2019
DOI: 10.1021/acsbiomaterials.8b01564
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Enhancement of Schwann Cells Function Using Graphene-Oxide-Modified Nanofiber Scaffolds for Peripheral Nerve Regeneration

Abstract: Peripheral nerve regeneration and functional recovery remain a significant clinical challenge. Biomaterials that can regulate biological behavior of Schwann cell (SC) and promote neural cell differentiation are beneficial for nerve regeneration and functional recovery. Graphene oxide (GO), as a bioactive nanomaterial, has attracted great attention in biomedical applications. In this study, the possibility of combining the excellent physicochemical properties of GO with nanofiber to develop a bioactive scaffold… Show more

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Cited by 60 publications
(59 citation statements)
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“…Despite the considerable success of artificial nerve implants for improving peripheral nerve regeneration [33,34], this treatment is still beset by limitations including the lack of effective induction cues for axon growth and Schwann cell migration and poor nutrient supply due to insufficient neovascularization, ultimately resulting in incomplete functional recovery. These drawbacks have inspired the development of numerous implantable scaffolds with physiochemical and/or biological premodifications designed to enhance bridging of the injured nerve [35]. To date, proteins and biomolecules such as fibronectin, IKVAV, and Tyr-Ile-Gly-Ser-Arg (YIGSR) have been incorporated into scaffolds to promote nerve cell adhesion and axon growth, and indeed these constructs have proven partially successful.…”
Section: Discussionmentioning
confidence: 99%
“…Despite the considerable success of artificial nerve implants for improving peripheral nerve regeneration [33,34], this treatment is still beset by limitations including the lack of effective induction cues for axon growth and Schwann cell migration and poor nutrient supply due to insufficient neovascularization, ultimately resulting in incomplete functional recovery. These drawbacks have inspired the development of numerous implantable scaffolds with physiochemical and/or biological premodifications designed to enhance bridging of the injured nerve [35]. To date, proteins and biomolecules such as fibronectin, IKVAV, and Tyr-Ile-Gly-Ser-Arg (YIGSR) have been incorporated into scaffolds to promote nerve cell adhesion and axon growth, and indeed these constructs have proven partially successful.…”
Section: Discussionmentioning
confidence: 99%
“…[ 5 ] However, the outcomes of regeneration were not better than several reports such as the heparin‐poloxamer thermosensitive hydrogel loaded with basic fibroblast growth factor and nerve growth factor (NGF), [ 47 ] and graphene‐oxide‐modified nanofiber scaffolds. [ 48 ] Our nerve conduits can be prepared in a very facile and gentle way without expensive machine such as electrospinning or 3D printing equipment. The loading of MeCbl is easily achieved without any consumption of the drug, and their amount can be achieved to a high value controlled by the feed ratio and the release can last for a relatively long time.…”
Section: Discussionmentioning
confidence: 99%
“…Researches indicated that electrical stimulation can guide axonal orientation, direct neurite extension and as a result, promote nerve regeneration 151,152 . Therefore, coating or mixing conductive compounds into scaffolds ameliorate the cellular activity, neural signal transferring, dendrite extensive branching, neurite outgrowth, neural proliferation, migration, and differentiation, leading to the functional recovery due to mimicking of the conductive nature of neurons 43,151,153‐159 . Electrically conductive compounds are divided into two types: carbon‐based (e.g., carbon nanotubes, graphene) and polymer‐based (e.g., polypyrrole (PPy), polyaniline (PANi), poly(3,4‐ethylenedioxythiophene) (PEDOT)) 160‐164 .…”
Section: Surface Modification Techniquesmentioning
confidence: 99%