Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon.

Ida, Shiroh; Hooks, John J.; Siraganian, R P; Notkins, Abner Louis

doi:10.1084/jem.145.4.892

Cited by 239 publications

(91 citation statements)

References 26 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, Hooks et al (16) have found elevated levels of interferon in the sera of patients with severe systemic lupus erythematosis, and suggested the possibility that this interferon may play a pathogenetic role. Ida and co-workers (17) have suggested that the interferon produced in the course of respiratory infections may be responsible for some of the "allergic" manifestations. If we may extrapolate the results of our study and the extensive studies of De Maeyer et al (9)(10)(11), it seems possible that there is a genetic control for the production of interferon to different viruses in man.…”

Section: Discussionmentioning

confidence: 99%

Severity of lymphocytic choriomeningitis virus disease in different strains of suckling mice correlates with increasing amounts of endogenous interferon.

Rivière¹,

Gresser²,

Guillon³

et al. 1980

The Journal of Experimental Medicine

View full text Add to dashboard Cite

A marked difference was observed in the severity of disease in lymphocytic choriomeningitis (LCM) virus-infected suckling BALB/c, Swiss, and C3H mice. BALB/c mice had minimal liver lesions and none died, whereas C3H mice had extensive liver lesions and all mice died. An intermediate pattern was oberved for Swiss mice (36% mortality). Although there was no difference in the titers of LCM virus in the plasma or liver between these three strains of mice, there was a marked difference in the amount of interferon produced and the duration of interferonemia. C3H mice produced more interferon than Swiss mice which produced more interferon than BALB/c mice, indicating a direct correlation between the amount of interferon induced by LCM virus and the extent of disease. Inoculation of a potent anti-mouse interferon globulin markedly reduced the incidence of mortality in virus-infected C3H mice. BALB/c mice were as sensitive to the effects of interferon as C3H mice because daily administration of potent interferon preparations did induce disease in this strain. This ensemble of results supports our contention that endogenous interferon is in large part responsible for the manifestaions of acute LCM virus disease in suckling mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Severity of lymphocytic choriomeningitis virus disease in different strains of suckling mice correlates with increasing amounts of endogenous interferon.

Rivière¹,

Gresser²,

Guillon³

et al. 1980

The Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…It seems possible that interferon may also influence other metabolic processes such as energy utilization. In view of these considerations, it is not surprising that interferon can either inhibit or enhance certain cell functions (9)(10)(11)(12)(13)(14)(15)(16)(35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to interferon's well-known antiviral action, preparations of it have been reported to exert multiple effects on cells [i.e., inhibition of the multiplication of bormal and tumor cells in culture (2)(3)(4)(5), inhibition of the growth of a variety of transplantable tumors in mice (6)(7)(8), modulation of the synthesis and release of specific cellular products (9)(10)(11)(12)(13)(14)(15)(16), modification of the cell surface (17)(18)(19)(20)(21), and modulation of both the humoral (22)(23)(24)(25)(26)(27) and cell-mediated immune responses (28)(29)(30)(31)(32)(33)(34)]. Although experimental results support the hypothesis that the antiviral action of interferon is only one manifestation of its effect on cells (35)(36)(37), it is important to emphasize that these experiments were undertaken using preparations in which interferon protein constituted at most only 1% of the total protein content.…”

mentioning

confidence: 99%

Electrophoretically pure mouse interferon exerts multiple biologic effects.

Gresser¹,

Maeyer‐Guignard²,

Tovey³

et al. 1979

Proc. Natl. Acad. Sci. U.S.A.

101

View full text Add to dashboard Cite

Electrophoretically pure mouse interferon was examined for a number of biologic effects previously ascribed to crude or partially purified interferon preparations. These effects include: inhibition of the growth of a transplantable tumor in mice; inhibition of cell multiplication of mouse tumor cells in vitro; enhancement of the expression of histocompatibility antigens on mouse tumor cells in vitro; inhibition of antibody formation in vitro; inhibition of sensitization to sheep erythrocytes and the expression of delayed type hypersensitivity in mice; enhancement of natural killer cell activity in vivo and in vitro; enhancement of cell sensitivity to the toxicity of poly(I)poly(C); and enhanced production ("priming") of interferon production in vitro. Our results establish that the molecules responsible for the antiviral action of interferon are also responsible for these varied biologic effects.In many animal cells, viral infection results in the production of potent antiviral glycoproteins called interferon (1). In addition to interferon's well-known antiviral action, preparations of it have been reported to exert multiple effects on cells [i.e., inhibition of the multiplication of bormal and tumor cells in culture (2-5), inhibition of the growth of a variety of transplantable tumors in mice (6-8), modulation of the synthesis and release of specific cellular products (9-16), modification of the cell surface (17-21), and modulation of both the humoral (22-27) and cell-mediated immune responses (28-34)]. Although experimental results support the hypothesis that the antiviral action of interferon is only one manifestation of its effect on cells (35-37), it is important to emphasize that these experiments were undertaken using preparations in which interferon protein constituted at most only 1% of the total protein content. We have recently succeeded in preparing electrophoretically pure (EP) mouse interferon (38), and we present herein results which show that a number of the biologic effects previously observed with crude or partially purified preparations are also observed with this EP interferon. These results provide the most direct evidence to date that interferon not only inhibits viral multiplication but also exerts a variety of important biologic effects on cells. MATERIALS AND METHODSPartially purified mouse interferon Mouse C-243 cell interferon was prepared, assayed, partially purified, and concentrated as described (39). The specific activity of the individual preparations ranged from 1 X 107 to 2.9 X 107 mouse interferon reference units/mg of protein. Electrophoretically pure (EP) mouse interferonMouse C-243 cell interferon was prepared as above but was kept for at least 2 weeks at pH 2 before purification. (It was not concentrated by precipitation with ammonium sulfate.) Purification was achieved by two-step affinity chromatography, first on a poly(U)-agarose column (40) and then on a column of sheep anti-mouse interferon globulin coupled to Affigel (38,41).We may summarize the criteria o...

show abstract

“…Frick et al (1979) determined that viruses could initiate immunological pathways to induce allergic sensitizations to viruses and pollens in children, probably by altering populations of T and B lymphocytes. Additionally, Ida et al (1977) found an enhancement of IgE-mediated histamine release from human basophils by viruses, in conjunction with interferon.…”

mentioning

confidence: 99%