Enhancement of Lysosomal Enzymes by the Pyrethroids, Fenvalerate and trans-Cypermethrin.

Balbaa, Mahmoud; Abdelhamid, Essam M.E.; Bassiouny, Khaled

doi:10.1248/jhs1956.44.83

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…Accordingly, there is a possibility that the processing of some lysosomal hydrolases in schistosomiasis, such as ASB, may be affected with respect to the recognition marker of these enzymes. Additionally, in another study [35], ASA, ASB and ␤-D-glucuronidase were enhanced in vivo as well as in vitro by pyrethroids. The in vivo enhancement was thought to be a result of modification of these enzymes.…”

Section: Discussionmentioning

confidence: 87%

Some hydrolases in human schistosomiasis with special reference to arylsulfatase B

Balbaa

Abbas

El-Deen

et al. 2003

International Journal of Environmental Studies

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Among many tested enzymes, lipase was found to be the one most affected by schistosomiasis in human serum, where it is increased eightfold. Arylsulfatases A and B and aspartyl protease displayed a significant decrease in the serum, while other enzymes showed a significant increase. ␣-Amylase and Leucine aminopeptidase were significantly increased and arylsulfatase B showed a significant decrease. Arylsulfatase B from a patient's leucocytes did not show either changed kinetic behaviour or temperature-dependent conformational changes. These results indicate that the diminished activity of this enzyme may be attributed to an opposing mechanism of regulation.

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Section: Discussionmentioning

confidence: 87%

Some hydrolases in human schistosomiasis with special reference to arylsulfatase B

Balbaa

Abbas

El-Deen

et al. 2003

International Journal of Environmental Studies

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“…Effect of quinazolinone derivatives on the activity of ATCase. In vivo effect of compounds 1, 2, 3 and 4 on ATCase was studied as described previously for other enzymes [43]. Briefly, mice were allocated randomly into six groups and each group contained five mice.…”

Section: Enzyme Assaymentioning

confidence: 99%

Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives

Balbaa

Abdel‐Megeed

Diab

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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Quinazolinone derivatives have been studied as both in vitro and in vivo inhibitors of aspartate transcarbamylase (ATCase). In vitro treatment of mammalian ATCase with four compounds revealed that they inhibited enzyme activity and that 2-phenyl-1,3-4(H)benzothiazin-4-thione was the most potent one. This compound acts as a noncompetitive inhibitor towards both aspartate and carbamoyl phosphate. The values of the inhibition constant (K i) indicate that this compound exerts a potent inhibitory effect upon ATCase activity. Moreover, in vivo treatment with different doses of these derivatives showed also an inhibitory effect upon ATCase, the relative activity being decreased by 40%-58% with a 1 mg dose. These data support the inhibition of ATCase by quinazolinone derivatives as a new type of inhibitor for the enzyme.

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“…Fenvalerate was shown to enhance altered hepatic foci and inhibit intercellular communication in vitro (Hemming et al, 1993). Recently, fenvalerate was shown to enhance the activity of hepatic lysosomal enzymes, and may act as a tumor promoter (Balbaa et al, 1998).…”

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Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats

Morisseau

Derbel

Lane

et al. 1999

Toxicological Sciences

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Racemic fenvaleric acid [2-(4-chlorophenyl)-3-methyl-butanoic acid], the principal metabolite of fenvalerate, was administrated orally at 0.75, 1.5, and 3.0 mmol/kg body weight/day to Fisher-344 male rats for 7 days. Both pure enantiomers of fenvaleric acid were administered at 1.5 mmol/kg body weight/day; the clofibric acid at the same concentration was used as a positive control. Hepatic enzyme activities were measured. Results obtained clearly show that fenvaleric acid induced numerous hepatic drug metabolism enzymes in F344 rats. The (R) enantiomer of this compound induces a proliferation of peroxisomes, whereas the (S) enantiomer induces CYP2B and mEH activities. Therefore, high exposure to pyrethroid insecticides could interact with the normal metabolism of drugs or xenobiotics.

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Enhancement of Lysosomal Enzymes by the Pyrethroids, Fenvalerate and trans-Cypermethrin.

Cited by 7 publications

References 2 publications

Some hydrolases in human schistosomiasis with special reference to arylsulfatase B

Some hydrolases in human schistosomiasis with special reference to arylsulfatase B

Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives

Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats

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