Enhancement of Phagocytosis and Bactericidal Activity of Neutrophils in Miniature Pigs by Dihydroheptaprenol, a Synthetic Polyprenol Derivative

Araki, Seiichi; Suzuki, Mamoru; Ogura, Kazuaki; Kimura, Makoto; Imamura, Eisei; Kuniyasu, C; Kagaya, Keiko; Yoshimura, Fuminobu

doi:10.1111/j.1348-0421.1989.tb00974.x

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…In comparison with results previously obtained using an Escherichia coli infection (Araki et al, 1987), a reliable prophylactic effect was achieved in the present study using i.m. administration of the lecithin micro-emulsion variant of polyprenol designated preparation N2.…”

Section: Discussionsupporting

confidence: 61%

“…In our experiments, on the study of the prophylactic effect of Abies sibirica polyprenols, the administration scheme and the preparations doses were selected that showed the best results in the application of a lecithin emulsion of dolichol (dihydroheptaprenol) used in a colibacterial infection in mice (Araki et al, 1987). In comparison with results previously obtained using an Escherichia coli infection (Araki et al, 1987), a reliable prophylactic effect was achieved in the present study using i.m.…”

Section: Discussionmentioning

confidence: 48%

“…In experiments with synthetic 2,3-dihydroheptaprenol, a prophylactic effect was achieved against a generalized colibacterial infection in mice (Araki et al, 1987), and increased resistance to Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa was observed in animals treated with this compound. This effect appeared to be caused by non-specific activation of the cells of the reticuloendothelial system.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Intramuscularly Injected Polyprenols on Influenza Virus Infection in Mice

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et al. 2000

Antivir Chem Chemother

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This study demonstrates the possibility of achieving a prophylactic effect by intramuscular injection of Abies sibirica polyprenols for the control of influenza virus infection in mice. One of the five polyprenol preparations tested, preparation N1, which had the lowest hydrophilic-lipophilic balance (8.6), produced a significant protective effect when injected in a dose of 2000 μg/mouse 2 days before aerosol infection of mice with influenza virus. A moderate protective effect was also observed using a second preparation, designated N2. One day after aerosol infection, animals pre-treated with 2000 μg doses of the polyprenol preparations or Hanks' solution showed no difference in the level of interferon accumulation in the lungs. Three days after injection of preparation N2 and N1, a significant decrease in spleen and thymus weights was observed in the mice. One day after injection of these preparations, the number of lymphocytes in the bronchoalveolar tract of the mice exceeded almost twice that seen in mice treated with placebo. After 3 days, relative and absolute numbers of macrophages decreased, whereas those of lymphocytes increased significantly. Three days after the administration of preparations N1 and N2, macrophages became approximately twice as active in absorbing zymozan granules. Preparation N1 affected the system of superoxide radical anion production to a greater extent than preparation N2. The production of radical anions by the macrophages of the bronchoalveolar tract in the mice, 1 day after intramuscular injection of preparation N1, was significantly higher than that seen on day 3 and that induced by preparation N2 1 and 3 days after injection. These data indicate that emulsions of polyprenols that have relatively low hydrophilic-lipophilic balance, inhibit influenza virus infection in mice through a modulation of the host immune response.