Enhancement of leukocyte functions in aged mice supplemented with the antioxidant thioproline

Fuente, Mónica De la; Ferrández, M.D.; Rı́o, M. Del; Burgos, Marı́a Sol; Miquel, Jaime

doi:10.1016/s0047-6374(98)00071-2

Cited by 43 publications

(27 citation statements)

References 27 publications

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“…However, it is not known whether these effects of vitamin E are attributable to its antioxidant or some other function. In addition to vitamins, several other anti-oxidant substances are being screended for anti-aging effects, and some of these are found to have beneficial effects on the immune system (510,511).…”

Section: Vitamins and Minerals; Anti-oxidantsmentioning

confidence: 99%

T cells and aging (update February 1999)

Pawelec

1999

Front Biosci

113

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T cell immunosenescence 218effects of dysregulated immune responses in the elderly by supplementation or other approaches may result in an enhancement of their quality of life, and significant reductions in the cost of medical care in old age. FACTORS CONTRIBUTING TO IMMUNO-SENESCENCE HematopoiesisDysregulated hematopoiesis is seen in elderly individuals, raising the possibility that this could contribute to altered immune function in the aged. Hematopoiesis in man may be compromised because of a severely reduced capacity to produce colony stimulating factors (44) and increased production of pro-inflammatory factors such as IL 6 (45), because lower numbers of progenitor cells are present in the BM (46) and because of an age-related decline in proliferative potential of putative haematopoietic stem cells (HSC) (47). In mice, the repopulating potential of murine fetal liver-derived HSC is higher than that of adult BM-derived stem cells (48), suggesting possible aging of the HSC themselves. Normal cells with shorter telomeres possess less remaining replicative capacity than those with longer telomeres (see section 5.2). Accordingly, HSC from adult BM were found to have shorter telomeres than fetal liver-derived or umbilical cord-derived stem cells, consistent with aging of HSC (49). Telomere lengths decreased on culture despite low level expression of telomerase in these cells (50,51), although the rate of basepair loss per population doubling of cells in culture was lower during the first two weeks, when telomerase was upregulated, than in the next two, when it was downregulated (52). The telomerase expressed is therefore functionally active but may not be able to completely maintain telomere length in aging HSC cells. True embryonic stem cells (ESC), on the other hand, which may really be immortal, do retain high levels of telomerase activity (53). On the other hand, ESC from telomerase-knockout mice show gradual telomere shortening over many population doublings (PD) resulting in slowing and eventual cessation of growth (54). Certain animals which do not downregulate telomerase manifest a permanent growth phase and little or no senescence (55,56).

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Section: Vitamins and Minerals; Anti-oxidantsmentioning

confidence: 99%

T cells and aging (update February 1999)

Pawelec

1999

Front Biosci

113

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“…Lymphoproliferative responses to the T cell mitogen Conconavalin A (Con A) and the mobility of lymphocytes, both spontaneous and directed to a chemoattractant gradient (chemotaxis), as well as antibody-dependent cellular cytotoxicity (ADCC) and NK activity of leukocytes, were measured. While there was a significant decrease in function in all assays in aged versus young mice, the ingestion of thioproline augmented all the functions studied in aged animals [59]. In a similar type of study, mucosal immune responses in mice orally immunized with Haemophilus influenzae type b oligosaccharide conjugated to Diphtheria CRM197 protein (Hib-DT) vaccine using cholera toxin as a mucosal adjuvant were measured in aged versus control mice.…”

Section: Consistent Evidence For Altered Redox States In the Elderlymentioning

confidence: 95%

Aging and the immune system

Gorczynski

Terzıoğlu

2008

Int Urol Nephrol

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Aging is associated with many physiological changes in a variety of organ systems. Nevertheless, considerable interest has centred on the possibility that age-related immunological changes may play a key "master" role in regulating many, if not all, subsequent events. A growing body of data, some of it highlighted in this review, supports the notion that host resistance in general is changed in both a qualitative and quantitative manner with age, though the biochemical mechanism(s) underlying such changes are not unique to the immune system per se. Moreover, interventions designed to explore treatments which may reverse some or all of those age-related changes have pointed out a fundamentally important role for nutrition, and the way(s) in which this impacts on host resistance mechanism(s), as having a hitherto unappreciated importance in immunosenescence in general.

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“…A cepa Y de Trypanosoma cruzi possui picos parasitêmicos precoces, sendo altamente virulenta e patogênica, e produzindo uma alta mortalidade e lesões tissulares graves (Scorza e Scorza, 1972 (De La Fuente et al, 1998;Ferrandez et al, 1999). Além disso, animais tratados com T4C mostraram uma diminuição nos níveis de corticosterona (hormônio imunossupressor que diminui a resposta inflamatória) no soro (De La Fuente et al, 1998;Ferrandez et al, 1999) (Masoro, 2007).…”

Section: Discussionunclassified

“…Além disso, animais tratados com T4C mostraram uma diminuição nos níveis de corticosterona (hormônio imunossupressor que diminui a resposta inflamatória) no soro (De La Fuente et al, 1998;Ferrandez et al, 1999) (Masoro, 2007). Em um estudo, foi demonstrado que o ácido tânico, um polifenol de planta com atividades antioxidantes, anticarcinogênico e antimutagênico, prolonga a sobrevida de Caernorhabditis elegans e, além disso, melhora a resistência ao estresse por temperatura e aumenta, sutilmente, a resistência ao estresse oxidativo.…”

Section: Discussionunclassified

“…T4C também demonstrou efeito sobre o sistema imune de camundongos senescentes. A droga estimulou a resposta linfoproliferativa à Concanavalina A, a mobilidade dos linfócitos, quimotaxia, bem como, a atividade de leucócitos como exemplo, as células NK (De La Fuente et al, 1998). Além disso, os níveis de corticosterona, um hormônio imunussupressor, foram reduzidos no soro desses animais.…”

Section: Discussionunclassified

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Avaliação das perspectivas terapêuticas do ácido L-tiazolidina-4-carboxílico, um análogo de prolina, na infecção de camundongos pelo Trypanosoma cruzi.

Rocha¹

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Enhancement of leukocyte functions in aged mice supplemented with the antioxidant thioproline

Cited by 43 publications

References 27 publications

T cells and aging (update February 1999)

T cells and aging (update February 1999)

Aging and the immune system

Avaliação das perspectivas terapêuticas do ácido L-tiazolidina-4-carboxílico, um análogo de prolina, na infecção de camundongos pelo Trypanosoma cruzi.

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