Enhancement of the Adhesive Properties by Optimizing the Water Content in PNIPAM-Functionalized Complex Coacervates

Dompè, Marco; Vahdati, Mehdi; Ligten, Froukje Van; Serrano, Francisco Javier Cedano; Hourdet, Dominique; Creton, Costantino; Zanetti, Marco; Bracco, Pierangiola; Gucht, Jasper van der; Kodger, Thomas E.; Kamperman, Marleen

doi:10.1021/acsapm.0c00185

Cited by 24 publications

(29 citation statements)

References 52 publications

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“…By removing water from the coacervates via extrusion at 50 ºC, Dompé et al managed to improve both the stiffness and the dissipative properties of the material and hence increase underwater adhesion by one order of magnitude. 34 Here we propose simple model coacervates based on two oppositely charged polyacrylamides with DPs in the range of 100, much lower than the focus of previous studies. 6,24,28,32,33,40 In particular, we benefit from such small DPs to tune the sol-gel transition around physiological salt concentrations, which can be exploited for the purpose of underwater adhesion.…”

Section: Introductionmentioning

confidence: 94%

“…Recently, our team extended the use of this setup to study the underwater adhesion of different hard substrates against thermoresponsive complex coacervates. 34,49 We used the procedure of Cedano-Serrano et. al 48 to study underwater adhesion between our thermoresponsive complex coacervates and crosslinked thin films of PAA covalently bound to silicon wafers.…”

Section: Underwater Probe Tackmentioning

confidence: 99%

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Coacervate-Based Underwater Adhesives in Physiological Conditions

Vahdati

Cedano‐Serrano

Creton

et al. 2020

ACS Appl. Polym. Mater.

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Soft underwater adhesives which can function in physiological environments are in high demandfor biomedical applications. This study establishes a clear link between the composition and mechanical properties of complex coacervates from poly(2-acrylamido-2-methylpropane sulfonic acid) (PAMPS) and poly (N,N-[(dimethylamino) propyl]methacrylamide) (PMADAP) with degrees of polymerization (DP) close to 100. Choosing such low DPs offers several advantages including low water contents corresponding to strong mechanical properties while remaining in the unentangled regime to allow injectability at high salt concentrations. Most importantly, this strategy favors the occurrence of the salt-induced sol-gel transition near physiological concentrations, where these materials form sticky hydrogels due to their viscoelastic dissipative nature. The fluid-like coacervate prepared at 0.75 M NaCl behaves as a soft adhesive when injected in physiological conditions. This adhesive satisfies a nontrivial tradeoff between injectability and final mechanical properties. Alternatively, the gel-like coacervate prepared at 0.1 M NaCl offers an instant-stick solution in physiological conditions with a remarkable underwater adhesion energy of 65 J.m -2 without the need to a trigger or any form of postreinforcement. These coacervates mimic the behavior of soft adhesives in air and may be useful as biomedical adhesives.

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Section: Introductionmentioning

confidence: 94%

Section: Underwater Probe Tackmentioning

confidence: 99%

Coacervate-Based Underwater Adhesives in Physiological Conditions

Vahdati

Cedano‐Serrano

Creton

et al. 2020

ACS Appl. Polym. Mater.

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“…Polyelectrolyte complexes (PECs) are electrostatically selfassembled soft materials that are finding increasing utility in diverse domains as underwater adhesives, [1][2][3][4][5][6] encapsulants and drug delivery agents, [7][8][9][10][11] membrane-less protocell models, 12,13 water purification agents, 14 membranes for separation processes, [15][16][17] and barrier films for packaging. 18,19 In many of these applications, PECs are exposed to monovalent (e.g., K + , Na + , Cl À ) and multivalent ions (e.g., Ca 2+ , SO 4 2À , Fe 3+ in biological systems, Mg 2+ in wastewater, PO 4 3À in buffers).…”

Section: Introductionmentioning

confidence: 99%

Influence of divalent ions on composition and viscoelasticity of polyelectrolyte complexes

Iyer

Syed

Srivastava

2021

Journal of Polymer Science

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The addition of monovalent salts to polyelectrolyte complexes (PECs) comprising oppositely charged polyelectrolytes results in diminishing propensity for complexation, leading to complexes with higher water contents and lower moduli. However, the corresponding influence of multivalent ions on polyelectrolyte complexation has not yet been explored beyond enhanced screening effects. Here, we elucidate the significant impact of the valency of the salt cation on the composition, ion partitioning, and viscoelasticity of charge‐matched PECs comprising sodium salt of poly(acrylic acid) and poly(allylamine hydrochloride). Notably, preferential partitioning of divalent cations (Ca2+ and Sr2+) into the complexes is observed, in stark contrast to the depletion of monovalent ions (Na+) from the complexes. Concomitantly, electrostatic bridging of polyanion chains by divalent ions is found to hinder their relaxation, manifesting as a non‐monotonic evolution of the shear moduli of the complexes with increasing divalent salt concentrations. Relatedly, a failure of time‐salt and time‐ionic strength superposition approaches in presence of divalent ions is demonstrated, highlighting the nontrivial influence of these ions on chain relaxation behavior.

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“…However, these methods can cause a deficiency of tissue integration, significant mismatch between tissue and fixation, leakage, and additional trauma leading to surgical site infection (SSI) by microorganisms [ 3 , 4 ]. Tissue glue as a physical barrier device against microorganism penetration can provide a fast and noninvasive option with easier application method compare to the traditional invasive techniques [ 5 ]. Tissue glues can be categorized mainly as fibrin-, cyanoacrylate-, or polyurethane-based glues regarding to their structure or as hemostats, sealants, and adhesives based on their intended use and application [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel In Vitro Method to Assess the Microbial Barrier Function of Tissue Adhesives Using Bioluminescence Imaging Technique

Mirzaei

Hagemeister²,

Hüffel

et al. 2022

BioMed Research International

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Background. Tissue glues can minimize treatment invasiveness, mitigate the risk of infection, and reduce surgery time; ergo, they have been developed and used in surgical procedures as wound closure devices beside sutures, staples, and metallic grafts. Regardless of their structure or function, tissue glues should show an acceptable microbial barrier function before being used in humans. This study proposes a novel in vitro method using Escherichia coli Lux and bioluminescence imaging technique to assess the microbial barrier function of tissue glues. Different volumes and concentrations of E. coli Lux were applied to precured or cured polyurethane-based tissue glue placed on agar plates. Plates were cultured for 1 h, 24 h, 48 h, and 72 h with bioluminescence signal measurement subsequently. Herein, protocol established a volume of 5 μL of a 1 : 100 dilution of E. coli Lux containing around 2 × 10 7 CFU/mL as optimal for testing polyurethane-based tissue glue. Measurement of OD600nm, determination of CFU/mL, and correlation with the bioluminescence measurement in p/s unit resulted in a good correlation between CFU/mL and p/s and demonstrated good reproducibility of our method. In addition, this in vitro method could show that the tested polyurethane-based tissue glue can provide a reasonable barrier against the microbial penetration and act as a bacterial barrier for up to 48 h with no penetration and up to 72 h with a low level of penetration through the material. Overall, we have established a novel, sensitive, and reproducible in vitro method using the bioluminescence imaging technique for testing the microbial barrier function of new tissue glues.

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Enhancement of the Adhesive Properties by Optimizing the Water Content in PNIPAM-Functionalized Complex Coacervates

Cited by 24 publications

References 52 publications

Coacervate-Based Underwater Adhesives in Physiological Conditions

Coacervate-Based Underwater Adhesives in Physiological Conditions

Influence of divalent ions on composition and viscoelasticity of polyelectrolyte complexes

A Novel In Vitro Method to Assess the Microbial Barrier Function of Tissue Adhesives Using Bioluminescence Imaging Technique

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