Enhancement of Skin Permeation of Glibenclamide from Ethyl Cellulose- Polyvinyl Pyrollidone based Transdermal Patches using Olive Oil and Mustard oil as Penetration Enhancer: In Vitro, Ex-Vivo and In Vivo Evaluation

Rastogi, Vaibhav; Pragya,; Kumar, Arvind; Porwal, Mayur; Mishra, Arun Kumar; Verma, Navneet Chandra; Verma, Anurag

doi:10.2174/2210303105666150728205154

Cited by 10 publications

(2 citation statements)

References 4 publications

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“…The release was more than 65% for all formulations except F6 and F7 where it was 60.2 and 64.2%, respectively. The increased drug release by formulation F2 may be a response attributed to high concentration of olive oil (Rastogi et al, 2015). The variability in the drug release behavior was studied by applying different kinetic models to develop an understanding about the structure of emulgel matrix.…”

Section: Determination Of Drug Contentmentioning

confidence: 99%

Untitled

2021

Pak. J. Pharm. Sci

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Development of dimenhydrinate (DMN) emulgel formulation has been described in this work with enhanced permeation for transdermal delivery of DMN for effective management of motion sickness. Various DMN emulgel formulations were prepared using central composite design in response surface methodology. Propylene glycol and olive oil were used in varying ratios as permeation enhancers along-with carbopol-934 as gelling agent. Prepared formulations were evaluated by physico-chemical properties, stability and Fourier transform infrared spectroscopy (FTIR) studies. Invitro drug release was studied using cellophane membrane. Formulation F2 showed maximum drug permeation following diffusion-based release mechanism and was used in further studies. Rat skin was used in Franz cell for ex-vivo studies to determine various permeation kinetic parameters. FTIR studies provided no evidence of chemical interaction between DMN and polymers used, whereas molecular docking revealed formation of a stable complex in the presence of aqueous environment with stable intermolecular binding and the complex was well hydrated. No evidence of skin irritation was observed in human volunteers following application of the optimized formulation. Histopathology data of the rat skin showed a decreased proliferation of the lymphocytes whereas monocytes were induced. In conclusion, combination of propylene glycol and olive oil was successfully employed for delivery of DMN through transdermal route with good permeability and prolonged release time that can be highly beneficial in treating motion sickness in unusual circumstances.

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Section: Determination Of Drug Contentmentioning

confidence: 99%

Untitled

2021

Pak. J. Pharm. Sci

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“…The values of the diffusional exponent (n) determined from in vitro metoprolol Succinate permeation from all these pressuresensitive adhesive-based transdermal patches ranged between 0.685 and 0.948 [ Table 9] following anamolous transport which refers to the controlled release of drug by the combination of both diffusion and erosion of the matrix. [16] Skin irritation studies…”

Section: Statistical Kineticsmentioning

confidence: 99%