Enhancement of microvessel in laser speckle image using gaussian kernel template

Zhang, Yameng; Zhao, Yuemei; Li, Weitao; Qian, Zhiyu; Xing, Liudong

doi:10.1142/s1793545819500068

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…The CBF was calculated in Eq. 4 with the above sliding window, and the detailed algorithm was followed by our previous study and introduced earlier [ 32 ]: where was a calibration parameter, the speckle correlation decay time which was inversely related to . was the exposure time of the CCD camera.…”

Section: Methodsmentioning

confidence: 99%

Dual-modal in vivo assessment for electrophysical and hemodynamic characteristics of cerebral edema induced by lipopolysaccharide

Zhang

Xie

et al. 2022

BioMed Eng OnLine

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The pathological features of cerebral edema are complicated. The intracranial pressure (ICP) is regarded as the most important indicator for monitoring cerebral edema. Recently, multi-parameter has been used to explore the types and pathogenesis of cerebral edema and design effective treatment strategies. This research focused on investigating the characteristic of the cerebral edema induced by lipopolysaccharide (LPS) in rats by using simultaneous electrophysical and hemodynamic parameters. The results showed that neurophysiologic parameters (firing rate (FR) and the power spectrum of local field potential (LFP power)) and hemodynamic parameters (relative concentration of oxygenated hemoglobin (ΔCHbO2), relative concentration of deoxyhemoglobin ΔCHbR) and relative cerebral blood flow (rCBF)) were linearly correlated, and the Pearson’s correlation coefficient was changed by pathological progression of cerebral edema induced by LPS. Furtherly, the treatment after two agents were observed successfully through these multi-parameters. Our findings revealed the relationship between neural activity and hemodynamic response during the progression of cerebral edema and provided a multi-parameter solution for cerebral edema functional monitoring and anti-edema drug efficacy evaluation.

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Section: Methodsmentioning

confidence: 99%

Dual-modal in vivo assessment for electrophysical and hemodynamic characteristics of cerebral edema induced by lipopolysaccharide

Zhang

Xie

et al. 2022

BioMed Eng OnLine

Self Cite

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show abstract

“…The CBF was calculated in Eq.5 with the above sliding window, and the detailed algorithm was followed by our previous study and introduced earlier 14 .…”

Section: Brain Blood Flow Observation Using Laser Speckle Contrast Imagingmentioning

confidence: 99%

Dual-modal Assessment for in Vivo Investigation of Neurovascular Characteristic of Cerebral Edema Induced by Lipopolysaccharide

Zhang

Xie

et al. 2021

Preprint

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The pathological features of cerebral edema are complicated, but usually only intracranial pressure (ICP) is regarded as the most important indicator for monitoring cerebral edema. The research focused on investigating the neurovascular characteristic of the lipopolysaccharide (LPS)-induced cerebral edema model in rats by using simultaneous electrophysical and hemodynamic recording. The results showed that neurophysiology (firing rate (FR), interval histogram index (ISI), and the power spectrum of local field potential (LFPs power)) and hemodynamic response (oxygenated hemoglobin (HbO2), deoxyhemoglobin (HbR) and relative cerebral blood flow (CBF)) were linearly related, and the Pearson’s correlation coefficient was determined by the BBB integrity after LPS injection. Furtherly, the improvement of treatment after two agents were observed successfully through these neurophysiological and hemodynamic parameters. The optical-electrical joint method provided a technical solution for cerebral edema functional monitoring and anti-edema drug efficacy evaluation. Our findings revealed the neurovascular and BBB impact of cerebral edema and improved the limitation of in vivo pathological diagnosis of cerebral edema.

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“…For example, Sony et al enhanced signal-tonoise ratio (SNR) by anisotropic diffusion filtering, and then improved the speckle imaging speed sensitivity and temporal resolution [7]. Zhang et al adopted the line detector to optimize Gaussian matching filter in advance [8]. However, uncorrected scale and/or direction kernel may be obtained derived from the poor SNR, which failed to improve the visualization of blood vessels.…”

Section: Introductionmentioning

confidence: 99%

Enhancing laser speckle contrast imaging based on adaptive scale and directional kernel during V-PDT

Ren

Chen

Cao

et al. 2023

Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023)

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Laser Speckle Contrast Imaging (LSCI) as the advantages of high speed, wide field of view, and ease of implementation has been widely used for imaging blood flow and vascular deformation during Vascular targeted Photodynamic Therapy (V-PDT). However, uncorrected direction and or scale kernel failed to improve the visualization of blood vessels derived from poor Signal Noise Ratio (SNR) of micro vessels during V-PDT. In this study, we extracted the adaptive scale and directional kernel using dual-wavelength reflection imaging to enhance laser speckle imaging. The in vivo data showed that the proposed method improved the 4%-29% performance of contrast-to-noise ratio (CNR) and provide a powerful monitoring tool for blood flow and vascular deformation during V-PDT.

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Enhancement of microvessel in laser speckle image using gaussian kernel template

Cited by 5 publications

References 25 publications

Dual-modal in vivo assessment for electrophysical and hemodynamic characteristics of cerebral edema induced by lipopolysaccharide

Dual-modal in vivo assessment for electrophysical and hemodynamic characteristics of cerebral edema induced by lipopolysaccharide

Dual-modal Assessment for in Vivo Investigation of Neurovascular Characteristic of Cerebral Edema Induced by Lipopolysaccharide

Enhancing laser speckle contrast imaging based on adaptive scale and directional kernel during V-PDT

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