Enhancement of Healthy Personality Through Psychiatric Medication: The Influence of SSRIs on Neuroticism and Extraversion

Ilieva, Iliana

doi:10.1007/s12152-014-9226-z

Cited by 25 publications

(23 citation statements)

References 62 publications

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“…Moreover, patients with high neuroticism may benefit from therapies which have been shown to reduce neuroticism and increase extraversion. This has been demonstrated in patients with depression using cognitive-behavioral therapy, treatment with selective serotonin-reuptake inhibitors (SSRIs), and repetitive transcranial magnetic stimulation (rTMS) (Berlim et al, 2013; Ilieva, 2015; Tang et al, 2009). Similarly, the negative affect and maladaptive response to stress experienced by patients with schizophrenia and high neuroticism may be good targets for treatment with metacognitive and insight therapies (REFs) (Dimaggio and Lysaker, 2015; Hillis et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Personality traits predicting quality of life and overall functioning in schizophrenia

Ridgewell

Blackford

McHugo

2017

Schizophrenia Research

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Introduction Clinical symptoms and sociodemographic variables predict level of functioning and quality of life in patients with schizophrenia. However, few studies have examined the effect of personality traits on quality of life and overall functioning in schizophrenia. Personality traits are premorbid to illness and may predict the way patients experience schizophrenia. The aim of this study was to examine the individual and additive effects of two core personality traits—neuroticism and extraversion—on quality of life and functioning. Methods Patients with schizophrenia-spectrum disorders (n = 153) and healthy controls (n = 125) completed personality and quality of life questionnaires. Global functioning was assessed during a clinician-administered structured interview. Neuroticism and extraversion scores were analyzed both as continuous variables and as categorical extremes (High versus Normal Neuroticism, Low versus Normal Extraversion). Results Quality of life was significantly associated with neuroticism, extraversion, and the neuroticism × diagnosis and extraversion × diagnosis interactions. For patients, a lower neuroticism score (in the normal range) was associated with quality of life scores comparable to controls; whereas high neuroticism scores in patients were associated with the lowest quality of life. For overall functioning, only diagnosis had a significant effect. Conclusion Neuroticism modulates quality of life and may provide an important key to improving the life of patients with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Personality traits predicting quality of life and overall functioning in schizophrenia

Ridgewell

Blackford

McHugo

2017

Schizophrenia Research

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“…Use of psychotropic drugs (e.g. antidepressants or psychedelics) has also been found to be associated with long‐term changes in personality (Erritzoe et al, 2018; Ilieva, 2015).…”

Section: Longitudinal Experience‐wide Association Studiesmentioning

confidence: 99%

Longitudinal Experience–Wide Association Studies—A Framework for Studying Personality Change

et al. 2020

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The importance of personality for predicting life outcomes in the domains of love, work, and health is well established, as is evidence that personality traits, while relatively stable, can change. However, little is known about the sources and processes that drive changes in personality traits and how such changes might impact important life outcomes. In this paper, we make the case that the research paradigms and methodological approaches commonly used in personality psychology need to be revised to advance our understanding of the sources and processes of personality change. We propose Longitudinal Experience‐Wide Association Studies as a framework for studying personality change that can address the limitations of current methods, and we discuss strategies for overcoming some of the challenges associated with Longitudinal Experience‐Wide Association Studies. © 2020 European Association of Personality Psychology

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“…"Empirical data are accumulating to suggest that SSRIs, when used non-clinically, can affect some facets of Neuroticism, with most consistent support for a specific medication-related reduction of Angry Hostility." 31 On the contrary, sufficient evidence is lacking to substantiate the SSRI-driven change in other Neuroticism facets, such as Impulsiveness-and in Extraversion facets such as Warmth, Gregariousness, or Assertiveness. "Future data are needed to corroborate and extend the existing findings, as well as to determine whether, in non-clinical samples, reliable effects emerge globally at the trait-level, or whether they are confined to specific facets."…”

Section: -6 a Roasei Perspective On Usage Of Prescription Drugs Formentioning

confidence: 99%

Reorientation of Activities and Self-environment Integration (ROASEI): Further development and comparison with trait personality theories

Agarwal¹

2020

Preprint

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Reorientation of activities and self-environment integration (ROASEI) is a novel theory of activities. This theory has been developed further, mainly by comparing it with the theories of personality. The ROASEI has parallels with Big-Two and Biggest-One of Five-Factor framework. ROASEI has also been compared with reversal theory. Finally, personality “enhancement” with prescription drugs has been analyzed in the perspective of ROASEI.

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Enhancement of Healthy Personality Through Psychiatric Medication: The Influence of SSRIs on Neuroticism and Extraversion

Cited by 25 publications

References 62 publications

Personality traits predicting quality of life and overall functioning in schizophrenia

Personality traits predicting quality of life and overall functioning in schizophrenia

Longitudinal Experience–Wide Association Studies—A Framework for Studying Personality Change

Reorientation of Activities and Self-environment Integration (ROASEI): Further development and comparison with trait personality theories

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