Enhancement of neural stem cell survival, proliferation and differentiation by IGF-1 delivery in graphene oxide-incorporated PLGA electrospun nanofibrous mats

Qi, Zhiping; Guo, Wenlai; Zheng, Shuang; Fu, Chen; Ma, Yue; S, Pan; Liu, Qinyi; Yang, Xiaoyu

doi:10.1039/c8ra10103e

Cited by 40 publications

(24 citation statements)

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“…Insulin-like growth factor-1 (IGF-1) was selected during this research due to its ability to promote stem cell proliferation and differentiation to neurogenic [ 29 ], osteogenic [ 30 ], and chondrogenic [ 31 ]. Furthermore, IGF-1 can be used for the treatment of various tissues, including muscle, bone, cartilage, liver, lung, nerve, and etc.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Ozone Treatment on the Physicochemical Properties and Biocompatibility of Electrospun Poly(ε)caprolactone Scaffolds

et al. 2021

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Ozonation has been proved as a viable surface modification technique providing certain properties to the scaffolds that are essential in tissue engineering. However, the ozone (O3) treatment of PCL scaffolds in aqueous environments has not yet been presented. O3 treatment performed in aqueous environments is more effective compared with traditional, executed in ambient air treatment due to more abundant production of hydroxyl radicals (•OH) within the O3 reaction with water molecules. During interaction with •OH, the scaffold acquires functional groups which improve wettability properties and encapsulate growth factors. In this study, a poly(ε)caprolactone (PCL) scaffold was fabricated using solution electrospinning and was subsequently ozonated in a water reactor. The O3 treatment resulted in the expected occurrence of oxygen-containing functional groups, which improved scaffold wettability by almost 27% and enhanced cell proliferation for up to 14 days. The PCL scaffold was able to withhold 120 min of O3 treatment, maintaining fibrous morphology and mechanical properties.

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Section: Methodsmentioning

confidence: 99%

The Effect of Ozone Treatment on the Physicochemical Properties and Biocompatibility of Electrospun Poly(ε)caprolactone Scaffolds

et al. 2021

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“…Therefore, improving both mitochondrial function and impaired cellular response to insulin might be a key strategy in the treatment of energetic deficit in ND diseases. A nanosystem composed of IGF-1 immobilized on GO-incorporated PLGA electrospun nanofibres used to promote survival, proliferation, and differentiation of neural stem cells [257] might be useful for such purposes. Another alternative would be the use of insulin sensitizers such as Pioglitazone (PIO), which is a therapeutic option for managing type 2 diabetes mellitus [258].…”

Section: Restoring Production and Utilization Of Mitochondrial Energy In Niandnddsmentioning

confidence: 99%

Nanotechnology-Based Drug Delivery Strategies to Repair the Mitochondrial Function in Neuroinflammatory and Neurodegenerative Diseases

2021

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Mitochondria are vital organelles in eukaryotic cells that control diverse physiological processes related to energy production, calcium homeostasis, the generation of reactive oxygen species, and cell death. Several studies have demonstrated that structural and functional mitochondrial disturbances are involved in the development of different neuroinflammatory (NI) and neurodegenerative (ND) diseases (NI&NDDs) such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Remarkably, counteracting mitochondrial impairment by genetic or pharmacologic treatment ameliorates neurodegeneration and clinical disability in animal models of these diseases. Therefore, the development of nanosystems enabling the sustained and selective delivery of mitochondria-targeted drugs is a novel and effective strategy to tackle NI&NDDs. In this review, we outline the impact of mitochondrial dysfunction associated with unbalanced mitochondrial dynamics, altered mitophagy, oxidative stress, energy deficit, and proteinopathies in NI&NDDs. In addition, we review different strategies for selective mitochondria-specific ligand targeting and discuss novel nanomaterials, nanozymes, and drug-loaded nanosystems developed to repair mitochondrial function and their therapeutic benefits protecting against oxidative stress, restoring cell energy production, preventing cell death, inhibiting protein aggregates, and improving motor and cognitive disability in cellular and animal models of different NI&NDDs.

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“…Composite hydrogels based on graphene and polyurethane, [ 104 ] composite films based on graphene and PLGA, [ 105 ] graphene‐based electrodes, [ 106 ] graphene, and cellulose fibers, [ 107 ] 3D brain cortex‐mimetic graphene‐based scaffolds [ 108 ] and bioresorbable elastomeric scaffolds [ 109 ] are a few more examples of GBMs were the mechanical properties, [ 104 ] topography, [ 109 ] and external electrical stimulus [ 106 ] were used to control the NSCs’ behavior. A more comprehensive discussion on the effect of GBMs in NSCs’ behavior can be found in the works of Xia et al, [ 95 ] Akhavan, [ 110 ] and Zhang et al [ 111 ]…”

Section: Gbms In Neurodegenerative Diseasesmentioning

confidence: 99%

Graphene‐Based Nanotechnology in Neurodegenerative Disorders

Tapeinos

2021

Advanced NanoBiomed Research

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Graphene‐based materials (GBMs) demonstrate unique electrochemical, mechanical, thermal, and optical properties rendering them attractive candidates for numerous biomedical applications. Since graphene's discovery, GBMs have been at the forefront of biomedical research offering innovative solutions for numerous diseases, including neurodegenerative disorders (NDs). There are numerous reviews in which synthesis and functionalization methods of GBMs are discussed. However, this review focuses specifically on the recent research advances of GBMs for NDs, and more specifically, on sensing and therapeutic applications. After a short description of NDs’ main characteristics, significant attention is given to the functionalization strategies used to improve the biomedical properties of GBMs, and recent applications for Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. A description of the use of GBMs and neural stem cell technology and known toxicity issues, followed by several limitations that current GBMs need to overcome, completes this review.

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Enhancement of neural stem cell survival, proliferation and differentiation by IGF-1 delivery in graphene oxide-incorporated PLGA electrospun nanofibrous mats

Abstract: The mammalian central nervous system has a limited ability for self-repair under injury conditions.

Cited by 40 publications

References 50 publications

The Effect of Ozone Treatment on the Physicochemical Properties and Biocompatibility of Electrospun Poly(ε)caprolactone Scaffolds

The Effect of Ozone Treatment on the Physicochemical Properties and Biocompatibility of Electrospun Poly(ε)caprolactone Scaffolds

Nanotechnology-Based Drug Delivery Strategies to Repair the Mitochondrial Function in Neuroinflammatory and Neurodegenerative Diseases

Graphene‐Based Nanotechnology in Neurodegenerative Disorders

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