Enhancement of hydrophilicity, biocompatibility and biodegradability of poly(ε-caprolactone) electrospun nanofiber scaffolds using poly(ethylene glycol) and poly(L-lactide-co-ε-caprolactone-co-glycolide) as additives for soft tissue engineering

Arbade, Gajanan Kashinathrao; Srivastava, J.P.; Tripathi, Vidisha; Lenka, Nibedita; Patro, T. Umasankar

doi:10.1080/09205063.2020.1769799

Cited by 38 publications

(26 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All of these polymers are biodegradable, biocompatible, easily processable, and have appropriate mechanical properties. It is easy to control their physical and mechanical properties by tuning the polymeric solution’s concentration, using appropriate solvents and parameters of the process [ 7 ]. One of the most favorable properties of electrospun nanofibers is their morphology.…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering

2020

View full text Add to dashboard Cite

Electrospun polymer nanofibers have received much attention in tissue engineering due to their valuable properties such as biocompatibility, biodegradation ability, appropriate mechanical properties, and, most importantly, fibrous structure, which resembles the morphology of extracellular matrix (ECM) proteins. However, they are usually hydrophobic and suffer from a lack of bioactive molecules, which provide good cell adhesion to the scaffold surface. Post-electrospinning surface functionalization allows overcoming these limitations through polar groups covalent incorporation to the fibers surface, with subsequent functionalization with biologically active molecules or direct deposition of the biomolecule solution. Hydrophilic surface functionalization methods are classified into chemical approaches, including wet chemical functionalization and covalent grafting, a physiochemical approach with the use of a plasma treatment, and a physical approach that might be divided into physical adsorption and layer-by-layer assembly. This review discusses the state-of-the-art of hydrophilic surface functionalization strategies of electrospun nanofibers for tissue engineering applications. We highlighted the major advantages and drawbacks of each method, at the same time, pointing out future perspectives and solutions in the hydrophilic functionalization strategies.

show abstract

Section: Introductionmentioning

confidence: 99%

Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering

2020

View full text Add to dashboard Cite

show abstract

“…The polymer presents mechanical properties compatible to diverse applications, being the most highlighted ones it's low melting temperature, non-toxic nature, flexibility and softness (Fox et al, 2020). Furthermore, it can be easily processed by any polymer fabrication technology (Arbade et al, 2020).…”

Section: Filter Mesh 3d Printingmentioning

confidence: 99%

Individual protection mask with improved filtering properties: 3D printed solution guided by design materials selection

Pagnan

Ayres³

et al. 2020

SDRJ

View full text Add to dashboard Cite

The COVID-19 pandemic has mobilized most countries to investigate multiple virus mitigation interventions, the face protection masks are among the main ones. Filtration and breathability are important factors in the applied materials choice. Design plays a fundamental innovative role in developing new products and materials that meet this emergency demand. 3D printing allows adjustments from an industrial production to answer an increasingly specific demand. This process allows the printing of a poly (lactic acid) (PLA) filter mesh with Tourmaline (TM) for a mask made in a triple layer with cotton fabric. One of the properties of TM is the negative ions emission, which allows capturing particles dispersed in the air. PLA is a bio-based and biodegradable polymer, with the corn as it’s most effective source. It makes it a good choice for the project, aiming to be aligned to environmental issues. In addition, the cotton application and the modeling directed to the domestic sewing use make the project accessible to the population, adaptied to digital and personal manufacturing and aligned to the Maker Movement.

show abstract

“…Accordingly, it is evident that in the field of biomedical application, a hydrophilic polymer (natural or synthetic origin) with biocompatible properties is considered to be more favorable to interact with cells. [ 22–24 ] Hence, blending the PLA and PCL with the hydrophilic polymers of either natural and synthetic origin offers enhanced hydrophilicity of those polymers without being modified chemically. Consequently, a wide variety of blends in the combination of PCL and PLA with hydrophilic polymers were explored for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Manipulating hydrophobicity of polyester nanofiber mats with egg albumin to enhance cell interactions

Patel

Pandey

Killi

et al. 2021

Polymer Engineering & Sci

View full text Add to dashboard Cite

A hybrid of poly‐l‐lactic acid (PLA) and poly‐ε‐caprolactone (PCL) system was designed using hydrophilic generally regarded as safe (GRAS) protein, egg albumin (EA), and fabricated as nanofiber mats (NM) to facilitate improved cell interactions and functionality. Our studies include, preparation and analysis of physicochemical properties of NM. Surface morphology of NM was smooth with the diameter ranging from 250 to 400 nm. The contact angle of NM decreased from 80 to 45° with the increase in EA concentration. The rate and extent of swelling was increased 3‐folds with the addition of EA. Release studies of NM showed maximum amount of MTz was released with the increase in MTz concentration (>85%). The MTz interaction with EA and structure stability of EA was confirmed from fluorescence and circular dichroism studies. NM showed increase in inhibition of bacterial growth of Staphylococcus aureus and Escherichia coli with the increase in MTz concentration. Cell viability of the NM was >80% and also, the cell proliferation increased as EA content increased. NM hemolytic activity was less than 5% suggesting compatibility. Hence, results concluded that EA had regulated hydrophobicity, promoted cell interactions, and proliferation and therefore, NM is considered safe for tissue regeneration.

show abstract

Enhancement of hydrophilicity, biocompatibility and biodegradability of poly(ε-caprolactone) electrospun nanofiber scaffolds using poly(ethylene glycol) and poly(L-lactide-co-ε-caprolactone-co-glycolide) as additives for soft tissue engineering

Cited by 38 publications

References 83 publications

Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering

Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering

Individual protection mask with improved filtering properties: 3D printed solution guided by design materials selection

Manipulating hydrophobicity of polyester nanofiber mats with egg albumin to enhance cell interactions

Contact Info

Product

Resources

About