Pranic agriculture (PA) is a traditional healing technique. It includes the projection of prana onto the soil, seeds, water and seedlings to improve their growth. Lettuce plants were grown hydroponically and exposed to pranic energy. The study aimed to investigate the effects of PA treatment on the growth of lettuce plants grown hydroponically. Lettuce plants were grown in two different hydroponic sets. For both treatments, seeds, nutrient solutions, lighting, and all other conditions were the same. One set received PA treatment, while the other set, which did not receive any treatment, was referred to as control. Lettuce grown with pranic energy performed significantly better (p 0.05) in terms of vegetative growth [number of leaves (11.51.2), leaf length (16.80.9 cm), leaf area (1501293 cm2), and root length (14.92.4 cm)] when compared to control, having values of 9.51, 14.31.4 cm, 1004387 cm2, and 11.81.4 cm, respectively. Pranic energy influences hydroponically-grown lettuce plants. Pranic energy can be employed to promote plant growth and output. Farmers can use PA treatment to boost crop yields. The precise process through which Pranic energy influences plant development requires additional research.