Enhancement of HIV-1 Tat fusion protein transduction efficiency by bog blueberry anthocyanins

Lee, Sun-Hwa; Jeong, Hoon-Jae; Kim, Dae‐Won; Sohn, Eun-Jeong; Kim, Mi Jin; Kim, Duk‐Soo; Kang, Tae‐Cheon; Lim, Sabina; Kang, Il‐Jun; Cho, Sung‐Woo; Lee, Kil-Soo; Park, Jin-Seu; Eum, Won-Sik; Choi, Soo‐Young

doi:10.3858/bmbrep.2010.43.8.561

Cited by 1 publication

(1 citation statement)

References 36 publications

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“…Therefore, various ways of improving the delivery of therapeutic molecules have been extensively studied [3,22,26,27]. We have also kept searching for molecules to improve the transduction efficiency and therapeutic utilization of many protein transduction domain (PTD) fusion proteins, and recently reported that some molecules such as bog blueberry anthocyanins (BBA) and pergolide mesylate enhance the transduction efficiency of PTD fusion proteins into cells or tissues, leading to improvement of the therapeutic activities of PTD fusion proteins [15,23].…”

Section: Effect Of Sf Peptide On In Vitro and In Vivo Transduction Efmentioning

confidence: 99%

Enhancement of Anti-Inflammatory Activity of PEP-1-FK506 Binding Protein by Silk Fibroin Peptide

Kim

Hwang²,

Kim³

et al. 2012

J. Microbiol. Biotechnol.

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Silk fibroin (SF) peptide has been traditionally used as a treatment for flatulence, spasms, and phlegm. In this study, we examined whether SF peptide enhanced the antiinflammatory effect of PEP-1-FK506 binding protein (PEP-1-FK506BP) through comparing the anti-inflammatory activities of SF peptide and/or PEP-1-FK506BP. In the presence or absence of SF peptide, transduction levels of PEP-1-FK506BP into HaCaT cells and mice skin and anti-inflammatory activities of PEP-1-FK506BP were identified by Western blot and histological analyses. SF peptide alone effectively reduced both mice ear edema and the elevated levels of cyclooxygenase-2, interleukin-6 and-1β, and tumor necrosis factor-α, showing similar anti-inflammatory effect to that of PEP-1-FK506BP. Furthermore, co-treatment with SF peptide and PEP-1-FK506BP exhibited more enhanced anti-inflammatory effects than the samples treated with SF peptides or PEP-1-FK506BP alone, suggesting the possibility that SF peptide and PEP-1-FK506BP might interact with each other. Moreover, the transduction data demonstrated that SF peptide did not affect the transduction of PEP-1-FK506BP into HaCaT cells and mice skin, indicating that the improvement of anti-inflammatory effect of PEP-1-FK506BP was not caused by enhanced transduction of PEP-1-FK506BP. Thus, these results suggest the possibility that co-treatment with SF peptide and PEP-1-FK506BP may be exploited as a useful therapy for various inflammationrelated diseases.

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Section: Effect Of Sf Peptide On In Vitro and In Vivo Transduction Efmentioning

confidence: 99%

Enhancement of Anti-Inflammatory Activity of PEP-1-FK506 Binding Protein by Silk Fibroin Peptide

Kim

Hwang²,

Kim³

et al. 2012

J. Microbiol. Biotechnol.

View full text Add to dashboard Cite

show abstract

Enhancement of HIV-1 Tat fusion protein transduction efficiency by bog blueberry anthocyanins

Abstract: Though protein transduction domains (PTDs

Cited by 1 publication

References 36 publications

Enhancement of Anti-Inflammatory Activity of PEP-1-FK506 Binding Protein by Silk Fibroin Peptide

Enhancement of Anti-Inflammatory Activity of PEP-1-FK506 Binding Protein by Silk Fibroin Peptide

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