The influence of variable operational conditions affects the performance of particle collection and separation of a regenerative air vacuum sweeper. Therefore, the purpose of this paper was to numerically investigate the factors affecting the particle suction efficiency of the pick-up head. Using computational fluid dynamics (CFD), a model of an integrated pick-up head was developed based on the particle suction process to evaluate the particle removal performance. The realizable k-ε and discrete particle models were utilized to study the gas flow field and solid particle trajectories. The particle structure, sweeping speed, secondary airflow, pressure drop, and distance between the particle suction port and the road surface, as factors that affect the particle removal efficiency, were investigated. The results indicate that the particle suction efficiency increases with decreasing sweeper speed. Furthermore, the particle overall removal efficiency increased with a reduction in the distance between the suction port and the road surface as well as the control of the secondary airflow in the system. By increasing the airflow rate at the suction port, high efficiencies were achieved at a high sweeper speed and high particle densities. At a sweeper speed of 6–10 km/h, the results showed that the secondary airflow recirculation varied between 60 to 80 %, while the high-pressure drop ranged from 2200 to 2400 Pa, and the particle suction efficiency recorded was 95%. The numerical analysis results provide a better understanding of the particle suction process and hence could lead to an improvement in the design of the pick-up head.