Enhancement of Glucose Toxicity by Hyperbaric Oxygen Exposure in Diabetic Rats

Matsunami, Tokio; Sato, Yukita; Morishima, Tsunenori; Mano, Yoshihiro; Yukawa, Masayoshi

doi:10.1620/tjem.216.127

Cited by 10 publications

(8 citation statements)

References 16 publications

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“…In contrary to our findings, Matsunami et al. () reported increased blood glucose levels in a similar animal model of experimental type 1 diabetes, and they found a reduction in the insulin‐producing β ‐cells in diabetic rats receiving HBO therapy compared with a control group. These differences might be attributed to different levels of diabetes.…”

Section: Discussioncontrasting

confidence: 99%

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Hyperbaric oxygen therapy reduces renal lactate production

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Nielsen

et al. 2017

Physiological Reports

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Intrarenal hypoxia is an acknowledged factor contributing to the development of diabetic nephropathy. Hyperbaric oxygen (HBO) therapy is a well‐known adjuvant treatment for several medical conditions, such as decompression sickness, infections, and wound healing. The underlying metabolic response of HBO is largely unknown. In this study, we investigated the effect of HBO on the intrarenal metabolic alteration in diabetes. Hyperpolarized [1‐13C]pyruvate MRI was performed to assess intrarenal energy metabolism in normoglycemic controls and short‐term (2 weeks) streptozotocin‐induced diabetic rats with and without HBO for five consecutive days. HBO therapy blunted intrarenal lactate production, 3 days after the therapy, in both normoglycemic controls and diabetic rats without affecting either lactate dehydrogenase mRNA expression or activity. HBO therapy reduced lactate formation in both normoglycemic and hyperglycemic rats. These findings support hyperpolarized [1‐13C]pyruvate MRI as a novel method for monitoring HBO therapy via the pyruvate to lactate conversion.

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Section: Discussioncontrasting

confidence: 99%

“…The above‐mentioned studies (Matsunami et al. ; Eynan et al. ) used a very short time interval between HBO therapy and the subsequent examination of its effects.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen therapy reduces renal lactate production

Nørlinger

Nielsen

et al. 2017

Physiological Reports

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“…81 In addition, HBO therapy may have beneficial effects on atherosclerosis and glycemic control, 82,83 even though the evidence from animal studies is rather contradictory. 84,85…”

Section: Poisoningmentioning

confidence: 99%

The Role of Hyperbaric Oxygen in the Treatment of Diabetic Foot Ulcers

et al. 2011

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Diabetic foot ulcers are still extremely difficult to heal. Therefore, therapeutic options to improve healing rates are continuously being explored. Hyperbaric oxygen (HBO) has been used in addition to standard treatment of the diabetic foot for more than 20 years. Evidence suggests that HBO reduces amputation rates and increases the likelihood of healing in infected diabetic foot ulcers, in association with improved tissue oxygenation, resulting in better quality of life. Nonetheless, HBO represents an expensive modality, which is only available in few centers. Moreover, adverse events necessitate a closer investigation of its safety. Finally, it is not entirely clear which patients stand to benefit from HBO and how these should be selected. In conclusion, HBO appears promising, but more experience is needed before its broad implementation in the routine care of the diabetic foot.

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“…In animal experiments, HBO treatment prevented an increase in blood glucose level during growth and changed the muscle type to slow twitch subtype (13)(14)(15). On the other hand, HBO treatment significantly increased blood glucose levels in type 1 diabetic rats compared with the levels in non-diabetic controls (16). However, there has been no investigation of the effects of HBO on lipid metabolism except for decreased oxidized low-density lipoprotein (17).…”

Section: Introductionmentioning

confidence: 99%