Enhancement of Fluid Mixing with U-Shaped Channels on a Rotating Disc

Hsu, Chi-Wei; Shih, Po-Tin; Chen, Jerry M.

doi:10.3390/mi11121110

Cited by 10 publications

(6 citation statements)

References 47 publications

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“…In the experiment, the quantification of mixing performance uses concentrations measured in the imaging area of the spiral channel exit section. The mixing efficiency calculation utilizes the pixel intensities of the average RGB values within the imaging area where 100% indicates that the two liquids are completely mixed.…”

Section: Methodology and Feasibility Validationmentioning

confidence: 99%

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Micromixer with Fine-Tuned Mathematical Spiral Structures

et al. 2021

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Micromixers with the microchannel structure can enable rapid and efficient mixing of multiple types of fluids on a microfluidic chip. Herein, we report the mixing performance of three passive micromixers based on the different mathematical spiral structures. We study the fluid flow characteristics of Archimedes spiral, Fermat spiral, and hyperbolic spiral structures with various channel widths and Reynolds number (Re) ranging from 0 to 10 via numerical simulation and visualization experiments. In addition, we analyze the mechanism of streamlines and Dean vortices at different cross sections during fluid flows. As the fluid flows in the Fermat spiral channel, the centrifugal force induces the Dean vortex to form a chaotic advection, enhancing the fluid mixing performance. By integrating the Fermat spiral channel into a microfluidic chip, we successfully detect acute myocardial infarction (AMI) marker with the double-antibody sandwich method and reduce the detection time to 10 min. This method has a low reagent consumption and a high reaction efficiency and demonstrates great potential in point-of-care testing (POCT).

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Section: Methodology and Feasibility Validationmentioning

confidence: 99%

“…The mixing efficiency calculation utilizes the pixel intensities of the average RGB values within the imaging area. 53…”

Section: Methodology and Feasibility Validationmentioning

confidence: 99%

Micromixer with Fine-Tuned Mathematical Spiral Structures

et al. 2021

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“…Centrifugal microfluidics offers a variety of methods to introduce vortical flow and chaotic eddies in order to increase the speed of mixing 9 . For fluids moving through channels, recent developments include variations on obstructions in the channel 10 , 11 , cross-flow systems 12 , 13 , side-chambers on the channel 14 , and variations in channel shape and cross-section 15 – 20 .…”

Section: Introductionmentioning

confidence: 99%

Lab on a bead with oscillatory centrifugal microfluidics for fast and complete mixing enables fast and accurate biomedical assays

Williams,

Li,

Chandrasekhar

et al. 2024

Sci Rep

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Rapid mixing and precise timing are key for accurate biomedical assay measurement, particularly when the result is determined as the rate of a reaction: for example rapid immunoassay in which the amount of captured target is kinetically determined; determination of the concentration of an enzyme or enzyme substrate; or as the final stage in any procedure that involves a capture reagent when an enzyme reaction is used as the indicator. Rapid mixing and precise timing are however difficult to achieve in point-of-care devices designed for small sample volumes and fast time to result. By using centrifugal microfluidics and transposing the reaction surface from a chamber to a single mm-scale bead we demonstrate an elegant and easily manufacturable solution. Reagents (which may be, for example, an enzyme, enzyme substrate, antibody or antigen) are immobilised on the surface of a single small bead (typically 1–2 mm in diameter) contained in a cylindrical reaction chamber subjected to periodically changing rotational accelerations which promote both mixing and uniform mass-transfer to the bead surface. The gradient of Euler force across the chamber resulting from rotational acceleration of the disc, dΩdisc/dt, drives circulation of fluid in the chamber. Oscillation of Euler force by oscillation of rotational acceleration with period, T, less than that of the hydrodynamic relaxation time of the fluid, folds the fluid streamlines. Movement of the bead in response to the fluid and the changing rotational acceleration provides a dynamically changing chamber shape, further folding and expanding the fluid. Bead rotation and translation driven by fluid flow and disc motion give uniformity of reaction over the surface. Critical parameters for mixing and reaction uniformity are the ratio of chamber radius to bead radius, rchamber/rbead, and the product Trchamber(dΩdisc/dt), of oscillation period and Euler force gradient across the fluid. We illustrate application of the concept using the reaction of horse radish peroxidase (HRP) immobilised on the bead surface with its substrate tetramethylbenzidine (TMB) in solution. Acceleration from rest to break a hydrophobic valve provided precise timing for TMB contact with the bead. Solution uniformity from reaction on the surface of the bead in volumes 20–50 uL was obtained in times of 2.5 s or less. Accurate measurement of the amount of surface-bound HRP by model fitting to the measured kinetics of colour development at 10 s intervals is demonstrated.

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“…The current special issue includes 12 research papers [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. The topics of the papers are focused on design of micromixers [ 2 , 3 , 4 , 5 , 6 , 7 , 9 , 12 , 13 ], fabrication [ 8 , 9 , 12 ], and analysis [ 11 ]. Some of them propose novel micromixer designs [ 2 , 3 , 5 , 6 ], which include a slight modification of an existing micromixer [ 6 ].…”

mentioning

confidence: 99%

“…Most of the works used only computational fluid dynamics (CFD) for the analysis [ 2 , 3 , 4 , 5 , 6 , 10 , 13 ]. However, some of the works employed experimental analysis [ 8 , 9 ] or both experimental and CFD analyses [ 7 , 12 ]. On the other hand, Kim et al [ 11 ] performed a theoretical analysis of an electromagnetic micromixer and compared the results with experimental measurements.…”

mentioning

confidence: 99%