Enhancement of T suppressor activity in mice by high doses of BCG

Geffard, M.; Orbach-Arbouys, S.

doi:10.1007/bf00205292

Cited by 44 publications

(23 citation statements)

References 3 publications

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“…A high dose of BCG (1 mg), however, dramatically inhibited the emergence of an immune response. Such a negative effect has previously been shown by many authors (Davies & Sabbadini, 1977;Florentin et al, 1976;Turcotte et al, 1978;Geffard & Orbach-Arbouys, 1976;Watson & Collins, 1980;Klimpel, 1979) to the progressive development of BCG colonies in the spleen of the treated mice.…”

Section: Discussionmentioning

confidence: 63%

Suppressor T cells in BCG-treated mice interfere with an in vivo specific antitumoral immune response

Payelle¹,

Brulay-Rosset²,

Poupon³

et al. 1984

Br J Cancer

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Section: Discussionmentioning

confidence: 63%

Suppressor T cells in BCG-treated mice interfere with an in vivo specific antitumoral immune response

Payelle¹,

Brulay-Rosset²,

Poupon³

et al. 1984

Br J Cancer

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“…BCGstrain, dose, application route, and individual reactivity are critical for antitumor activity (Math6, 1976a and b). A too intensive BCG-septieemia seems to be immuno--suppressive and may promote tumor growth by stimulation of suppressor cells (Florentin et al, 1976;Geffard et al, 1976) or by induction of blocking factors. Measuring spontaneous cytotoxicity immediately after BCG may be one way to assess the optimal dose for effective stimulation of the individual patient.…”

Section: Discussionmentioning

confidence: 96%

Regional BCG-therapy of malignant melanoma: In vitro monitoring of spontaneous cytolytic activity of circulating lymphocytes

Saal

Riethmüller

Rieber

et al. 1977

Cancer Immunol Immunother

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“…C57BL/6 (H-2b) female mice, [6][7][8][9][10] weeks old, were obtained from Charles River Laboratories (Wilmington, MA). Mice treated with BCG (Tice strain, University of Illinois) were given 2 X 107 viable units intravenously.…”

Section: Methodsmentioning

confidence: 99%

Systemic bacillus Calmette-Guérin (BCG) activates natural suppressor cells.

Bennett¹,

Rao²,

Mitchell³

1978

Proc. Natl. Acad. Sci. U.S.A.

103

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Addition of normal C57BL/6 mouse bone marrow cells to an in vitro culture of normal C57BL/6 spleen cells and allogeneic P815-Y tumor cells inhibited the development of cell-mediated immunity. Bacillus Calmette-Guérin (BCG) enhanced the suppressive activity of these bone marrow cells as early as 2 days after its intravenous administration to donor mice and elicited similar activity in the spleen by 7 days. Concomitant with the appearance of suppressor cells in the spleen there was a decrease in bone cell number and an increase in spleen cell number. While normal spleen cells failed to inhibit immunization, spleen cells from thymectomized, irradiated, bone marrow-reconstituted mice were inhibitory. Administration of BCG further increased the suppressive activity of spleen cells in these T cell-deprived mice. From this evidence it appears that systemic administration of BCG activates natural suppressor cells in the bone marrow and elicits suppressor cells in the spleen through the migration and colonization of the spleen by bone marrow elements.

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Enhancement of T suppressor activity in mice by high doses of BCG

Cited by 44 publications

References 3 publications

Suppressor T cells in BCG-treated mice interfere with an in vivo specific antitumoral immune response

Suppressor T cells in BCG-treated mice interfere with an in vivo specific antitumoral immune response

Regional BCG-therapy of malignant melanoma: In vitro monitoring of spontaneous cytolytic activity of circulating lymphocytes

Systemic bacillus Calmette-Guérin (BCG) activates natural suppressor cells.

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