Enhancement of solubility and bioavailability of modafinil using nanoparticles

Abstract

The aim of the present work is to develop polymeric nanoparticles using Modafinil to improve its solubility, thereby increasing its bioavailability. Ionic-Gelation method has been employed for the preparation of nanoparticles using chitosan, a natural polymer, and TPP, a cross-linking agent. In this method, the drug is mixed with a polymer and maintained at a pH between 4.5 - 5.5, and the solution of TPP is added to the polymer-drug mixture under magnetic stirring. The size of nanoparticles prepared by this method usually ranges from 1-1000 nm. The reduction in the size of particles directly enhances the solubility of drug that increases its bioavailability. Nine formulations (F1-F9) of nanoparticles were optimized by varying the concentrations of chitosan and TPP. Prepared nanoparticles were evaluated for size, zeta potential, PDI, and drug content. Formulation F9 with 0.25% of chitosan & 0.5% of TPP concentration has been chosen as best formulation and lyophilized to obtain solid nanoparticles. The obtained nanoparticles loaded with modafinil are used for the preparation of tablets, and the in-vitro dissolution characteristics are compared with the marketed tablet of modafinil. in-vitrocharacteristics of tablets with modafinil loaded polymeric nanoparticles showed improved solubility than a marketed tablet.