2021
DOI: 10.2147/ijn.s307648
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Enhancement of T2* Weighted MRI Imaging Sensitivity of U87MG Glioblastoma Cells Using γ-Ray Irradiated Low Molecular Weight Hyaluronic Acid-Conjugated Iron Nanoparticles

Abstract: Introduction It has been reported that low-molecular-weight hyaluronic acid (LMWHA) exhibits a potentially beneficial effect on cancer therapy through targeting of CD44 receptors on tumor cell surfaces. However, its applicability towards tumor detection is still unclear. In this regard, LMWHA-conjugated iron (Fe 3 O 4 ) nanoparticles (LMWHA-IONPs) were prepared in order to evaluate its application for enhancing the T2* weighted MRI imaging sens… Show more

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Cited by 3 publications
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“…In addition to the gel-forming properties, HA can also be applied in targeted drug delivery [ 19 ]. In our experiments, GA was applied due to having high potency to function as a proper cross-linker and because the nasal lining is fairly resistant to aldehyde toxicity below millimolar concentrations [ 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…In addition to the gel-forming properties, HA can also be applied in targeted drug delivery [ 19 ]. In our experiments, GA was applied due to having high potency to function as a proper cross-linker and because the nasal lining is fairly resistant to aldehyde toxicity below millimolar concentrations [ 20 ].…”
Section: Introductionmentioning
confidence: 99%