Enhancement of nickel elution by lipopolysaccharide-induced inflammation

Tanaka, Rina; Goi, Yoshiaki; Ishihara, Kenji; Ueda, Kyosuke; Narushima, Takayuki; Ohtsu, Hiroshi; Hiratsuka, Masahiro; Hirasawa, Noriyasu

doi:10.1016/j.jdermsci.2010.12.006

Cited by 6 publications

(9 citation statements)

References 37 publications

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“…To enhance the elution of Ni ions from metals, 1 ‐ µl/ml lipopolysaccharide (LPS) injections were used to induce inflammation at the site after implantation. Control animals were pricked with the needle and injected with LPS.…”

Section: Methodsmentioning

confidence: 99%

Quantitative in vivo biocompatibility of new ultralow‐nickel cobalt–chromium–molybdenum alloys

Sonofuchi

Hagiwara

Koizumi

et al. 2016

Journal Orthopaedic Research

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Nickel (Ni) eluted from metallic biomaterials is widely accepted as a major cause of allergies and inflammation. To improve the safety of cobalt-chromium-molybdenum (Co-Cr-Mo) alloy implants, new ultralow-Ni Co-Cr-Mo alloys with and without zirconium (Zr) have been developed, with Ni contents of less than 0.01%. In the present study, we investigated the biocompatibility of these new alloys in vivo by subcutaneously implanting pure Ni, conventional Co-Cr-Mo, ultralow-Ni Co-Cr-Mo, and ultralow-Ni Co-Cr-Mo with Zr wires into the dorsal sides of mice. After 3 and 7 days, tissues around the wire were excised, and inflammation; the expression of IL-1β, IL-6, and TNF-α; and Ni, Co, Cr, and Mo ion release were analyzed using histological analyses, qRT-PCR, and inductively coupled plasma mass spectrometry (ICP-MS), respectively. Significantly larger amounts of Ni eluted from pure Ni wires than from the other wires, and the degree of inflammation depended on the amount of eluted Ni. Although no significant differences in inflammatory reactions were identified among new alloys and conventional Co-Cr-Mo alloys in histological and qRT-PCR analyses, ICP-MS analysis revealed that Ni ion elution from ultralow-Ni Co-Cr-Mo alloys with and without Zr was significantly lower than from conventional Co-Cr-Mo alloys. Our study, suggests that the present ultralow-Ni Co-Cr-Mo alloys with and without Zr have greater safety and utility than conventional Co-Cr-Mo alloys. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1505-1513, 2016.

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Section: Methodsmentioning

confidence: 99%

Quantitative in vivo biocompatibility of new ultralow‐nickel cobalt–chromium–molybdenum alloys

Sonofuchi

Hagiwara

Koizumi

et al. 2016

Journal Orthopaedic Research

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“…Using this model, we showed that LPS‐induced acute inflammation enhanced Ni elution and that Ni‐induced inflammation itself further enhanced it . In particular, neutrophil infiltration in the acute phase was involved in the elution.…”

Section: Discussionmentioning

confidence: 89%

“…The implantation of the Ni wire itself induced acute inflammation, which also enhanced Ni elution . These findings suggested that Ni elution from the wire was enhanced by leucocyte infiltration …”

Section: Introductionmentioning

confidence: 91%

“…Therefore, to analyse the regulation of Ni elution and Ni ion‐induced inflammation, we had established a Ni wire implantation model in mice. In this model, we found that Ni elution was enhanced by lipopolysaccharide (LPS)‐induced inflammation . The implantation of the Ni wire itself induced acute inflammation, which also enhanced Ni elution .…”

Section: Introductionmentioning

confidence: 92%

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Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration

Kishimoto

Asakawa

Sato

et al. 2017

Experimental Dermatology

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Histamine regulates various inflammatory reactions. We have reported that the expression of histidine decarboxylase (HDC) was induced by subcutaneous implantation of nickel (Ni) wire. However, the source and functions of histamine in Ni elution and Ni wire-induced inflammation have not been completely studied. We aimed to elucidate the effects of de novo synthesized histamine on leucocyte infiltration and Ni elution. Implantation of Ni wire induced an increase in the Ni ion content of the surrounding tissues and serum and in the mRNA levels of HDC, a histamine-producing enzyme, macrophage inflammatory protein-2 (MIP-2), a chemoattractant for neutrophils, and monocyte chemoattractant protein-1 (MCP-1), a chemoattractant for monocytes. The Ni wire induced HDC expression even in mast cell-deficient WBB6F1-W/W mice. In HDC knockout (HDC KO) mice, the Ni wire-induced increase in MIP-2 mRNA expression was significantly higher than that in wild-type mice but not MCP-1. MIP-2 expression was enhanced in histamine H2 receptor knockout (H2R KO) mice but not in WBB6F1-W/W mice. Histamine inhibited NiCl -induced MIP-2 mRNA expression in mouse bone marrow-derived macrophages (BMDMs) obtained from wild-type mice; this inhibition was not observed in BMDMs from H2R KO mice. Ni elution increased in HDC KO mice, in which leucocyte infiltration also increased, and was suppressed in mice treated with neutrophil-specific antibody. These results suggest that the Ni wire induced HDC expression in non-mast cells and that, in the chronic phase of inflammation, endogenous histamine reduced Ni elution, probably through regulation of MIP-2 expression and neutrophil migration.

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“…Furthermore, there is evidence that the amount of Ni(II) released by dental casting alloys is far below the daily Ni diet intake ranging between 150 and 600 pg [15,42,43]. Nevertheless, previously published studies demonstrated that changes in pH, LPS and mechanical stress may enhance the amount of metal release which might induce higher cytotoxic Ni(II) levels [4][5][6]8,44]. Surprisingly, we detected a slightly higher proliferation rate after 48 h when combining both stimuli (Ni(II) and IL-1␤) which was statistically significant (p < 0.01).…”

Section: Discussionmentioning

confidence: 99%