Enhancement of phagocytic activity of human monocytic-macrophagic cells by immunostimulating peptides from human casein

Gattegno, Liliane; Migliore‐Samour, Danièle; Saffar, Line; Jollès, Pierre

doi:10.1016/0165-2478(88)90065-x

Cited by 52 publications

(20 citation statements)

References 8 publications

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“…This peptide also stimulates, in a dose-dependant manner, the binding of human senescent RBC to human monocytic-macrophage cells and phagocytosis by these cells (Gattegno, Migliore-Samour, Saffar, & Jolles, 1988). This activity is correlated with the presence of specific binding sites on human blood phagocytic cells (Jaziri et al, 1992).…”

Section: Macrophage Functionmentioning

confidence: 89%

Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins

Gauthier

Pouliot

Saint-Sauveur

2006

International Dairy Journal

239

121

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Section: Macrophage Functionmentioning

confidence: 89%

Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins

Gauthier

Pouliot

Saint-Sauveur

2006

International Dairy Journal

239

121

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“…Moreover, immunomodulatory peptides might reduce allergic reactions in atopic humans, enhance mucosal immunity in the gastrointestinal tract and could have antitumour effects (Korhonen & Pihlanto, 2003). Immunomodulating peptides have been detected in cow as well as in human milk proteins (Gattegno, Migliore-Samour, Saffar & Jolles, 1988;Migliore-Samour & Jolles, 1988). Two peptides (β-casein, f54-f59 and α-lactalbumin, f51-f53) isolated from human milk protein digests were shown to enhance the phagocytic activity of macrophages in mice and humans, in addition to exerting resistance against certain bacteria in mice (Pérez-Castrillón et al, 2003).…”

Section: Immunomodulatory Peptidesmentioning

confidence: 99%

Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides

Girgih

Malomo

et al. 2014

Journal of Functional Foods

243

142

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The aim of this work was to produce enzymatic hemp seed protein hydrolysates (HPH) followed by bioassay guided fractionation to identify antioxidant and antihypertensive peptides. Therefore, simulated gastrointestinal digestion of isolated hemp seed proteins was conducted using consecutive actions of pepsin and pancreatin to produce HPH, which was then separated by membrane ultrafiltration to obtain peptide sizes of <1, 1-3, 3-5, and 5-10 kDa. Evaluation of HPH and its membrane fractions for antioxidant and antihypertensive properties showed that they significantly (P<0.05) scavenged radicals, reduced and strongly chelated metal ions as well as inhibited lipid oxidation. During a 24-hr test, the HPH reduced systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR) after oral administration by a maximum of -30 mmHg when compared to -15 mmHg for the membrane fractions.To reduce production cost, hemp seed protein meal (HPM) was directly hydrolyzed to a protein hydrolysate (HMH) and was shown to also reduce SBP during 4-8 weeks of dietary feeding. The attenuation of SBP correlated to suppressed plasma levels (0.047-0.059 U/mL and 0.040-0.054 µg/mL) of angiotensin converting enzyme (ACE) and renin, respectively, when compared to the control rats (0.123 U/mL and 0.151 µg/mL). A total of 23 peptides were identified to be present in the HPH. WVYY and PSLPA showed superior in vitro antioxidant properties, while ACE activity was inhibited by WYT (89%), WVYY (91%) and PSLPA (90%). Renin activity was inhibited by WYT (77%), SVYT (87%) and IPAGV (75%). However, oral administration to SHR showed that the pentapeptides (PSLPA and IPAGV) were more effective SBP-reducing agents (-40 mm Hg) when compared to the tri-(-13 mmHg) and tetrapeptides (-36 mmHg). These results

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“…Whey proteins such as b-lactoglobulin, a-lactalbumin, bovine serum albumin and lactoferrin have shown many effects on inflammatory cells [12]. In immunocompetent individuals, a stimulation of innate immunity is demonstrated by amplified phagocytosis activities [13][14][15][16][17], pro-inflammatory cytokine production [15,16,18], oxidative burst [13,19] and in increased adherence of cells to the epithelia [13]. The same proteins also have anti-inflammatory potential in inflammatory diseases, including a reduction of pro-inflammatory cytokines in inflammatory models [18,[20][21][22][23] and additional markers of inflammation such as ear thickness in a dermatitis model [22,24,25] as well as increasing regulatory cytokines [21].…”

Section: Introductionmentioning

confidence: 99%