In this paper, the investigation of pool boiling heat transfer on biphilic micro/nanostructured surfaces is presented. An array of micrococoons from silicon oxide nanowires was synthesized on the surface of a copper heater using the gas-jet electron beam plasma chemical vapor deposition method. The biphilic properties of the surface were achieved by applying fluoropolymer spots by hot wire chemical vapor deposition. Technology of creating biphilic surfaces was developed and boiling curves were obtained for used samples. The advantages of using a biphilic surface to enhance heat transfer were demonstrated in comparison with a smooth surface and a micro-nanostructured surface without local hydrophobic fluoropolymer regions. This technology can be applied to enhance boiling heat transfer.