KPE), which is rich in PMFs [24,[29][30][31][32][33][34][35][36][37]. We also reported that PMFs in KPE improved muscular metabolism through AMP-activated protein kinase (AMPK) activation in myocytes [24].…”

Section: Backgroundsmentioning

confidence: 99%

“…A large number of studies have investigated the bioactivities of black ginger extract (KPE), which is rich in PMFs [24,[29][30][31][32][33][34][35][36][37]. We also reported that PMFs in KPE improved muscular metabolism through AMP-activated protein kinase (AMPK) activation in myocytes [24]. Furthermore, clinical trials have been conducted on the effects of KPE physical performance in athletes and elderly subjects [36,37].…”

Section: Backgroundsmentioning

confidence: 99%

“…KPE was prepared according to our previously reported method [24]. KPE was obtained from the dried rhizomes of black ginger by extracting with aqueous ethanol (yield 15.9%).…”

Section: Test Samplesmentioning

confidence: 99%

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Enhancement of physical fitness by black ginger extract rich in polymethoxyflavones: a double-blind randomized crossover trial

Toda¹

2016

Integr Mol Med

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Section: Discussionmentioning

confidence: 87%

Section: Backgroundsmentioning

confidence: 99%

Section: Backgroundsmentioning

confidence: 99%

“…KPE was prepared according to our previously reported method [24]. KPE was obtained from the dried rhizomes of black ginger by extracting with aqueous ethanol (yield 15.9%).…”

Section: Test Samplesmentioning

confidence: 99%

See 2 more Smart Citations

Enhancement of physical fitness by black ginger extract rich in polymethoxyflavones: a double-blind randomized crossover trial

Toda¹

2016

Integr Mol Med

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“…Thus, the existence of the whole organism to a certain extent depends on the functional activity of small intestine. Recently, for the correction of metabolic disorders in humans often use herbal remedies that are gentle action and mild side effects on the background of a broad therapeutic range [1][2][3][4][5][6]. The natural complex of biologically active substances -milk thistle -more than 2 thousand years uses to treat a range of diseases -from inflammation and arthritis to prostate carcinoma and breast cancer [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Effect of Total Extract of Milk Thistle Fruits on the Absorption of Glycine in the Rats Small Intestine under Physiological Conditions

Ov¹

2015

J Hepatol Gastroint Dis

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Objectives and method: To determine the effect of total extract of milk thistle fruits on the velocity of glycine absorption in the chronic experiments under physiological condition with no operation trauma, pain, narcosis and atrophy of the small intestine. Results:In the presence of total extract of milk thistle fruits the glycine absorption velocity increases during one hour of perfusion. Absolute values of glycine absorption are higher in the presence of milk thistle fruits extract then in its absence. We observed no dissolution of perfusate with gastrointestinal fluids in the small intestine functioning part indicating that absorption of water in this fragment of small intestine prevails in the presence and in the absence of milk thistle extract both. Conclusions:Total extract of milk thistle fruits activates the velocity of absorption of glycine in the functioning fragment of the rats′ small intestine under physiological conditions.

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5‐Hydroxy‐7‐methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy

Ono

Yoshida

Maekawa

et al. 2018

Food Science & Nutrition

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Skeletal muscle plays a critical role in locomotion and energy metabolism. Maintenance or enhancement of skeletal muscle mass contributes to the improvement of mobility and prevents the development of metabolic diseases. The extracts from Kaempferia parviflora rhizomes contain at least ten methoxyflavone derivatives that exhibit enhancing effects on ATP production and glucose uptake in skeletal muscle cells. In the present study, we investigated the effects of ten K. parviflora‐derived methoxyflavone derivatives (six 5,7‐dimethoxyflavone (DMF) derivatives and four 5‐hydroxy‐7‐methoxyflavone (HMF) derivatives) on skeletal muscle hypertrophy. Murine C2C12 myotubes and senescence‐accelerated mouse‐prone 1 (SAMP1) mice treated with methoxyflavones were used as experimental models to determine the effects of HMF derivatives on myotube diameter and size and muscle mass. The four HMF derivatives, but not the six DMF derivatives, increased myotube diameter. The 5‐hydroxyflavone, 7‐methoxyflavone, and 5,7‐dihydroxyflavone had no influence on myotube size, a result that differed from HMF. Dietary administration of the mixture composed of the four HMF derivatives resulted in increase in the soleus muscle size and mass in SAMP1 mice. HMF derivatives also promoted protein synthesis in myotubes, and treatment with the intracellular Ca2+ chelator BAPTA‐AM, which depletes intracellular Ca2+ levels, inhibited this promotion. Furthermore, BAPTA‐AM inhibited HMF‐promoted protein synthesis even when myotubes were incubated in Ca2+‐free medium. These results indicate that HMF derivatives induce myotube hypertrophy and that both the 5‐hydroxyl group and the 7‐methoxy group in the flavones are necessary for myotube hypertrophy. Furthermore, these results suggest that HMF‐induced protein synthesis requires intracellular Ca2+, but not extracellular Ca2+.

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Enhancement of energy production by black ginger extract containing polymethoxy flavonoids in myocytes through improving glucose, lactic acid and lipid metabolism

Cited by 38 publications

References 35 publications

Enhancement of physical fitness by black ginger extract rich in polymethoxyflavones: a double-blind randomized crossover trial

Enhancement of physical fitness by black ginger extract rich in polymethoxyflavones: a double-blind randomized crossover trial

Effect of Total Extract of Milk Thistle Fruits on the Absorption of Glycine in the Rats Small Intestine under Physiological Conditions

5‐Hydroxy‐7‐methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy

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