Enhancement of Skin Immune Activities of Curcuma longa L. Leaf Extract by Ultra High Pressure Process

Kim, Nam Young; Lee, Hyeon Yong

doi:10.7783/kjmcs.2014.22.5.378

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Studies of CLLE are fewer than studies of roots and stems of curcuma; studies on medical applications of CLLE have been reported. Kim et al reported that CLLE enhances skin immunity [17]. Lee et al reported a novel extraction method for CLLE with low loss of active material [18].…”

Section: Introductionmentioning

confidence: 99%

Testing the Effectiveness of Curcuma longa Leaf Extract on a Skin Equivalent Using a Pumpless Skin-on-a-Chip Model

Kim

Jeon

Choi

et al. 2020

IJMS

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The in vitro tests in current research employ simple culture methods that fail to mimic the real human tissue. In this study, we report drug testing with a ‘pumpless skin-on-a-chip’ that mimics the structural and functional responses of human skin. This model is a skin equivalent constituting two layers of the skin, dermis and epidermis, developed using human primary fibroblasts and keratinocytes. Using the gravity flow device system, the medium was rotated at an angle of 15 degrees on both sides so as to circulate through the pumpless skin-on-a-chip microfluidic channel. This pumpless skin-on-a-chip is composed of upper and lower chips, and is manufactured using porous membranes so that medium can be diffused and supplied to the skin equivalent. Drug testing was performed using Curcuma longa leaf extract (CLLE), a natural product cosmetic ingredient, to evaluate the usefulness of the chip and the efficacy of the cosmetic ingredient. It was found that the skin barrier function of the skin epidermis layer is enhanced to exhibit antiaging effects. This result indicates that the pumpless skin-on-a-chip model can be potentially used not only in the cosmetics and pharmaceutical industries but also in clinical applications as an alternative to animal studies.

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Section: Introductionmentioning

confidence: 99%

Testing the Effectiveness of Curcuma longa Leaf Extract on a Skin Equivalent Using a Pumpless Skin-on-a-Chip Model

Kim

Jeon

Choi

et al. 2020

IJMS

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Analysis and Prediction of Cosmetic Properties in Creeping Rosemary

Kim,

Cho,

Cho

2024

JKFN

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In this study, antioxidant, whitening, anti-wrinkle, and pore contraction properties were analyzed. The total phenolic contents of creeping rosemary (CR) under optimal extraction conditions in water extract (CRWE) and 70% ethanol extract (CREE) were 23.03 mg/g and 29.56 mg/g, respectively. DPPH and ABTS free radical scavenging activities of CRWE and CREE were approximately 83% and 99% at 100 μg/g, respectively. Moreover, the antioxidant protection factor of CRWE and CREE was 1.83 and 1.84 at 100 μg/g, respectively. CRWE was shown 100% hyaluronidase inhibition, 45.38% collagenase inhibition as anti-inflammation and wrinkle improvement properties. CREE exerted higher inhibitory activities about tyrosinase, collagenase, elastase, hyaluronidase, astringent effect on 38.86%, 29.59%, 38.87%, 59.59%, and 14.14%, respectively. Using the support vector regression statistics model to predict optimal conditions for biological activity, the optimal inhibitory concentrations for DPPH, ABTS, and antioxidant protection factor were predicted to be 100 μg and TBARs was predicted to be 70 μg. The optimal inhibitory concentrations of tyrosinase and elastase were predicted to be 400 μg and 200 μg, respectively. For collagenase and hyaluronidase inhibition, the optimal concentrations were predicted to be 320 μg and 200 μg for CRWE and 400 μg of both enzymes for CREE, respectively. In addition, the optimal concentration for the astringent effect was predicted to be 400 μg. These results indicated the antioxidant, whitening, pore-tightening, and anti-wrinkle properties of CR extracts, which have potential use as ingredients for cosmetics.

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Enhancement of Skin Immune Activities of Curcuma longa L. Leaf Extract by Ultra High Pressure Process

Cited by 2 publications

References 13 publications

Testing the Effectiveness of Curcuma longa Leaf Extract on a Skin Equivalent Using a Pumpless Skin-on-a-Chip Model

Testing the Effectiveness of Curcuma longa Leaf Extract on a Skin Equivalent Using a Pumpless Skin-on-a-Chip Model

Analysis and Prediction of Cosmetic Properties in Creeping Rosemary

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